Prognostic significance of histologic parameters of soft tissue sarcomas
Article first published online: 29 JUN 2006
Copyright © 1992 American Cancer Society
Volume 70, Issue 12, pages 2816–2822, 15 December 1992
How to Cite
Hashimoto, H., Daimaru, Y., Takeshita, S., Tsuneyoshi, M. and Enjoji, M. (1992), Prognostic significance of histologic parameters of soft tissue sarcomas. Cancer, 70: 2816–2822. doi: 10.1002/1097-0142(19921215)70:12<2816::AID-CNCR2820701215>3.0.CO;2-4
- Issue published online: 29 JUN 2006
- Article first published online: 29 JUN 2006
- Manuscript Accepted: 11 JUN 1992
- soft tissue sarcoma;
- multivariate analysis;
- histologic parameters
Background and Methods. A univariate and multi-variate analysis for the correlation between histomorphologic factors and prognosis was made using data from 1116 patients with soft tissue sarcoma, including 1005 cases available with complete histologic and follow-up data.
Results. The overall 5-year survival rate was 43.6%. The univariate analysis using Kaplan-Meier survival curves showed that tumor differentiation, cellularity, nuclear atypia, cellular pleomorphism, mitotic activity, amount of fibrous stroma, extent of myxoid areas, extent of tumor necrosis, and histologic grading (determined by the estimated range of malignancy for each type of sarcoma using a reported guideline) were all significant prognostic factors in the overall soft tissue sarcoma group. By a multivariate analysis using a procedure based on the Weibull model to failure data, the histologic grading and extent of tumor necrosis were proved to be prognostically significant in the overall sarcoma group. However, after additional analysis on each histologic type of sarcoma, it was determined that both tumor necrosis and histologic grading were applicable in only two types: malignant fibrous histiocytoma and leiomyosarcoma. Liposarcoma, synovial sarcoma, and malignant schwannoma each also showed some determinable factor of prognostic significance.
Conclusions. It was concluded that there seemed to be no single universal prognostic parameter that could be applied to each soft tissue sarcoma type. These results suggest that the predictive significance of the various histologic parameters should be based on each specific type of sarcoma.