Research Fellow, Department of Urology, University Hospital, Nijmegen, The Netherlands.
Analysis of prognostic factors in disseminated prostatic cancer. An update
Article first published online: 28 JUN 2006
Copyright © 1990 American Cancer Society
Volume 65, Issue 12, pages 2758–2761, 15 June 1990
How to Cite
Mulders, P. F. A., Dijkman, G. A., Moral, P. F. D., Theeuwes, A. G. M. and Debruyne, F. M. J. (1990), Analysis of prognostic factors in disseminated prostatic cancer. An update. Cancer, 65: 2758–2761. doi: 10.1002/1097-0142(19900615)65:12<2758::AID-CNCR2820651225>3.0.CO;2-6
- Issue published online: 28 JUN 2006
- Article first published online: 28 JUN 2006
- Manuscript Accepted: 19 DEC 1989
A statistical analysis of prognostic factors in 175 patients with hormonally treated disseminated prostatic cancer was done. The prognostic significance of performance status (PS), hemoglobin (Hb), alkaline phosphatase (Alk P), and testosterone was assessed with a univariate analysis. The authors did not find significant prognostic value in age, tumor size or grade, prostatic acid phosphatase, and prostate-specific antigen in these patients. In a multivariate logistic model (Cox regression), PS, Hb, and Alk P were found useful for dividing patients into prognostic groups. The prognosis for high-risk patients on standard hormonal treatment was very poor. The authors concluded that research on prognostic factors is useful and permits a division of patients into risk groups that makes choice of treatment more accurate. The use of new treatment combinations as a start treatment is appropriate for high-risk patients with disseminated prostatic cancer.