Clinical Research Center.
Symptoms potentially influencing weight loss in a cancer population. Correlations with primary site, nutritional status, and chemotherapy administration
Article first published online: 28 JUN 2006
Copyright © 1989 American Cancer Society
Volume 63, Issue 2, pages 330–334, 15 January 1989
How to Cite
Grosvenor, M., Bulcavage, L. and Chlebowski, R. T. (1989), Symptoms potentially influencing weight loss in a cancer population. Correlations with primary site, nutritional status, and chemotherapy administration. Cancer, 63: 330–334. doi: 10.1002/1097-0142(19890115)63:2<330::AID-CNCR2820630221>3.0.CO;2-U
- Issue published online: 28 JUN 2006
- Article first published online: 28 JUN 2006
- Manuscript Accepted: 28 JUL 1988
- NIH. Grant Numbers: CA37320, RR00425, AE35738
A nutritional assessment including determination of symptoms potentially influencing weight loss was prospectively performed on 254 consecutive cancer patients with favorable performance scores (Eastern Cooperative Oncology Group [ECOG] level 0 to 2). Primary cancer sites included the following: non-small cell lung (n = 93), colon (n = 50), prostate (n = 23), oropharyngeal (n = 18), breast (n = 15), gastrointestinal (n = 13), and other (n = 42). Thirty-nine percent of patients had received no prior chemotherapy or radiation therapy. Common symptoms in the population were abdominal fullness (61%), taste change (46%), constipation (41%), mouth dryness (40%), nausea (39%), and vomiting (27%). Current caloric intake was surprisingly similar in 170 patients with weight loss (percent usual body weight [PUBW], ≤95%) compared with 84 without weight loss (PUBW, >95%; 31.4 ± 1.5 versus 30.5 ± 2.1 kcal/kg/d, respectively). Symptoms identified by multivariate analysis as occurring significantly more frequently in populations with weight loss included abdominal fullness (P < 0.001), taste change (P < 0.002), vomiting (P < 0.005), and mouth dryness (P < 0.02). There was no difference in frequency of symptoms between patients with or without prior chemotherapy. These results indicate that gastrointestinal/oral symptoms potentially influencing weight loss are prevalent early in the course of cancer patients with unresectable disease, regardless of current nutritional status, caloric intake, or prior therapy experience.