Neuroendocrine features in poorly differentiated and undifferentiated carcinomas of the cervix

Authors

  • Rolland J. Barrett II MD,

    Corresponding author
    1. Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, California
    Current affiliation:
    1. Department of Obstetrics and Gynecology, Section on Gynecologic Oncology, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina
    • Section on Gynecologic Oncology, Bowman Gray School of Medicine, 300 South Hawthorne Road, Winston-Salem, NC 27103
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  • Irene Davos MD,

    1. Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, California
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  • Ronald S. Leuchter MD,

    1. Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, California
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  • Leo D. Lagasse MD

    1. Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, California
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Abstract

Neuroendocrine or argyrophil cell carinoma of the cervix has recently been accepted as a distinct clinical-pathological entity. The histologic pattern of these carcinomas is usually poorly differentiated or undifferentiated. Twenty patients with a histologic diagnosis of small cell carcinoma, undifferentiated carcinoma, poorly differentiated adenocarcinoma, or poorly differentiated, adenosquamous carcinoma of the cervix were evaluated for neuroendocrine features. The results of studies to detect neurosecretory granules were positive in seven of the 20 cases. Not only small cell carcinomas, but also tumors classified as undifferentiated carcinoma and poorly differentiated, adenosquamous carcinoma contained cytoplasmic granules consistent with neuroendocrine carcinoma of the cervix. The prognosis for survival appears poorer for patients having tumors with neurosecretory granules after controlling for stage and histologic grade of the neoplasm.

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