Successful treatment of angioimmunoblastic lymphadenopathy with dysproteinemia with cyclosporin A

Authors

  • Tohru Murayarna MD,

    Corresponding author
    1. Division of Hematology/Oncology, Department of Internal Medicine, Hyogo Medical Center for Adults, Akashi, Hyogo, Japan
    • Hematology/Oncology Division, Department of Medicine, Hyogo Medical Center for Adults, 13-70 Kita-Oji, Akashi, Hyogo, Japan, 673
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  • Shion Lmoto MD,

    1. Division of Hematology/Oncology, Department of Internal Medicine, Hyogo Medical Center for Adults, Akashi, Hyogo, Japan
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  • Tetsuya Takahashi MD,

    1. Division of Hematology/Oncology, Department of Internal Medicine, Hyogo Medical Center for Adults, Akashi, Hyogo, Japan
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  • Mitsuhiro Ito MD,

    1. Division of Hematology/Oncology, Department of Internal Medicine, Hyogo Medical Center for Adults, Akashi, Hyogo, Japan
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  • Sachiko Matozaki MD,

    1. Division of Hematology/Oncology, Department of Internal Medicine, Hyogo Medical Center for Adults, Akashi, Hyogo, Japan
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  • Toshitaro Nakagawa MD

    1. Division of Hematology/Oncology, Department of Internal Medicine, Hyogo Medical Center for Adults, Akashi, Hyogo, Japan
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Abstract

Angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) is a lymphoma-like disease. Although the histologic appearance of this disease is benign, it is clinically malignant, with chemotherapy being ineffective and the prognosis being poor. In this article, the authors report the results of treating two patients with AILD with cyclosporin A. One patient had cervical lymphadenopathy and fever, and AILD was refractory to both chemotherapy and a-interferon. However, treatment with cyclosporin A achieved complete remission. The other patient had generalized lymphadenopathy, and cyclosporin A was used as the treatment of first choice. Complete remission also was achieved in this patient, who still is in remission. These two cases demonstrate that cyclosporin A can be effective for treating AILD.

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