The prognostic significance of p16INK4a/p14ARF locus deletion and MDM-2 protein expression in adult acute myelogenous leukemia (pages 1976–1982)
Stefan Faderl, Hagop M. Kantarjian, Elihu Estey, Taghi Manshouri, Ching-Yang Chan, Abdel Rahman Elsaied, Steven M. Kornblau, Jorge Cortes, Deborah A. Thomas, Sherry Pierce, Michael J. Keating, Zeev Estrov and Maher Albitar
Version of Record online: 30 OCT 2000 | DOI: 10.1002/1097-0142(20001101)89:9<1976::AID-CNCR14>3.0.CO;2-N
Deletions of p16/p14 and p15 are infrequent in acute myeloid leukemia (AML) but confer a poor prognosis when present. Overexpression of MDM-2 is common in AML, is associated with shorter event free survival, and may be due to other mechanisms than deletion of p14.