Chief Resident Surgical Pathology. Current position: Assistant Professor of Surgical Pathology, Medical College of Virginia, Richmond, VA.
Malignant soft tissue tumors of probable histiocytic origin (malignant fibrous histiocytomas): General considerations and electron microscopic and tissue culture studies
Article first published online: 27 JUN 2006
Copyright © 1975 American Cancer Society
Volume 35, Issue 1, pages 176–198, January 1975
How to Cite
Fu, Y.-S., Gabbiani, G., Kaye, G. I. and Lattes, R. (1975), Malignant soft tissue tumors of probable histiocytic origin (malignant fibrous histiocytomas): General considerations and electron microscopic and tissue culture studies. Cancer, 35: 176–198. doi: 10.1002/1097-0142(197501)35:1<176::AID-CNCR2820350123>3.0.CO;2-N
- Issue published online: 27 JUN 2006
- Article first published online: 27 JUN 2006
- Manuscript Received: 2 OCT 1974
- NIAMD, NIH, USPHS. Grant Number: AM-12396
- American Cancer Society. Grant Number: ET-15-F
- Fonds National Suisse de la Recherche Scientifique. Grant Number: 3.356.70
Correlated light and electron microscopic study of four fibrous histiocytomas of proven malignancy has confirmed the presence of histiocyte-like and fibroblast-like cells in this tumor. In addition, an undifferentiated cell type, giant cells, xanthomatous cells, and rare cells with morphological characteristics intermediate between those of histiocytes and fibroblasts were seen. “Nuclear body” type inclusions were commonly present in both principal cell types in all four cases, as were the somewhat less common cytoplasmic inclusion bodies. Electron microscopic study of a tissue culture of one of these tumors demonstrated only fibroblast-like, histiocyte-like, and xanthomatous cells. The possibility is suggested that both principal cell types in this tumor may derive from the same undifferentiated stem cell.