Fellow in Hematology and Fellow of the Leukemia Society of America, Inc.
Febrile neutrophilic dermatosis in acute myelogenous leukemia
Article first published online: 27 JUN 2006
Copyright © 1976 American Cancer Society
Volume 37, Issue 2, pages 922–927, February 1976
How to Cite
Klock, J. C. and Oken, R. L. (1976), Febrile neutrophilic dermatosis in acute myelogenous leukemia. Cancer, 37: 922–927. doi: 10.1002/1097-0142(197602)37:2<922::AID-CNCR2820370245>3.0.CO;2-P
- Issue published online: 27 JUN 2006
- Article first published online: 27 JUN 2006
- Manuscript Received: 13 DEC 1974
- U.S. Public Health Service, Bethesda, MD. Grant Number: AM-16095
Three patients with acute myelogenous leukemia and adequate granulocyte reserves developed fever and painful indurated erythematous plaques on their extremities and faces. The plaques became studded with vesicles or bullae and occasionally became necrotic. Histologic examination revealed dermal edema, infiltration with granulocytes, and formation of intraepidermal vesicles. Efforts to relate the skin reaction to infiltration of leukemic cells, microorganisms, or allergic phenomena were unsuccessful. Empiric antibiotic therapy was without effect. The symptoms and signs responded dramatically to systemic administration of corticosteroids. These lesions, which may cause diagnostic confusion and needless therapy with potent antibiotics, may represent another previously uncharacterized nonspecific skin reaction in patients with acute myelogenous leukemia.