• Please log in or register to access this feature.

Original Article

You have full text access to this OnlineOpen article

Proliferating cell nuclear antigen in hepatocellular carcinoma and small cell liver dysplasia

  1. Eisuke Adachi M.D.,
  2. Hiroshi Hashimoto M.D.†,
  3. Masazumi Tsuneyoshi M.D.*

Article first published online: 28 JUN 2006

DOI: 10.1002/1097-0142(19931115)72:10<2902::AID-CNCR2820721008>3.0.CO;2-2

Issue

Cancer

Cancer

Volume 72, Issue 10, pages 2902–2909, 15 November 1993

Additional Information

How to Cite

Adachi, E., Hashimoto, H. and Tsuneyoshi, M. (1993), Proliferating cell nuclear antigen in hepatocellular carcinoma and small cell liver dysplasia. Cancer, 72: 2902–2909. doi: 10.1002/1097-0142(19931115)72:10<2902::AID-CNCR2820721008>3.0.CO;2-2

Author Information

  1. Second Department of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan

  1. †

    First Department of Pathology, University of Occupational and Environmental Health, School of Medicine, 1-1, lesigaoka, Yahatanishi-ku, Kitakyushu 807, Japan

*The Second Department of Pathology, Faculty of Medicine, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812, Japan

Publication History

  1. Issue published online: 28 JUN 2006
  2. Article first published online: 28 JUN 2006
  3. Manuscript Accepted: 24 JUN 1993

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

Get PDF (1215K)

References

  • 1
    Miyachi K, Fritzler MJ Tan EM. Autoantibody to a nuclear antigen in proliferating cells. J Immunol 1978; 121: 2228–34.
  • 2
    Mathews B, Bernstein RM, Franza BR, Gerrels JI. Identity of the proliferating cell nuclear antigen and cyclin. Nature 1984; 309: 374–6.
  • 3
    Prelich G, Tan CK, Kotsura M, Mathews MB, So AG, Downey KM, et al. Functional identity of proliferating cell nuclear antigen and a DNA polymerase-delta auxiliary protein. Nature 1987; 326: 517–20.
  • 4
    Hall PA, Levinson DA. Review: assessment of cell proliferation in histological material. J Clin Pathol 1990; 43: 184–92.
  • 5
    Waseem NH, Lane DP. Monoclonal antibody analysis of the proliferating cell nuclear antigen (PCNA): structural conservation and the detection of a nucleolar form. J Cell Sci 1990; 96: 121–9.
  • 6
    Hall PA, Levinson DA, Wood AL. Proliferating cell nuclear antigen in paraffin sections: an index of cell proliferation with evidence of deregulated expression in some neoplasms. J Pathol 1990; 162: 285–94.
    Direct Link:
  • 7
    Galand P, Degrae C. Cyclin/PCNA immunostaining as an alternative to tritiated thymidine pulse labelling for marking S phase cells in paraffin sections from animal and human tissues. Cell Tissue Kinet 1989; 22: 382–92.
  • 8
    Woods AL, Hall PA, Shepherd NA, Hanby AM, Wassem NH, Lane DP, et al. The assessment of proliferating cell nuclear antigen (PCNA) immunostaining in primary gastrointestinal lymphomas and its relationship to histological grade, S+G2+M phase fraction (flow cytometric analysis) and prognosis. Histopathology 1991; 19: 21–7.
    Direct Link:
  • 9
    Yu CCW, Hall PA, Fletcher CDM, Camplejohns RS, Waseem NH, Lane DP, et al. Heamangiopericytomas: the prognostic value of immunohistochemical staining with a monoclonal antibody to proliferating cell nuclear antigen (PCNA). Histopathology 1991; 19: 29–33.
    Direct Link:
  • 10
    Jain S, Fillipe MI, Hall PA, Waseem N, Lane DP, Levinson DA. Prognostic value of proliferating cell nuclear antigen in gastric carcinoma. J Clin Pathol 1991; 44: 655–9.
  • 11
    Watanabe S, Okita K, Harada T, Kodama T, Numa Y, Takemoto T, et al. Morphologic studies of the liver cell dysplasia. Cancer 1983; 51: 2197–205.
    Direct Link:
  • 12
    Farber E. The multistep nature of cancer development. Cancer Res 1976; 44: 4217–23.
  • 13
    Edmondson HA, Steiner PE. Primary carcinoma of the liver: a study of 100 cases among 48900 necropsies. Cancer 1954; 7: 462–503.
    Direct Link:
  • 14
    Kenmochi K, Sugihara S, Kojiro M. Relationship of histological grade of hepatocellular carcinoma (HCC) to tumor size, and demonstration of tumor cells of multistep different grades in single small HCC. Liver 1987; 7: 18–26.
  • 15
    Benjamin DR, Gown AM. Aberrant cytoplasmic expression of proliferating cell nuclear antigen in Hodgkin's disease. Am J Surg Pathol 1991; 15: 764–8.
  • 16
    Seki S, Sakaguchi H, Kawakita N, Yanai A, Kim K, Mizoguchi Y, et al. Identification and fine structure of proliferating hepatocytes in malignant and nonmalignant liver diseases by use of a monoclonal antibody against DNA polymerase alpha. Hum Pathol 1990; 21: 1020–30.
  • 17
    Kawakita N, Seki S, Sakaguchi H, Kuroki T, Mizoguchi Y, Kobayashi K, et al. Analysis of proliferating hepatocytes using a monoclonal antibody against proliferating cell nuclear antigen/cyclin in embedded tissue from various liver diseases fixed in formaldehyde. Am J Pathol 1992; 140: 513–20.
  • 18
    Eguchi A, Nakashima O, Okudaira S, Sugihara S, Kojiro M. Adenomatous hyperplasia in the vicinity of small hepatocellular carcinoma. Hepatology 1992; 15: 843–8.
    Direct Link:
  • 19
    Terada T, Nakanuma Y. Cell proliferative activity in adenomatous hyperplasia of the liver and small hepatocellular carcinoma: an immunohistochemical study demonstrating proliferating cell nuclear antigen. Cancer 1992; 70: 591–8.
    Direct Link:
Get PDF (1215K)