Increased incidence of brain metastases in sarcoma patients

Authors

  • Pilar Espana MD,

    Corresponding author
    1. Baltimore Cancer Research Center, National Cancer Institute, Division of Cancer Treatment, Baltimore, Maryland 21201
    Current affiliation:
    1. Clinica Puerta de Hierro, San Martin de Porres, 4, Madrid—35, Spain
    • Medicina Interna I, Clínica Puerta de Hierro, San Martin de Porres, 4, Madrid—35, Spain
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  • Paul Chang MD,

    1. Baltimore Cancer Research Center, National Cancer Institute, Division of Cancer Treatment, Baltimore, Maryland 21201
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  • Peter H. Wiernik MD

    1. Baltimore Cancer Research Center, National Cancer Institute, Division of Cancer Treatment, Baltimore, Maryland 21201
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Abstract

Eleven cases of brain metastases that developed in 114 sarcoma patients are presented. Two of 11 patients presented with brain metastasis at the time of diagnosis and the other nine developed them later. The high incidence of brain metastases in patients with rhabdomyosarcoma (26%) and malignant fibrous histiocytoma (27%), two types of tumor which supposedly metastasize rarely to the brain, is remarkable. The increased incidence of brain metastases may be related to longer survival of sarcoma patients and to the inability of AMN and other drugs used in the treatment of sarcomas to cross the blood-brain barrier. Preventive treatment of brain metastases with drugs active in the CNS or with radiotherapy following the diagnosis of pulmonary metastases, could be useful, especially in patients with rhabdomyosarcoma and malignant fibrous histiocytoma.

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