Article
You have full text access to this OnlineOpen article
Glucose turnover, gluconeogenesis from glycerol, and estimation of net glucose cycling in cancer patients
Article first published online: 28 JUN 2006
DOI: 10.1002/1097-0142(19820915)50:6<1142::AID-CNCR2820500618>3.0.CO;2-I
Copyright © 1982 American Cancer Society
Additional Information
How to Cite
Lundholm, K., Edström, S., Karlberg, I., Ekman, L. and Scherstén, T. (1982), Glucose turnover, gluconeogenesis from glycerol, and estimation of net glucose cycling in cancer patients. Cancer, 50: 1142–1150. doi: 10.1002/1097-0142(19820915)50:6<1142::AID-CNCR2820500618>3.0.CO;2-I
Publication History
- Issue published online: 28 JUN 2006
- Article first published online: 28 JUN 2006
- Manuscript Accepted: 13 JUL 1981
Funded by
- Swedish Cancer Society. Grant Number: 93
- Swedish Medical Research Council. Grant Number: 536
- Assar Gabrielsson Foundation
- Swedish Society of Medical Sciences
- Serena Ehrenström Foundation
References
- 1, . Energy and nitrogen metabolism in cancer. Adv Cancer Res 1954; 2: 229–252.
- 2. Theoretical review. Control of food intake in cancer cachexia: A challenge and a tool. Physiol Behav 1976; 17: 705–714.
- 3. Anorexia-producing intermediary metabolites. Am J Clin Nutr 1976; 29: 552–558.
- 4. How tumors affect host metabolism. Ann NY Acad Sci 1974; 230: 86–93.
- 5. Energy metabolism and requirements in the cancer patients. Cancer Res 1977; 37: 2336–2347.
- 6, , . Energy balance and body composition in cancer patients. Cancer Res 1978; 38: 1801–1807.
- 7. Mitochondrial calcium transport and the regulation of metabolism by calcium in tumor cells. In: CrissWE, OnoT, SabineJR (eds). Control Mechanisms in Cancer. New York: Raven Press, 1976; 411–423.
- 8, . Regulation of tumor cell metabolism by the adenylate and guanylate energy charges. In: CrissWE, OnoT, SabineJR (eds). Control Mechanisms in Cancer. New York: Raven Press, 1976; 401–410.
- 9. Cancer cachexia and gluconeogenesis. Ann NY Acad Sci 1974; 230: 103–110.
- 10. Cachexia, gluconeogenesis and progressive weight loss in cancer patients. J Theor Biol 1978; 73: 51–59.
- 11, , , , , . Lactate metabolism in patients with metastatic colorectal cancer. Cancer Res 1979; 39: 4900–4904.
- 12, , , , . Altered glucose metabolism in metastatic carcinoma. Cancer Res 1975; 35: 3710–3714.
- 13, , , , . Qualitative estimation of the Cori cycle in the human. J Biol Chem 1963; 238: 495–501.
- 14. Lactate metabolism in patients with cancer. Cancer 1974; 33: 66–71.
- 15, , . Gluconeogenesis from alanine in patients with progressive malignant disease. Cancer Res 1979; 39: 1968–1972.
- 16, . Hydrazine sulfate in late stage cancer: Completion of initial clinical trials in 225 evaluable patients. Proceedings, Fifteenth Annual Meeting of the American Society of Clinical Oncology 1979; 20: 240.
- 17, , . Evaluation of glucose turnover, body mass and recycling with reversible and irreversible tracers. Biochem J 1974; 142: 161–170.
- 18, , , . Determination of synthesis, recycling and body mass of glucose in rats and rabbits in vivo with 3H- and 14C-labelled glucose. Biochem J 1974; 142: 171–183.
- 19, , , , . Metabolism of neoplastic tissue. XVII: Blood glucose replacement rates in human cancer patients. Cancer Res 1964; 24: 71–76.
- 20, , , , , and . Effects of insulin and tolbutamide on production and utilization of blood sugar. Metabolism 1959; 8: 486–492.
- 21, , , . No inhibition by Li+ of thyroxine monodeiodination to 3,5,3′-triiodothyronine and 3,3′,5′-triiodothyronine (reverse triiodothyronine). Clin Chim Acta 1977; 79: 457–464.
- 22, . Synthesis of phospholipids and triglycerides in human liver slices. I: Experimental conditions and the synthesis rate in normal liver tissue. Scand J Clin Lab Invest 1969; 24: 237–249.
- 23, . Metabolism of glucose in hyper- and hypothyroid rats in vivo: Glucose-turnover values and futile-cycle activities obtained with 14C- and 3H-labelled glucose. Biochem J 1979; 182: 565–575.
- 24. The Spearman rank correlation coefficient. In: HarlowHF, ed. Nonparametric Statistics for the Behavioral Sciences, International Student Ed. New York: McGraw-Hill, 1956; 202–231.
- 25, , , , , . Extrathyroidal conversion of thyroxine to 3,3′,5′-triiodothyronine (reverse-T3) and 3,5,3′-triiodothyronine (reverse-T3) in humans. J Clin Endocrinol Metab 1977; 44: 733–742.
- 26, , . Glucose homeostasis in rats bearing a transplantable sarcoma. Cancer Res 1980; 40: 1699–1706.
- 27, , , , . Relationship of food intake, body composition and tumor growth to host metabolism in nongrowing mice with sarcoma. Cancer Res 1980; 40: 2516–2522.
- 28, . Gluconeogenesis from glycerol in fasting rats. Life Sci 1964; 3: 243–249.
- 29, , . Interrelations in the oxidative metabolism of free fatty acids, glucose, and glycerol in normal and hyperlipemic patients: A comparative model. J Clin Invest 1974; 54: 461–476.
- 30, . Metabolism of glucose in hyper-and hyperthyroid rats in vivo: Relation of catecholamine actions to thyroid activity in controlling glucose-turnover. Biochem J 1979; 182: 585–592.
- 31, . Metabolism of glucose in hyper- and hypothyroid rats in vivo: Minor role of endogenous insulin in thyroid-dependent changes in glucose-turnover. Biochem J 1979; 182: 577–584.
- 32, . Leucine metabolism in skeletal muscle of the tumour-bearing rat. Eur J Cancer 1980; 16: 1153–1162.
- 33, , . Glucose tolerance in relation to skeletal muscle enzyme activities in cancer patients. Scand J Clin Lab Invest 1977; 37: 267–272.
- 34, , , . Skeletal muscle metabolism in patients with malignant tumor. Eur J Cancer 1976; 12: 465–473.
- 35, , . Insulin resistance in patients with cancer. Cancer Res 1978; 38: 4665–4670.
- 36, . The origin of alanine produced in skeletal muscle. J Biol Chem 1978; 253: 3677–3684.
- 37, , . Alanine and glutamine synthesis and release from skeletal muscle. I: Glycolysis and amino acid release. J Biol Chem 1976; 251: 826–835.
- 38, . Protein turnover and amino acid metabolism in the regulation of gluconeogenesis. Fed Proc 1974; 33: 1092–1097.
- 39
- 40, , , , . Physico-chemical properties and isoenzyme composition of hexokinase from normal and malignant human tissues. J Natl Cancer Inst 1978; 61: 27–33.

1097-0142/asset/olbannerleft.gif?v=1&s=ca681f5719430b26e1bc15e9ea4c9fc0a7110104)
1097-0142/asset/olbannerright.gif?v=1&s=8142566facf7e76aef9be6c51162a2e920b3b9f9)
1097-0142/asset/cover.gif?v=1&s=a7299bc18f075294c232ade468773cd0672bd470)