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Cancer

Cover image for Cancer

1 July 2000

Volume 89, Issue 1

Pages 1–227

  1. Commentary

    1. Top of page
    2. Commentary
    3. Original Articles
    4. Communication
    5. Correspondence
    1. You have free access to this content
      Comparative analysis of thyroid carcinoma in Germany and the U.S. (pages 1–4)

      Blake Cady

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000701)89:1<1::AID-CNCR1>3.0.CO;2-5

      Germany and the U.S. differ considerably in several aspects with regard to the presentation and treatment of thyroid carcinoma. Germany, which to this day does not iodize table salt, has many areas with continuing iodine deficiency and therefore a different pattern of differentiated thyroid carcinoma with more follicular and fewer papillary cases and a higher risk of anaplastic carcinoma. Surgical therapy in Germany and the U.S. appears to be unrelated to the stage of disease or the seriousness of the tumor. TNM staging could be utilized in both countries to distinguish patients at low risk who require less aggressive surgery and radioactive iodine from those patients at high risk who may benefit from more aggressive treatment, both surgical and radiotherapeutic.

      See also pages 192–201 and 202–17.

  2. Original Articles

    1. Top of page
    2. Commentary
    3. Original Articles
    4. Communication
    5. Correspondence
    1. Anatomic Site

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      Loss of fragile histidine triad gene expression is associated with progression of esophageal squamous cell carcinoma, but not with the patient's prognosis and smoking history (pages 5–11)

      Yutaka Shimada, Fumiaki Sato, Go Watanabe, Seiji Yamasaki, Masayuki Kato, Masato Maeda and Masayuki Imamura

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000701)89:1<5::AID-CNCR2>3.0.CO;2-Z

      This study evaluated the clinical impact of the fragile histidine triad (FHIT) gene in 149 esophageal squamous cell carcinoma (SCC) patients retrospectively using immunohistochemical analysis. The data suggested that FHIT protein expression was associated with progression of esophageal SCC; however, it may not be associated with the patient's prognosis.

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      Gastric lymphomas in Turkey : Analysis of prognostic factors with special emphasis on flow cytometric DNA content (pages 12–20)

      Zeynep Dilek Aydin, Ibrahim Barista, Hande Canpinar, Arzu Sungur and Gülten Tekuzman

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000701)89:1<12::AID-CNCR3>3.0.CO;2-Y

      To the authors' knowledge the current study is the first to demonstrate the prognostic significance of S-phase fraction (SPF) for gastric lymphomas and some distinct features of DNA flow cytometric analysis in Turkish gastric lymphoma patients. In addition to the lower percentage of aneuploid cases and higher SPFs found in this series of Turkish gastric lymphoma patients, the most distinguishing feature was DNA index values of aneuploid cases that all were < 1.0.

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      Changes in P-glycoprotein expression in gastric carcinoma with respect to distant gastric mucosa may be influenced by p53 (pages 21–28)

      F. Javier Lacueva, Rafael Calpena, Justo Medrano, Ana Teruel, M. Jose Mayol, M. Luisa Graells, M. Vicenta Camarasa, M. Teresa Perez-Vazquez and Jose A. Ferragut

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000701)89:1<21::AID-CNCR4>3.0.CO;2-T

      P-glycoprotein (P-gp) expression in gastric carcinomas is frequent and is coexpressed with p53. P-gp seems not to be regulated by p53, but a loss of P-gp detected in some of these carcinomas is mainly associated with a lack of p53 protein accumulation.

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      Concomitant chemoradiation treatment in the management of patients with extrahepatic biliary tract recurrence of gastric carcinoma (pages 29–34)

      Su-Shun Lo, Chew-Wun Wu, Kwan-Hwa Chi, Hsiuo-Shan Tseng, King-Han Shen, Mao-Chih Hsieh and Wing-Yiu Lui

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000701)89:1<29::AID-CNCR5>3.0.CO;2-I

      Satisfactory palliation can be achieved by concomitant chemoradiation for patients with obstructive jaundice resulting from extrahepatic biliary metastases of gastric carcinoma, hence providing an alternative treatment choice for these patients.

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      Tumor thickness is a histopathologic predictive parameter of tumor metastasis and prognosis in patients with Dukes Stage C ulcerative-type colorectal carcinoma : A two-hospital–based study (pages 35–45)

      Takahiro Hasebe, Masato Morihiro, Satoshi Sasaki, Tadakazu Shimoda, Masanori Sugitoh, Yoshihiro Moriya, Masato Ono, Tatsuo Arai and Atsushi Ochiai

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000701)89:1<35::AID-CNCR6>3.0.CO;2-G

      The tumor thickness in patients with colorectal carcinoma is a useful parameter for predicting metachronous liver metastases, multiple lymph node metastases, and overall survival in patients with Dukes C colorectal carcinoma.

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      Comparative screening with a sensitive guaiac and specific immunochemical occult blood test in an endoscopic study (pages 46–52)

      Paul Rozen, Judith Knaani and Ziona Samuel

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000701)89:1<46::AID-CNCR7>3.0.CO;2-9

      The guaiac fecal occult blood test HemoccultSENSA, which does not require dietary restrictions, is significantly more sensitive for colorectal neoplasms than the immunochemical test FlexSure OBT, which is specific to human hemoglobin. (Both tests are manufactured by Beckman-Coulter Inc., Primary Care Diagnostics, Palo Alto, CA.) The former identifies more adenomas with a lower specificity, but it is still acceptable and suitable for population screening.

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      Analysis of factors affecting the appearance of hepatocellular carcinoma in patients with chronic hepatitis C : A long term follow-up study after histologic diagnosis (pages 53–59)

      Yoshio Aizawa, Yuka Shibamoto, Ichiro Takagi, Mikio Zeniya and Gotaro Toda

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000701)89:1<53::AID-CNCR8>3.0.CO;2-6

      In patients with chronic hepatitis C, the annual incidence rate of hepatocellular carcinoma (HCC) was found to increase as the follow-up period progressed. The factors that independently affected the development of HCC were age, habitual heavy drinking, and histologic staging.

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      p16 is a major inactivation target in hepatocellular carcinoma (pages 60–68)

      Myung Jin Baek, Zhe Piao, Nam-Gyun Kim, Chanil Park, Eui-Cheol Shin, Jeon-Han Park, Hee-Jung Jung, Chul Geun Kim and Hoguen Kim

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000701)89:1<60::AID-CNCR9>3.0.CO;2-3

      Among the 3 cell cycle regulator proteins encoded at the 9p21 genetic locus, the inactivation of p16 is the most frequent event in hepatocellular carcinomas in which promoter methylation and homozygous deletions are the common mechanisms.

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      Six-year recurrence free survival after intraluminal iridium-192 therapy of human bilobar biliary papillomatosis : A case report (pages 69–73)

      Peter Gunvén, Jakob Gorsetman, Hans Ohlsén, Bengt-Inge Rudén, Göran Lundell and Lambert Skoog

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000701)89:1<69::AID-CNCR10>3.0.CO;2-9

      More than 6 years of recurrence free survival resulted from bulk reduction of bilobar biliary papillomatosis by cholangioscopic electrocoagulation followed by intraluminal iridium-192 brachytherapy. This seems to be the first case of successful nonoperative treatment of this exceedingly rare and mostly fatal disease; in this patient, the possibility of resecting the disease by a major liver resection would have been questionable.

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      Epidermal growth factor receptor blockade by antibody IMC-C225 inhibits growth of a human pancreatic carcinoma xenograft in nude mice (pages 74–82)

      Jay P. Overholser, Marie C. Prewett, Andrea T. Hooper, Harlan W. Waksal and Daniel J. Hicklin

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000701)89:1<74::AID-CNCR11>3.0.CO;2-K

      The anti-epidermal growth factor (EGF) receptor monoclonal antibody IMC-C225 inhibited the growth of human pancreatic carcinoma xenografts in athymic mice. This report demonstrates the potential for therapeutic application of EGF receptor antagonists in the treatment of human pancreatic carcinoma.

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      Tissue polypeptide specific antigen (TPS), a marker for differentiation between pancreatic carcinoma and chronic pancreatitis : A comparative study with CA 19-9 (pages 83–88)

      Barbara Slesak, Antonina Harlozinska-Szmyrka, Witold Knast, Pawel Sedlaczek, Arie van Dalen and Roland Einarsson

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000701)89:1<83::AID-CNCR12>3.0.CO;2-J

      In this differential diagnosis study of pancreatic carcinoma and chronic pancreatitis, tissue polypeptide specific antigen at an elevated upper reference level demonstrated significantly higher sensitivity and specificity for disease differentiation than CA 19-9.

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      Phase II study of paclitaxel and epirubicin as first-line treatment in patients with metastatic nonsmall cell lung carcinoma (pages 89–96)

      Giovanni L. Ceresoli, Stefania Dell'Oro, Paolo Passoni and Eugenio Villa

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000701)89:1<89::AID-CNCR13>3.0.CO;2-Z

      The combination of paclitaxel and epirubicin is effective and well tolerated in chemotherapy-naive patients with metastatic nonsmall cell lung carcinoma.

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      c-MYC and nodular malignant melanoma : A case report (pages 97–103)

      Karin M. Greulich, Jochen Utikal, Ralf-Uwe Peter and Gertraud Krähn

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000701)89:1<97::AID-CNCR14>3.0.CO;2-0

      In this study, the relevance of the c-MYC gene in a case of nodular malignant melanoma was evaluated. A copy number gain of the gene was observed, which also resulted in overexpression of c-MYC mRNA in the tumor tissue.

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      Carcinoembryonic antigen immunoscintigraphy complements mammography in the diagnosis of breast carcinoma (pages 104–115)

      David M. Goldenberg, Hani Abdel-Nabi, Cynthia L. Sullivan, Aldo Serafini, David Seldin, Bruce Barron, Lamk Lamki, Bruce Line and William A. Wegener

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000701)89:1<104::AID-CNCR15>3.0.CO;2-E

      Carcinoembryonic antigen antibody imaging may be useful as a noninvasive adjunctive test in certain women with suspected breast carcinoma after mammography.

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      Patterns of recurrence in patients with squamous cell carcinoma of the vulva : A multicenter CTF study (pages 116–122)

      Tiziano Maggino, Fabio Landoni, Enrico Sartori, Paolo Zola, Angiolo Gadducci, Chiara Alessi, Marika Soldà, Stefania Coscio, Giovanna Spinetti, Andrea Maneo, Annamaria Ferrero and Giuseppe Konishi de Toffoli

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000701)89:1<116::AID-CNCR16>3.0.CO;2-4

      Survival analysis of recurrent disease has shown that the surgical resection of local recurrence may provide acceptable results. The presence of multiple recurrences other than local recurrences represents a subgroup of patients with a poor prognosis. Follow-up is justified with the aim of detecting early local recurrence. Prognostic factors for recurrence include site of disease, lymph node involvement, time of recurrence, and multiple lesions.

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      Antioxidant enzyme expression and reactive oxygen species damage in prostatic intraepithelial neoplasia and cancer (pages 123–134)

      David G. Bostwick, Erik E. Alexander, Rohini Singh, Ailin Shan, Junqi Qian, Regina M. Santella, Larry W. Oberley, Tao Yan, Weixiong Zhong, Xiaohong Jiang and Terry D. Oberley

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000701)89:1<123::AID-CNCR17>3.0.CO;2-9

      Three major antioxidant enzymes—copper-zinc superoxide dismutase, manganese superoxide dismutase, and catalase—had lower expression in prostatic intraepithelial neoplasia and prostate carcinoma than in benign epithelium. The findings of this study suggest that oxidative stress is an early event in carcinogenesis.

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      Modern prostate brachytherapy : Prostate specific antigen results in 219 patients with up to 12 years of observed follow-up (pages 135–141)

      Haakon Ragde, Leroy J. Korb, Abdel-Aziz Elgamal, Gordon L. Grado and Brad S. Nadir

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000701)89:1<135::AID-CNCR18>3.0.CO;2-#

      Modern transperineal prostate brachytherapy results now have been extended to 12 years for patients with clinically localized disease. Utilizing the appropriate addition of external beam radiation in selected brachytherapy patients, disease free survival in the population appears to be excellent.

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      The management and outcome of bladder carcinoma in Ontario, 1982–1994 (pages 142–151)

      Charles R. Hayter, Lawrence F. Paszat, Patti A. Groome, Karleen Schulze and William J. Mackillop

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000701)89:1<142::AID-CNCR19>3.0.CO;2-4

      The current study describes the treatment and outcome of all cases of invasive bladder carcinoma diagnosis in Ontario, Canada between 1982–1994. To the authors' knowledge this is the first population-based study of its kind.

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      Increased glyceraldehyde-3-phosphate dehydrogenase expression in renal cell carcinoma identified by RNA-based, arbitrarily primed polymerase chain reaction (pages 152–164)

      Maya R. Vilà, Antoni Nicolás, Joan Morote, Inés de Torres and Anna Meseguer

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000701)89:1<152::AID-CNCR20>3.0.CO;2-T

      Analysis of differential gene expression among normal and tumor human kidney tissues revealed that glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a potent marker of cell proliferation in kidney tumor cells whose overexpression appears to be a late event in the development of renal cell carcinoma.

    20. General Topic

      Calcium Channel Blockers and Cancer Risk
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      Cancer risk and mortality in users of calcium channel blockers : A cohort study (pages 165–170)

      Henrik T. Sørensen, Jørgen H. Olsen, Lene Mellemkjær, Ane Marie Thulstrup, Flemming H. Steffensen, Joseph K. McLaughlin and John A. Baron

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000701)89:1<165::AID-CNCR21>3.0.CO;2-G

      In this large-scale, population-based cohort study comprising 23,167 subjects, no association was determined between calcium channel blockers and cancer risk or mortality.

    21. Cancer Tissue Metabolism
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      The accumulation of ascorbic acid by squamous cell carcinomas of the lung and larynx is associated with global methylation of DNA (pages 171–176)

      Chandrika J. Piyathilake, Walter C. Bell, Gary L. Johanning, Phillip E. Cornwell, Douglas C. Heimburger and William E. Grizzle

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000701)89:1<171::AID-CNCR22>3.0.CO;2-O

      In this study, squamous cell carcinomas of the lung and larynx were shown to have significantly higher concentrations of ascorbic acid than matched uninvolved tissues. The accumulation of ascorbic acid by these cancerous tissues was shown to be associated with global methylation of DNA.

    22. Chemotherapy: Soft Tissue Sarcomas
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      The efficacy of a combination of etoposide, ifosfamide, and cisplatin in the treatment of patients with soft tissue sarcoma (pages 177–180)

      Zs. Pápai, Gy. Bodoky, J. Szántó, I. Poller, P. Rahóty, S. Eckhardt, I. Láng and M. Szendrői

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000701)89:1<177::AID-CNCR23>3.0.CO;2-3

      The combination of ifosfamide, etoposide, and cisplatin is promising in the treatment of patients with advanced soft tissue sarcoma, producing tolerable toxicity.

    23. Minorities: Cancer Survival
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      Cancer stage at diagnosis, treatment, and survival among American indians and non-American Indians in Montana (pages 181–186)

      Terry D. Dennis

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000701)89:1<181::AID-CNCR24>3.0.CO;2-H

      Survival from cancer in Montana American Indians was lower than in Montana non-American Indians even though the disease stage at diagnosis and the treatment received were similar in the two groups.

  3. Communication

    1. Top of page
    2. Commentary
    3. Original Articles
    4. Communication
    5. Correspondence
    1. General Topic

      International Union Against Cancer (UICC)
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      The UICC Telepathology Consultation Center : A global approach to improving consultation for pathologists in cancer diagnosis (pages 187–191)

      Manfred Dietel, Trong-Nghia Nguyen-Dobinsky and Peter Hufnagl

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000701)89:1<187::AID-CNCR25>3.0.CO;2-X

      Telepathology provides the tools for thorough and rapid cancer diagnosis as well as easy access to a “second opinion.” It is the global link for pathologists around the world.

    2. The Institute of Medical Informatics, Justus-Liebig-University of Giessen, Germany
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      Patterns of care for patients with primary differentiated carcinoma of the thyroid gland treated in Germany during 1996 (pages 192–201)

      Simon Hölzer, Christian Reiners, Klaus Mann, Michael Bamberg, Matthias Rothmund, Joachim Dudeck, Andrew K. Stewart, Scott A. Hundahl and for the U.S. and German Thyroid Cancer Group

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000701)89:1<192::AID-CNCR26>3.0.CO;2-7

      Demographic, risk factor, diagnostic, pathologic, and therapeutic information for a cohort of patients with thyroid carcinoma who were treated in Germany in 1996 are presented.

      See also pages 1–4 and 202–17.

    3. The American College of Surgeons Commission on Cancer and the American Cancer Society
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      Initial results from a prospective cohort study of 5583 cases of thyroid carcinoma treated in the United States during 1996 : An American College of Surgeons Commission on Cancer patient care evaluation study (pages 202–217)

      Scott A. Hundahl, Blake Cady, Myles P. Cunningham, Ernest Mazzaferri, Rosemary F. McKee, Juan Rosai, Jatin P. Shah, Amy M. Fremgen, Andrew K. Stewart, Simon Hölzer and for the U.S. and German Thyroid Cancer Study Group

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000701)89:1<202::AID-CNCR27>3.0.CO;2-A

      This report contains demographic, risk-factor, diagnostic, pathologic, and therapeutic information on a national cohort of patients with thyroid carcinoma treated in 1996. Complications of treatment are also discussed.

      See also pages 1–4 and 192–201.

  4. Correspondence

    1. Top of page
    2. Commentary
    3. Original Articles
    4. Communication
    5. Correspondence
    1. General Topic

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      A high number of tumor free axillary lymph nodes from patients with lymph node negative breast is associated with poor outcome (page 218)

      Hiram S. Cody III and Kimbery J. Van Zee

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000701)89:1<218::AID-CNCR28>3.0.CO;2-P

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      Author reply (pages 218–219)

      Robert L. Camp, Eric B. Rimm and David L. Rimm

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000701)89:1<218::AID-CNCR29>3.0.CO;2-M

    3. General Topic

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    4. You have free access to this content
      Author reply (pages 220–221)

      Michaela Bercovitch, Alexander Waller and Abraham Adunsky

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000701)89:1<220::AID-CNCR31>3.0.CO;2-V

    5. General Topic

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      Author reply (pages 222–223)

      Walter Fiedler, Ursula Gehling and Dieter K. Hossfeld

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000701)89:1<222::AID-CNCR33>3.0.CO;2-J

    7. General Topic

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      Author reply (pages 224–225)

      Irene Gage

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000701)89:1<224::AID-CNCR35>3.0.CO;2-7

    9. General Topic

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      Mandatory second opinion surgical pathology at a large referral hospital (pages 225–226)

      Ronald L. Sirota

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000701)89:1<225::AID-CNCR36>3.0.CO;2-1

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      Author reply (page 226)

      Joseph D. Kronz and Jonathan I. Epstein

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000701)89:1<226::AID-CNCR37>3.0.CO;2-W

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      Author reply (page 226)

      John E. Tomaszewski and Virginia A. LiVolsi

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000701)89:1<226::AID-CNCR38>3.0.CO;2-T

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      Acute myelogenous leukemia after exposure to strontium-89 for the treatment of adenocarcinoma of the prostate (pages 226–227)

      James S. Welsh and Steven P. Howard

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000701)89:1<226::AID-CNCR39>3.0.CO;2-Q

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      Author reply (page 227)

      Mark Weiss and Steven Kossman

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000701)89:1<227::AID-CNCR40>3.0.CO;2-C

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