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Original Article
The effects of cyclooxygenase inhibitors on tumor-induced anorexia in rats
Article first published online: 28 JUN 2006
DOI: 10.1002/1097-0142(19930115)71:2<486::AID-CNCR2820710233>3.0.CO;2-A
Copyright © 1993 American Cancer Society
1097-0142/asset/cover.gif?v=1&s=a7299bc18f075294c232ade468773cd0672bd470 "Cancer")
Additional Information
How to Cite
McCarthy, D. O. and Daun, J. M. (1993), The effects of cyclooxygenase inhibitors on tumor-induced anorexia in rats. Cancer, 71: 486–492. doi: 10.1002/1097-0142(19930115)71:2<486::AID-CNCR2820710233>3.0.CO;2-A
Publication History
- Issue published online: 28 JUN 2006
- Article first published online: 28 JUN 2006
- Manuscript Accepted: 1 JUN 1992
Funded by
- American Institute for Cancer Research. Grant Number: NR02258
- National Institutes of Health
- Abstract
- References
- Cited By
Keywords:
- Walker 256;
- rats;
- anorexia;
- tumor growth;
- prostaglandins
Abstract
Background. Interleukin-1 (IL-1) and tumor necrosis factor (TNF) are potent induces of prostaglandin (PG) synthesis and injection of PGE, IL-1, or TNF decreases food intake in healthy animals, whereas the anorexigenic effects of injected IL-1 and TNF are blocked by inhibitors of PG synthesis. It has been hypothesized that host secretion of IL-1 and TNF contribute to tumor-induced anorexia. This study was undertaken to determine whether administration of PG inhibitors alters food intake in anorectic rats implanted with Walker 256 carcinoma.
Methods. Groups of six tumor-bearing rats were implanted with slow-release pellets containing ibuprofen, indomethacin, or acetylsalicylic acid. Food intake, tumor growth, and body temperature were monitored for 14 days and compared with control tumor-bearing animals implanted with placebo pellets.
Results. Tumor growth was associated with anorexia, fever, wieght loss, and increased leukocyte secretion of IL-1 and TNF. Indomethacin and ibuprofen retarded tumor growth 30–40% and lowered body temperature compared with controls, but had no effect on food intake or body weight of tumor-bearing animals.
Conclusions. Prostaglandins do not mediate tumorinduced anorexia.