Bile duct adenocarcinoma with leser-trelat sign and pure red blood cell aplasia

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Abstract

A case of adenocarcinoma of the bile duct complicating longstanding ulcerative colitis and associated with the rapid onset and growth of multiple seborrheic keratosis (Leser-Trelat sign) and pure red blood cell aplasia is described. This is the first report of a case of the coexistence of the Leser-Trelat sign and pure red blood cell aplasia in a patient with a malignancy. Both manifestations have been doubted as truly paraneoplastic manifestations because of their rarity in clinical medicine. Their co-existence in the present case would support their association with malignancy.

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