Gliosarcoma with features of chondroblastic osteosarcoma
Article first published online: 28 JUN 2006
Copyright © 1993 American Cancer Society
Volume 72, Issue 3, pages 850–855, 1 August 1993
How to Cite
Hayashi, K., Ohara, N., Jeon, H. J., Akagi, S., Takahashi, K., Takahashi, K., Akagi, T. and Namba, S. (1993), Gliosarcoma with features of chondroblastic osteosarcoma. Cancer, 72: 850–855. doi: 10.1002/1097-0142(19930801)72:3<850::AID-CNCR2820720334>3.0.CO;2-4
- Issue published online: 28 JUN 2006
- Article first published online: 28 JUN 2006
- Manuscript Accepted: 22 MAR 1993
- glial fibrillary acidic protein;
- electron microscopy
Background. The occurrence of osteoid-chondral elements in gliosarcoma is extremely rare and has been reported in only two cases. A new, rare case of gliosarcoma with osteosarcomatous differentiation in a 55-year-old man and histogenesis of osteoid-chondral tissue in gliosarcoma is discussed.
Methods. Surgically removed tumor tissues were examined immunohistochemically and electron microscopically, and a histologic examination was performed.
Results. Immunohistochemical and electron microscopic studies confirmed the presence of glial, fibroblastic, and osteoid-chondral elements. A major part of the sarcomatous tissue was undifferentiated and stained only by vimentin. Some areas of osteoid-chondral tissue were positive for glial fibrillary acidic protein (GFAP).
Conclusions. These data suggest that osteoid-chondral elements came from the sarcomatous portion and GFAP positivity is not restricted to astrocytes and has been seen particularly in chondroid areas of non-glial tumors.