Malignant fibrous histiocytoma of the breast. A case report and review of the literature

Authors

  • Max R. Langham Jr MD,

    Corresponding author
    1. Divisions of Surgical Oncology and Surgical Pathology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia
    • Medical College of Virginia, P.O. Box 645, MCV Station, Richmond, VA 23298
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    • Resident in Surgery, Medical College of Virginia.

  • A. Scott Mills MD,

    1. Divisions of Surgical Oncology and Surgical Pathology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia
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    • Instructor, Department of Pathology, Medical College of Virginia.

  • Richard M. Demay MD,

    1. Divisions of Surgical Oncology and Surgical Pathology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia
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    • Assistant Professor, Department of Pathology, Medical College of Virginia.

  • Gerard J. O'Dowd MD,

    1. Divisions of Surgical Oncology and Surgical Pathology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia
    Current affiliation:
    1. Department of Pathology, George Washington University Medical Center
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    • Fellow in Cytology and Surgical Pathology, Department of Pathology, Medical College of Virginia.

  • Mark A. Grathwohl MD,

    1. Divisions of Surgical Oncology and Surgical Pathology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia
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    • Resident, Department of Pathology, Medical College of Virginia.

  • J. Shelton Horsley III MD

    1. Divisions of Surgical Oncology and Surgical Pathology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia
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    • Professor of Surgery, Division of Surgical Oncology, Medical College of Virginia.


Abstract

The clinicopathologic features of a malignant fibrous histiocytoma arising in a female breast are presented. Seven cases have been previously reported. These may be divided into three subgroups based on history and pathologic findings. Three of the seven occurred in women without a history of other tumors or previous irradiation. One appeared with a cytosarcoma phyllodes, and three arose following radiation for carcinoma of the breast. The patient in this study had received no radiation. Treatment has been based on surgical resection; the roles of chemotherapy and radiation are uncertain. Although resection alone in the first subgroup has lead to no reported mortality, the small number of cases and the relatively short follow-up does not allow a meaningful assessment of the prognosis in this disease.

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