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Of birds and mice and men: Comments on the use of animal models and molecular hybridization in the search for human tumor viruses

  1. J. M. Bishop MD Professor of Microbiology*,
  2. N. Quintrell MA,
  3. E. Medeiros MA,
  4. H. E. Varmus MD Assistant Professor of Microbiology

Article first published online: 28 JUN 2006

DOI: 10.1002/1097-0142(197410)34:8+<1421::AID-CNCR2820340813>3.0.CO;2-0

Issue

Cancer

Cancer

Supplement: Proceddings of the American Cancer Society-National Cancer Institute National Conference on Virology and Immunology in Human Cancer

Volume 34, Issue Supplement S4, pages 1421–1426, October 1974

Additional Information

How to Cite

Bishop, J. M., Quintrell, N., Medeiros, E. and Varmus, H. E. (1974), Of birds and mice and men: Comments on the use of animal models and molecular hybridization in the search for human tumor viruses. Cancer, 34: 1421–1426. doi: 10.1002/1097-0142(197410)34:8+<1421::AID-CNCR2820340813>3.0.CO;2-0

Author Information

  1. Department of Microbiology, University of California, San Francisco, CA

*Dept. of Microbiology, University of California, San Francisco, CA 94143

Publication History

  1. Issue published online: 28 JUN 2006
  2. Article first published online: 28 JUN 2006
  3. Manuscript Received: 25 JUN 1974

Funded by

  • USPHS. Grant Number: CA 12705
  • Virus Cancer Program of the National Cancer Institute. Grant Number: NO1 CP 33293
  • Research Career Development. Grant Number: CA 70193
  • National Cancer Institute

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Abstract

Infection of either duck or mammalian cells with Rous sarcoma virus introduces a new set of genes into the chromosomal DNA of the host cell. This event is a prerequisite for both replication of the virus and neoplastic transformation of the cells. By contrast, virus-induced mammary carcinoma in the mouse can be inherited disease without requirement for genetic information beyond that already present in the mouse genome. This communication illustrates certain molecular correlates of the preceding biological observations, and comments on the use of these correlates in designing and executing the search for RNA tumor viruses of man.

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