Female gender is a major determinant of changing subsite distribution of colorectal cancer with age

Authors

  • David Butcher MD,

    1. Departments of Medicine and of Biometry, College of Health Sciences, University of Kansas, Kansas City, Kansas
    Search for more papers by this author
  • Khatab Hassanein PHD,

    1. Departments of Medicine and of Biometry, College of Health Sciences, University of Kansas, Kansas City, Kansas
    Search for more papers by this author
  • Maureen Dudgeon MD,

    1. Departments of Medicine and of Biometry, College of Health Sciences, University of Kansas, Kansas City, Kansas
    Search for more papers by this author
  • James Rhodes MD,

    1. Departments of Medicine and of Biometry, College of Health Sciences, University of Kansas, Kansas City, Kansas
    Search for more papers by this author
  • Frederick F. Holmes MD

    Corresponding author
    1. Departments of Medicine and of Biometry, College of Health Sciences, University of Kansas, Kansas City, Kansas
    • Department of Medicine, University of Kansas Medical Center, Kansas City, KS 66103
    Search for more papers by this author

Abstract

Distribution by subsite and sector of 948 colorectal cancers diagnosed in Kansas in 1982 was analyzed in respect to sex and age in a population-based study. Regression analysis of percentage versus age showed decreasing left, increasing right, and unchanged transverse colon occurrence of cancer for both sexes. However, this was statistically significant only for women; left, −0.7066% per year (P = 0.0088) and right +0.6023% per year (P = 0.0012). Regression for seven subsites showed significant changes only for women; with rectosigmoid and sigmoid decreasing and cecum and ascending colon increasing. Similar results were obtained in analysis of the 5822 cases available in the Kansas cancer registry for the years 1978 to 1982. These findings have important implications for screening and diagnosis of colorectal cancer in the elderly, particularly women, and also provide a useful clue in the investigation of colorectal carcinogenesis.

Ancillary