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Original Article
Analysis of factors affecting the appearance of hepatocellular carcinoma in patients with chronic hepatitis C
A long term follow-up study after histologic diagnosis
Article first published online: 13 NOV 2000
DOI: 10.1002/1097-0142(20000701)89:1<53::AID-CNCR8>3.0.CO;2-6
Copyright © 2000 American Cancer Society
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Additional Information
How to Cite
Aizawa, Y., Shibamoto, Y., Takagi, I., Zeniya, M. and Toda, G. (2000), Analysis of factors affecting the appearance of hepatocellular carcinoma in patients with chronic hepatitis C. Cancer, 89: 53–59. doi: 10.1002/1097-0142(20000701)89:1<53::AID-CNCR8>3.0.CO;2-6
Publication History
- Issue published online: 13 NOV 2000
- Article first published online: 13 NOV 2000
- Manuscript Accepted: 14 MAR 2000
- Manuscript Revised: 17 FEB 2000
- Manuscript Received: 31 AUG 1999
- Abstract
- Article
- References
- Cited By
Keywords:
- hepatocellular carcinoma;
- chronic hepatitis C;
- liver biopsy;
- interferon
In patients with chronic hepatitis C, the annual incidence rate of hepatocellular carcinoma (HCC) was found to increase as the follow-up period progressed. The factors that independently affected the development of HCC were age, habitual heavy drinking, and histologic staging.
Abstract
BACKGROUND
Hepatocellular carcinoma (HCC) occurs more frequently in patients with hepatitis C virus (HCV)-related chronic liver disease than those with hepatitis B virus-related disease. It is important to assess the factors affecting the development of HCC.
METHODS
A long term follow-up study involving patients with chronic HCV was performed retrospectively. A total of 153 patients diagnosed between June 1981 and November 1990 with chronic HCV with or without cirrhosis by liver biopsy were enrolled in a long term follow-up study (average, 99.4 months) and the cumulative incidence rate of HCC and factors affecting the appearance of HCC were examined.
RESULTS
The 5-year cumulative incidence rate was 9%, the 10-year cumulative incidence rate was 23%, and the 15-year cumulative incidence rate was 42%. The annual rate of incidence increased as the follow-up period progressed. The authors selected ten variables and investigated their effect on the incidence rate of HCC, including age, gender, habitual heavy drinking, positivity of antibody against hepatitis B virus surface antigen, treatment with interferon (IFN) during the follow-up period, maximum and minimum serum alanine aminotransferase levels during the follow-up period, histologic staging, grading, and irregular regeneration of hepatocytes. Of the 10 variables, age (> 50 years), habitual heavy drinking, and histologic staging were determined to be independent risk factors according to multivariate Cox proportional hazards regression analysis. IFN therapy by itself was not found to be an independent factor affecting the appearance of HCC.
CONCLUSIONS
In patients with chronic HCV, the annual incidence rate of HCC appeared to increase as the follow-up period progressed. According to the results of the current study, the factors that independently affected the development of HCC were age, habitual heavy drinking, and histologic staging. Cancer 2000;89:53–9. © 2000 American Cancer Society.