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Wiskott-Aldrich syndrome and cerebral neoplasia: Report of a case with localized reticulum cell sarcoma

  1. Kathleen P. Heidelberger MD†,*,
  2. Dennis P. Legolvan MD‡

Article first published online: 27 JUN 2006

DOI: 10.1002/1097-0142(197401)33:1<280::AID-CNCR2820330141>3.0.CO;2-H

Issue

Cancer

Cancer

Volume 33, Issue 1, pages 280–284, January 1974

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How to Cite

Heidelberger, K. P. and Legolvan, D. P. (1974), Wiskott-Aldrich syndrome and cerebral neoplasia: Report of a case with localized reticulum cell sarcoma. Cancer, 33: 280–284. doi: 10.1002/1097-0142(197401)33:1<280::AID-CNCR2820330141>3.0.CO;2-H

Author Information

  1. Department of Pathology, The University of Michigan, Ann Arbor, Michigan

  1. †

    Assistant Professor of Pathology.

  2. ‡

    Resident IV.

*Department of Pathology, The University of Michigan, Ann Arbor, Michigan 48104

Publication History

  1. Issue published online: 27 JUN 2006
  2. Article first published online: 27 JUN 2006
  3. Manuscript Received: 14 MAY 1973

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Abstract

A case of Wiskott-Aldrich Syndrome with survival to nineteen-years old is reported. The patient developed reticulum cell sarcoma primary in the brain, which was biopsied and treated with irradiation and chemotherapy. When the patient expired 4 1/2 months postoperatively, no tumor was present; death was the result of bronchopneumonia. Review of the literature revealed 14 prior cases of neoplasm in Wiskott-Aldrich Syndrome, 11 of them lymphoreticular. In only one other case was lymphoreticular neoplasm confined to the brain. In no other cases is there necropsy-documented absence of neoplasm. The incidence of neoplasia occurring with this syndrome in this review is approximately 10%, and is predominantly lymphoreticular. Current diagnostic and therapeutic measures may make such localized neoplasms amenable to cure.

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