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In vitro evidence for an unusual progenitor cell in acute monocytic leukemia

  1. Raymond Taetle MD Assistant Professor1,*,
  2. Linda Ivor BA, MT2,†

Article first published online: 28 JUN 2006

DOI: 10.1002/1097-0142(19801001)46:7<1602::AID-CNCR2820460719>3.0.CO;2-P

Issue

Cancer

Cancer

Volume 46, Issue 7, pages 1602–1607, 1 October 1980

Additional Information

How to Cite

Taetle, R. and Ivor, L. (1980), In vitro evidence for an unusual progenitor cell in acute monocytic leukemia. Cancer, 46: 1602–1607. doi: 10.1002/1097-0142(19801001)46:7<1602::AID-CNCR2820460719>3.0.CO;2-P

Author Information

  1. 1

    Division of Hematology/Oncology, Department of Medicine, University of California, San Diego

  2. 2

    Department of Pathology, San Diego Veterans Administration Hospital, San Diego, California

  1. †

    Chief, Special Hematology.

*Division of Hematology/Oncology (H811K), Department of Medicine, University of California, Medical Center, San Diego, 225 W. Dickinson St., San Diego, California 92103.

  1. †

    Chief, Special Hematology.

Publication History

  1. Issue published online: 28 JUN 2006
  2. Article first published online: 28 JUN 2006
  3. Manuscript Accepted: 31 OCT 1979

Funded by

  • Veterans Administration Research Council

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Abstract

The peripheral blood of 2 patients with acute monocytic leukemia of the undifferentiated type was studied for the presence of leukemic progenitor cells in colony forming assays. The peripheral blood of both patients contained only one type of progenitor cell as determined with these assay systems. Daughter cells of these progenitor cells morphologically and histochemically resembled monoblasts and immature macrophages. Similar progenitor cells were not encountered in the study of 5 patients with acute myelogenous leukemia whose peripheral blood cells formed colonies in the same system. The finding of this unusual progenitor cell supports the existence of acute monocytic leukemia as a separate clinicopathologic entity, and suggests that it represents a malignant transformation of a progenitor cell of the monocyte/macrophage series. An alternative explanation of these observations would be provided by single phenotypic expressions of a multi-potent stem cell which has undergone malignant transformation.

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