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Cancer

Cover image for Cancer

15 September 2000

Volume 89, Issue 6

Pages 1181–1412

  1. Review Article

    1. Top of page
    2. Review Article
    3. Original Articles
    4. Erratum
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      Progress in antiangiogenic gene therapy of cancer (pages 1181–1194)

      Andrew L. Feldman and Steven K. Libutti

      Version of Record online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000915)89:6<1181::AID-CNCR1>3.0.CO;2-T

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      Although numerous endogenous inhibitors of angiogenesis have been identified as potential anticancer agents, limitations in their use as recombinant proteins have prompted investigators to develop gene therapy strategies to deliver these proteins. This review summarizes the current status of this rapidly expanding field.

  2. Original Articles

    1. Top of page
    2. Review Article
    3. Original Articles
    4. Erratum
    1. Anatomic Site

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      Stage as major long term outcome predictor in minor salivary gland carcinoma (pages 1195–1204)

      Vincent L. M. Vander Poorten, Alfonsus J. M. Balm, Frans J. M. Hilgers, I. Bing Tan, Ronald B. Keus and Augustinus A. M. Hart

      Version of Record online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000915)89:6<1195::AID-CNCR2>3.0.CO;2-J

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      Ten years after primary treatment of minor salivary gland carcinoma at a Dutch tertiary referral center, 60% of patients were free of tumor. Tumor stage was confirmed as the major determinant of overall survival, disease specific survival, and tumor recurrence after adequate therapy.

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      Dietary and familial determinants of 10-year survival among patients with gastric carcinoma (pages 1205–1213)

      Domenico Palli, Antonio Russo, Calogero Saieva, Simonetta Salvini, Andrea Amorosi and Adriano Decarli

      Version of Record online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000915)89:6<1205::AID-CNCR3>3.0.CO;2-5

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      A population-based series of 382 gastric carcinoma patients identified in a high risk area of Italy were interviewed on their dietary habits and were followed for 10 years. Alcohol intake was related negatively to overall survival (P = 0.02). In a subgroup of patients with a positive first-degree family history, survival was related to dietary intake with opposite effects for selected nutrients from animal and vegetable sources.

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      The cooperative role of p27 with cyclin E in the prognosis of advanced gastric carcinoma (pages 1214–1219)

      Che Xiangming, Shoji Natsugoe, Sonshin Takao, Shuichi Hokita, Gen Tanabe, Masamichi Baba, Kazunao Kuroshima and Takashi Aikou

      Version of Record online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000915)89:6<1214::AID-CNCR4>3.0.CO;2-0

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      The results of the current study indicate that reduced p27 expression is a negative prognostic factor for patients with cyclin E positive gastric carcinoma.

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      Loss of heterozygosity at 3p23 is correlated with poor survival in patients with colorectal carcinoma (pages 1220–1227)

      Pilar Iniesta, María-José Massa, Rosa González-Quevedo, Carmen de Juan, Alberto Morán, Andrés Sánchez-Pernaute, Javier Cerdán, Antonio Torres, Jose-Luis Balibrea and Manuel Benito

      Version of Record online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000915)89:6<1220::AID-CNCR5>3.0.CO;2-Z

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      In this work, the authors found that loss of heterozygosity at 3p23 constitutes a molecular abnormality that is related directly to a poor prognosis for patients with colorectal carcinoma.

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      Results of pharmacokinetic modulating chemotherapy in combination with hepatic arterial 5-fluorouracil infusion and oral UFT after resection of hepatic colorectal metastases (pages 1228–1235)

      Masato Kusunoki, Hidenori Yanagi, Masafumi Noda, Reigetsu Yoshikawa and Takehira Yamamura

      Version of Record online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000915)89:6<1228::AID-CNCR6>3.0.CO;2-O

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      Pharmacokinetic modulating chemotherapy (PMC) was designed as a uracil-related biochemical modulation of 5-fluorouracil. PMC drastically improved the prognosis after resection of hepatic colorectal metastasis.

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      Correlation between angiographically assessed vascularity and blood flow in hepatic metastases in patients with colorectal carcinoma (pages 1236–1244)

      Akihiro Yamaguchi, Hiroki Taniguchi, Satoshi Kunishima, Toshimori Koh and Hisakazu Yamagishi

      Version of Record online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000915)89:6<1236::AID-CNCR7>3.0.CO;2-K

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      Blood flow in hepatic metastases in patients with colorectal carcinoma is greater than is generally believed, because the blood flow in nontumorous liver parenchyma increases more than in parenchyma without metastasis.

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      Combination therapy with transcatheter arterial chemoembolization and percutaneous microwave coagulation therapy for hepatocellular carcinoma (pages 1245–1251)

      Toshihito Seki, Toru Tamai, Taiichi Nakagawa, Masato Imamura, Akira Nishimura, Noriyo Yamashiki, Kozo Ikeda and Kyoichi Inoue

      Version of Record online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000915)89:6<1245::AID-CNCR8>3.0.CO;2-F

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      Using a small number of microwave electrode insertions and microwave irradiations, percutaneous microwave coagulation therapy (PMCT) after transcatheter arterial chemoembolization can induce extensive necrosis in hepatocellular carcinomas measuring < 3.0 cm in greatest dimension. This combination therapy can enhance the efficacy of the PMCT and improve patient compliance.

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      Human pancreatic ribonuclease 1 : Expression and distribution in pancreatic adenocarcinoma (pages 1252–1258)

      Rosa Peracaula, Karen R. Cleary, Julia Lorenzo, Rafael de Llorens and Marsha L. Frazier

      Version of Record online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000915)89:6<1252::AID-CNCR9>3.0.CO;2-C

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      The authors report on the expression of ribonuclease 1 (RNase 1), a human pancreatic acinar protein, in tumor cells from ductal type pancreatic adenocarcinomas tissues. The expression of RNase 1 may account for the high levels of this protein detected in most serums from patients with pancreatic adenocarcinoma.

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      B7 costimulatory molecules from malignant cells in patients with B-cell chronic lymphoproliferative disorders trigger T-cell proliferation (pages 1259–1268)

      Livio Trentin, Alessandra Perin, Marta Siviero, Francesco Piazza, Monica Facco, Carmela Gurrieri, Silvia Galvan, Fausto Adami, Carlo Agostini, Giovanni Pizzolo, Renato Zambello and Gianpietro Semenzato

      Version of Record online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000915)89:6<1259::AID-CNCR10>3.0.CO;2-G

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      B7 molecules have been found to be expressed at resting conditions and to be upregulated upon CD40+ IL-4 in vitro activation on malignant B lymphocytes obtained from patients with B-cell chronic lymphoproliferative diseases. The evidence that these cells display an efficient antigen presentation suggests that vaccination with pulsed malignant B cells themselves or dendritic cells with in vitro preactivated tumor B cells might represent an alternative therapeutic approach in these patients to generate an antilymphoma T-cell response in vivo.

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      Time trends of cutaneous melanoma in Queensland, Australia and Central Europe (pages 1269–1278)

      Claus Garbe, G. Roderick C. McLeod and Petra G. Buettner

      Version of Record online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000915)89:6<1269::AID-CNCR11>3.0.CO;2-C

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      In both Central Europe (Germany, Austria, and Switzerland) and Queensland, Australia, trends toward thinner and less invasive melanomas were observed between 1986 and 1996, although the median tumor thickness decreased significantly only for Central European data. Health promotion activities concerning skin carcinoma should target men and elderly people, because those groups consistently were identified as presenting with more advanced melanomas.

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      Early localized peritoneal mesothelioma as an incidental finding at laparoscopy : Report of a case and implications regarding natural history of the disease (pages 1279–1284)

      Paul H. Sugarbaker, Hui Yan, Richard V. Grazi and Barry M. Shmookler

      Version of Record online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000915)89:6<1279::AID-CNCR12>3.0.CO;2-8

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      The features of an early localized peritoneal mesothelioma implicates the possibility of a uniform genetic defect in pelvic mesothelial cells. The patient responded to a combined cytoreductive surgery and intraperitoneal chemotherapy treatment regimen and remained free of disease at 24 months.

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      Serum CYFRA 21-1 is one of the most reliable tumor markers for breast carcinoma (pages 1285–1290)

      Bunzo Nakata, Yoshinari Ogawa, Tetsuro Ishikawa, Katsumi Ikeda, Yasuyuki Kato, Hiroji Nishino and Kosei Hirakawa

      Version of Record online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000915)89:6<1285::AID-CNCR13>3.0.CO;2-G

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      The sensitivity of serum CYFRA 21-1 in patients with both International Union Against Cancer (UICC) Stage IV and recurrent breast carcinoma was as high as CA 15-3, and the correlation between the two tumor markers was weak. The serum CYFRA 21-1 levels were found to be an independent prognostic factor for patients with breast carcinoma.

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      Histopathologic subtyping of cervical adenocarcinoma reveals increasing incidence rates of endometrioid tumors in all age groups : A population based study with review of all nonsquamous cervical carcinomas in Norway from 1966 to 1970, 1976 to 1980, and 1986 to 1990 (pages 1291–1299)

      G. Cecilie Alfsen, Steinar Ø. Thoresen, Gunnar B. Kristensen, Eva Skovlund and Vera M. Abeler

      Version of Record online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000915)89:6<1291::AID-CNCR14>3.0.CO;2-O

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      Adenocarcinoma of endometrioid histology has become the major subtype of cervical adenocarcinoma in Norway. The proportion of adenocarcinoma of endocervical type is reduced, with a decrease in incidence rate for women 55 years of age or older.

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      Differential expression of p53 and p21 in low grade cervical squamous intraepithelial lesions infected with low, intermediate, and high risk human papillomaviruses (pages 1300–1307)

      Athina Giannoudis and C. Simon Herrington

      Version of Record online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000915)89:6<1300::AID-CNCR15>3.0.CO;2-U

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      In this study, the authors demonstrate that low, intermediate, and high risk human papillomaviruses (HPVs) have different effects on p53 and p21 expression, and that the induction of numeric chromosomal abnormalities observed in low grade squamous intraepithelial cervical lesions by intermediate/high risk HPVs may be related to abnormal regulation of p53 expression.

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      Visual estimate of the percentage of carcinoma is an independent predictor of prostate carcinoma recurrence after radical prostatectomy (pages 1308–1314)

      Gustavo F. Carvalhal, Peter A. Humphrey, Phataraporn Thorson, Yan Yan, Christian G. Ramos and William J. Catalona

      Version of Record online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000915)89:6<1308::AID-CNCR16>3.0.CO;2-3

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      Determining the percentage of carcinoma by microscopic visual inspection of radical prostatectomy tissue sections is a simple and practical method for the measurement of tumor size in patients with prostate carcinoma. The percentage of carcinoma in tissue sections is an independent predictor of disease recurrence after surgery.

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      Cancer risk in families with hereditary prostate carcinoma : A possible link between prostate, breast, and gastric carcinoma (pages 1315–1321)

      Henrik Grönberg, Anders Bergh, Jan-Erik Damber and Monica Emanuelsson

      Version of Record online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000915)89:6<1315::AID-CNCR17>3.0.CO;2-8

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      In a study of Swedish families with hereditary prostate carcinoma, a significant excess of incidents of both breast carcinoma and gastric carcinoma was observed among first-degree relatives of men with prostate carcinoma.

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      Quality of life changes during conformal radiation therapy for prostate carcinoma (pages 1322–1328)

      Monika Janda, Natascha Gerstner, Andreas Obermair, Annerose Fuerst, Stefan Wachter, Karin Dieckmann and Richard Pötter

      Version of Record online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000915)89:6<1322::AID-CNCR18>3.0.CO;2-D

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      In patients with prostate carcinoma who were undergoing conformal external beam radiation therapy, fatigue and role functioning deteriorated temporarily during radiotherapy. Emotional functioning scales showed an improvement during the observation period.

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      Novel strategies and therapeutics for the treatment of prostate carcinoma (pages 1329–1348)

      Michael J. Morris and Howard I. Scher

      Version of Record online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000915)89:6<1329::AID-CNCR19>3.0.CO;2-Q

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      Efforts to define the biology of prostate carcinoma have led to the clinical development of novel treatment strategies beyond hormones and chemotherapy. However, the appropriate clinical application of these strategies and informative clinical trial designs have yet to be defined.

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      Bladder cancer : Race differences in extent of disease at diagnosis (pages 1349–1358)

      George R. Prout Jr., Margaret N. Wesley, Raymond S. Greenberg, Vivien W. Chen, Charles C. Brown, Alex W. Miller, Ronald S. Weinstein, Stanley J. Robboy, M. Alfred Haynes, Robert S. Blacklow and Brenda K. Edwards

      Version of Record online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000915)89:6<1349::AID-CNCR20>3.0.CO;2-D

      Older age group, higher grade, larger tumors, and presence of carcinoma in situ were related to greater extent of disease in blacks and whites. Studies of occupation and life style factors must be integrated with the use of biochemical and molecular methods to study the genetic factors involved.

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      A medical research council randomized trial in patients with primary cerebral non-Hodgkin lymphoma : Cerebral radiotherapy with and without cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy (pages 1359–1370)

      Graham M. Mead, Norman M. Bleehen, Anna Gregor, Jill Bullimore, D. Shirley Murrell, Roy P. Rampling, J. Trevor Roberts, Mark G. Glaser, Peter Lantos, James W. Ironside, Timothy H. Moss, Michael Brada, Jill B. Whaley and Sally P. Stenning

      Version of Record online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000915)89:6<1359::AID-CNCR21>3.0.CO;2-9

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      This randomized trial evaluated the impact on survival of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) chemotherapy after radiotherapy for patients with primary cerebral non-Hodgkin lymphoma. Although conclusions were limited by the size of the trial, no benefit of CHOP chemotherapy was found, and the data were sufficient to exclude a doubling of the median survival time through its use with a high degree of confidence.

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      Agreement rates among single photon emission computed tomography using gallium-67, computed axial tomography and lymphangiography for Hodgkin disease and correlation of image findings with clinical outcome (pages 1371–1379)

      Chul S. Ha, Jae-Gol Choe, Joseph S. Kong, Pamela K. Allen, Yoon K. Oh, James D. Cox and E. Edmund Kim

      Version of Record online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000915)89:6<1371::AID-CNCR22>3.0.CO;2-S

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      The agreement rates between gallium (Ga)-67 single photon emission computed tomography and computed tomography scans decrease especially in the mediastinum once chemotherapy is started. There is still a moderate risk of recurrence after loss of the gallium avidity after chemotherapy.

    22. General Topic

      Chemotherapy
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      Docetaxel-induced lymphopenia in patients with solid tumors : A prospective phenotypic analysis (pages 1380–1386)

      Athanasios Kotsakis, Evanthia Sarra, Maria Peraki, Michael Koukourakis, Stella Apostolaki, John Souglakos, Emmanuel Mavromanomakis, John Vlachonikolis and Vassilis Georgoulias

      Version of Record online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000915)89:6<1380::AID-CNCR23>3.0.CO;2-R

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      The administration of a single docetaxel dose (100 mg/m2 every 3 weeks) in patients with chemotherapy-naive solid tumors resulted in a significant decrease of the absolute number of peripheral blood, CD3+, CD4+, CD8+, and CD56+ but not of CD20+ lymphocytes. Subsequent chemotherapy courses resulted in further abnormalities of all lymphocyte subsets including CD20+ cells, whereas treatment discontinuation was followed by a recovery of CD3+ and CD4+ cells.

    23. Lymphoma, Extranodal
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      The prognostic significance of serum levels of soluble intercellular adhesion molecules-1 in patients with primary extranodal non-Hodgkin lymphomas (pages 1387–1395)

      Kenny I. K. Lei and Philip J. Johnson

      Version of Record online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000915)89:6<1387::AID-CNCR24>3.0.CO;2-3

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      Serum soluble intercellular adhesion molecule (sICAM)-1 levels are elevated in patients with extranodal lymphomas. In these individuals, high serum sICAM-1 levels are associated with B-symptoms, elevated lactate dehydrogenase level, advanced stage (Ann Arbor Staging System III/IV) disease, poor response to therapy, and inferior survival rates.

    24. Pediatric Oncology
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      Pleuropulmonary blastoma : Management and prognosis of 11 cases (pages 1396–1401)

      Paolo Indolfi, Fiorina Casale, Modesto Carli, Gianni Bisogno, Vito Ninfo, Giovanni Cecchetto, Serenella Bagnulo, Nicola Santoro, Maria Giuliano and Maria Teresa Di Tullio

      Version of Record online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000915)89:6<1396::AID-CNCR25>3.0.CO;2-2

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      Pleuropulmonary blastoma is a rare and highly aggressive pulmonary neoplasm in children. Despite the introduction of multimodal therapy, prognosis remains poor. The current study suggests that the best treatment is radical surgery, even in patients with microscopic residual disease. However, in the majority of patients initial surgery is incomplete because of massive tumor involvement. For this reason, neoadjuvant chemotherapy should be given to convert unresectable tumor in resectable disease.

    25. Quality of Life
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      Quality of life and mood in women receiving extensive chemotherapy for gynecologic cancer (pages 1402–1411)

      Susan K. Lutgendorf, Barrie Anderson, Nan Rothrock, Richard E. Buller, Anil K. Sood and Joel I. Sorosky

      Version of Record online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000915)89:6<1402::AID-CNCR26>3.0.CO;2-H

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      Quality of life and mood were investigated among women who had received intensive chemotherapy for at least 1 year for advanced gynecologic cancers. This study indicated that extensively treated gynecologic oncology patients experienced substantial decrements to quality of life, and yet treatment still was considered worthwhile by a majority of patients.

  3. Erratum

    1. Top of page
    2. Review Article
    3. Original Articles
    4. Erratum
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      Erratum (page 1412)

      Version of Record online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20000915)89:6<1412::AID-CNCR27>3.0.CO;2-D

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