Sypported by the Leukaemia Research Lund.
Parvovirus B19 as a cause of chronic anemia in rhabdomyosarcoma
Article first published online: 28 JUN 2006
Copyright © 1993 American Cancer Society
Volume 72, Issue 3, pages 945–949, 1 August 1993
How to Cite
Shaw, P. J., Eden, T. and Cohen, B. J. (1993), Parvovirus B19 as a cause of chronic anemia in rhabdomyosarcoma. Cancer, 72: 945–949. doi: 10.1002/1097-0142(19930801)72:3<945::AID-CNCR2820720346>3.0.CO;2-H
- Issue published online: 28 JUN 2006
- Article first published online: 28 JUN 2006
- Manuscript Accepted: 16 MAR 1993
- Leukaemia Research Fund
- parvovirus infections;
- childhood tumors;
- aplastic crisis;
Background. Several reports have been published of anemia due to infection by parvovirus in patients receiving chemotherapy for leukemia. However, parvovirus B19 has not been previously identified as a cause of chronic anemia in children with solid tumors.
Methods. A child with rhabdomyosarcoma developed chronic anemia, with need for regular blood transfusions during chemotherapy. An infectious etiology was sought.
Results. B19 viremia and an absent antibody response was present during the period of chronic anemia during chemotherapy. After completion of chemotherapy, the viremia cleared, IgM and IgG antibody to B19 virus were detected, and the anemia resolved.
Conclusions. Parvovirus must be considered as a cause of anemia in patients undergoing chemotherapy for solid tumors as well as leukemia.