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Cancer

Cover image for Cancer

1 November 2000

Volume 89, Issue 9

Pages 1869–2024

  1. Original Articles

    1. Top of page
    2. Original Articles
    1. Anatomic Site

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      Localization of initial lymph node metastasis from carcinoma of the thoracic esophagus (pages 1869–1873)

      Toshiki Matsubara, Mamoru Ueda, Shouichi Kaisaki, Junko Kuroda, Chiaki Uchida, Norihiro Kokudo, Takashi Takahashi, Toshifusa Nakajima and Akio Yanagisawa

      Version of Record online: 30 OCT 2000 | DOI: 10.1002/1097-0142(20001101)89:9<1869::AID-CNCR1>3.0.CO;2-N

      In esophageal carcinoma, solitary lymph node involvement was not rare and was commonly located in lymph nodes that are accessible without thoracotomy. Esophagectomy with systematic dissection offered a favorable outcome.

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      Frequency and clinical impact of lymph node micrometastasis and tumor cell microinvolvement in patients with adenocarcinoma of the esophagogastric junction (pages 1874–1882)

      James D. Mueller, Hubert J. Stein, Tao Oyang, Shoji Natsugoe, Marcus Feith, Martin Werner and J. Rüdiger Siewert

      Version of Record online: 30 OCT 2000 | DOI: 10.1002/1097-0142(20001101)89:9<1874::AID-CNCR2>3.0.CO;2-M

      In patients with tumors of esophagogastric junction, immunohistochemistry for cytokeratins finds that tumor cell involvement is not infrequent in regional lymph nodes that have been classified by routine methods to be free of tumor. There are important differences in the pattern and impact of microscopic lymph node tumor involvement between distal esophageal tumors and cardia or subcardia tumors.

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      Asian patients with gastric carcinoma in the United States exhibit unique clinical features and superior overall and cancer specific survival rates (pages 1883–1892)

      Charles P. Theuer, Tom Kurosaki, Argyrios Ziogas, John Butler and Hoda Anton-Culver

      Version of Record online: 30 OCT 2000 | DOI: 10.1002/1097-0142(20001101)89:9<1883::AID-CNCR3>3.0.CO;2-H

      Asian patients with gastric carcinoma in the United States have superior overall and cancer specific survival rates by multivariate analysis and are more likely to present with localized (lymph node negative) disease.

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      Low dose fractionated radiation enhances the radiosensitization effect of paclitaxel in colorectal tumor cells with mutant p53 (pages 1893–1900)

      Damodaran Chendil, Rachael Oakes, Rachael A. Alcock, Nish Patel, Christopher Mayhew, Mohammed Mohiuddin, Vincent S. Gallicchio and Mansoor M. Ahmed

      Version of Record online: 30 OCT 2000 | DOI: 10.1002/1097-0142(20001101)89:9<1893::AID-CNCR4>3.0.CO;2-B

      The current study was undertaken to investigate the influence of wild-type or mutant p53 status on the radiosensitizing effect of paclitaxel in colorectal tumor cell lines. The results of this study indicate that there is likely to be minimal benefit from paclitaxel combined with radiation in the treatment of tumors with mutant p53. However, fractionated low dose radiation (multiple small fractions per day) may render an enhanced radiosensitization effect and in the current study was found to overcome the radiation resistance caused by mutant p53 status in colorectal tumors.

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      Classification of advanced colorectal carcinomas by tumor edge morphology : Evidence for different pathogenesis and significance of polypoid and nonpolypoid tumors (pages 1901–1909)

      Susannah M. C. George, Markus J. Mäkinen, Petra Jernvall, Jyrki Mäkelä, Pirkko Vihko and Tuomo J. Karttunen

      Version of Record online: 30 OCT 2000 | DOI: 10.1002/1097-0142(20001101)89:9<1901::AID-CNCR5>3.0.CO;2-#

      Evaluation of tumor edge morphology gives clues to the pathogenetic pathway of colorectal carcinoma and suggests that a significant proportion of cancers are developed through nonpolypoid pathway. Tumor edge morphology has prognostic significance because nonpolypoid tumors show increased risk of recurrence.

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      Enhanced expression and activation of Ca2+/calmodulin-dependent protein kinase IV in hepatocellular carcinoma (pages 1910–1916)

      Nobuaki Tamura, Yuji Tai, Katsuyoshi Sugimoto, Ryoji Kobayashi, Ryoji Konishi, Mikio Nishioka, Tsutomu Masaki, Shunichiro Nagahata and Masaaki Tokuda

      Version of Record online: 30 OCT 2000 | DOI: 10.1002/1097-0142(20001101)89:9<1910::AID-CNCR6>3.0.CO;2-V

      Ca2+/calmodulin-dependent protein kinase IV is expressed in cancerous hepatocytes and may be involved in the carcinogenesis of hepatocellular carcinoma.

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      Cost analysis of pancreatic carcinoma treatment (pages 1917–1924)

      Wei Du, Daniel Touchette, Vainutis K. Vaitkevicius, William P. Peters and Anthony F. Shields

      Version of Record online: 30 OCT 2000 | DOI: 10.1002/1097-0142(20001101)89:9<1917::AID-CNCR7>3.0.CO;2-L

      The total treatment costs of 103 patients with pancreatic carcinoma who were treated at the Karmanos Cancer Institute were calculated and correlated with patient demographics, clinical characteristics, and treatment information to determine the factors that significantly drive the costs of pancreatic carcinoma treatment.

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      Combined therapy with conservative surgery, radiotherapy, and regional chemotherapy for maxillary sinus carcinoma (pages 1925–1932)

      Hiroshi Nishino, Mamoru Miyata, Mamoru Morita, Kazuhiro Ishikawa, Takeharu Kanazawa and Keiichi Ichimura

      Version of Record online: 30 OCT 2000 | DOI: 10.1002/1097-0142(20001101)89:9<1925::AID-CNCR8>3.0.CO;2-H

      In patients with carcinoma of the maxillary sinus, control of the primary tumor site is an important goal of curative treatment. In this study the authors examined the use of combined therapy with conservative surgery, radiotherapy, and regional chemotherapy as an effective method for achieving local control and the preservation of ocular function.

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      Association of allelic imbalance at locus D13S171 (BRCA2) and p53 alterations with tumor kinetics and chromosomal instability (aneuploidy) in nonsmall cell lung carcinoma (pages 1933–1945)

      V. G. Gorgoulis, A. Kotsinas, P. Zacharatos, G. Mariatos, T. Liloglou, E. Tsoli, S. Kokotas, C. Fassoulas, J. K. Field and Ch. Kittas

      Version of Record online: 30 OCT 2000 | DOI: 10.1002/1097-0142(20001101)89:9<1933::AID-CNCR9>3.0.CO;2-D

      Loss of heterozygosity (LOH) at D13S171 locus (BRCA2) is a frequent event in nonsmall cell lung carcinomas (NSCLCs). However, tumor kinetic parameters (proliferation and apoptotic indices) and ploidy status in BRCA2 (LOH) NSCLCs are highly dependent on p53 status.

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      High dose radiation therapy and chemotherapy as induction treatment for Stage III nonsmall cell lung carcinoma (pages 1946–1952)

      Sujay A. Vora, Benedict D. T. Daly, Lawrence Blaszkowsky, John J. McGrath, Mark Bankoff, Stacy Supran and Thomas A. Dipetrillo

      Version of Record online: 30 OCT 2000 | DOI: 10.1002/1097-0142(20001101)89:9<1946::AID-CNCR10>3.0.CO;2-1

      Preoperative chemoradiation using higher radiation doses is feasible with acceptable toxicity. The results of the current study found that increased local control, a higher complete pathologic response rate, and increased overall survival rate occurred in patients treated in this study compared with prior studies.

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      Similar outcome of elderly patients in Intergroup Trial 0096 : Cisplatin, etoposide, and thoracic radiotherapy administered once or twice daily in limited stage small cell lung carcinoma (pages 1953–1960)

      Alan R. Yuen, Guangyong Zou, Andrew T. Turrisi, William Sause, Ritsuko Komaki, Henry Wagner, Seena C. Aisner, Robert B. Livingston, Ronald Blum and David H. Johnson

      Version of Record online: 30 OCT 2000 | DOI: 10.1002/1097-0142(20001101)89:9<1953::AID-CNCR11>3.0.CO;2-6

      Elderly patients (70 years or older) with limited stage small cell lung carcinoma had a similar response and survival rate compared with those younger than 70 years. However, toxicity, particularly hematologic, was greater among the elderly, suggesting that selected older patients should be considered for optimum treatment approaches.

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      Reproductive functions in female patients treated with adjuvant and neoadjuvant chemotherapy for localized osteosarcoma of the extremity (pages 1961–1965)

      Alessandra Longhi, Eleonora Porcu, Simone Petracchi, Michela Versari, Lucia Conticini and Gaetano Bacci

      Version of Record online: 30 OCT 2000 | DOI: 10.1002/1097-0142(20001101)89:9<1961::AID-CNCR12>3.0.CO;2-8

      The authors assessed the effects of different chemotherapy protocols (3 or 4 drugs: MTX, ADM, CDP ± IFO) on reproductive function in 92 female osteosarcoma patients treated over a 20-year period with a median follow-up of 9.6 years. Only two patients had early menopause due to chemotherapy. The fecundity rate was close to the age-corrected normal population. No congenital anomalies were observed in the 19 newborns.

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      Mechanism for bone invasion of oral cancer cells mediated by interleukin-6 in vitro and in vivo (pages 1966–1975)

      Masato Okamoto, Kenji Hiura, Go Ohe, Yasuo Ohba, Kunihoro Terai, Tetsuya Oshikawa, Sachiko Furuichi, Hidetomo Nishikawa, Keiji Moriyama, Hideo Yoshida and Mitsunobu Sato

      Version of Record online: 30 OCT 2000 | DOI: 10.1002/1097-0142(20001101)89:9<1966::AID-CNCR13>3.0.CO;2-R

      Cancer-derived interleukin-6 plays a significant role in the bone invasion of oral cancer cells at least in part by its stimulatory effect for osteoclastic bone resorption as well as for cancer cell migration into the bone that has been resorbed.

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      The prognostic significance of p16INK4a/p14ARF locus deletion and MDM-2 protein expression in adult acute myelogenous leukemia (pages 1976–1982)

      Stefan Faderl, Hagop M. Kantarjian, Elihu Estey, Taghi Manshouri, Ching-Yang Chan, Abdel Rahman Elsaied, Steven M. Kornblau, Jorge Cortes, Deborah A. Thomas, Sherry Pierce, Michael J. Keating, Zeev Estrov and Maher Albitar

      Version of Record online: 30 OCT 2000 | DOI: 10.1002/1097-0142(20001101)89:9<1976::AID-CNCR14>3.0.CO;2-N

      Deletions of p16/p14 and p15 are infrequent in acute myeloid leukemia (AML) but confer a poor prognosis when present. Overexpression of MDM-2 is common in AML, is associated with shorter event free survival, and may be due to other mechanisms than deletion of p14.

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      Surgical therapy for distant metastases of malignant melanoma (pages 1983–1991)

      Thomas Meyer, Susanne Merkel, Jonas Goehl and Werner Hohenberger

      Version of Record online: 30 OCT 2000 | DOI: 10.1002/1097-0142(20001101)89:9<1983::AID-CNCR15>3.0.CO;2-S

      Curative resection improves the prognoses of patients who have distant melanoma metastases. In individual cases, even long term survival can be achieved.

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      A reverse transcriptase-polymerase chain reaction assay in the diagnosis of soft tissue sarcomas (pages 1992–1998)

      Noriko Naito, Akira Kawai, Mamoru Ouchida, Tomoyuki Dan'ura, Yuki Morimoto, Toshifumi Ozaki, Kenji Shimizu and Hajime Inoue

      Version of Record online: 30 OCT 2000 | DOI: 10.1002/1097-0142(20001101)89:9<1992::AID-CNCR16>3.0.CO;2-R

      There was a strong concordance between molecular diagnostic assay using reverse transcriptase-polymerase chain reaction (RT-PCR) for detecting a specific fusion transcript and standard histopathologic diagnosis in adult patients with soft tissue sarcomas. The authors believe the RT-PCR assay for detecting a specific fusion transcript will be a useful objective tool with which to confirm the diagnosis of adult soft tissue sarcomas.

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      Breast carcinoma after cancer at another site : Method of detection, tumor characteristics, and surgical treatment (pages 1999–2005)

      Mary J. Nissen, DeAnn Lazovich and Gail Jolitz

      Version of Record online: 30 OCT 2000 | DOI: 10.1002/1097-0142(20001101)89:9<1999::AID-CNCR17>3.0.CO;2-3

      Clinical characteristics of breast carcinoma after cancer at another site were by and large similar to those of first primary breast carcinoma. The more favorable prognostic characteristics among women with a history of cancer were accounted for by increased medical surveillance.

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      The prognostic significance of p53 tumor suppressor gene alterations in ovarian carcinoma (pages 2006–2017)

      Mark S. Shahin, Jonathon H. Hughes, Anil K. Sood and Richard E. Buller

      Version of Record online: 30 OCT 2000 | DOI: 10.1002/1097-0142(20001101)89:9<2006::AID-CNCR18>3.0.CO;2-7

      Functionally null p53 conveys a worsened overall survival rate in ovarian carcinoma, which holds true in a multivariate analysis of advanced stage disease. This group of patients should be targeted for more novel therapeutic strategies such as p53 gene replacement.

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      Increasing levels of hypoxia in prostate carcinoma correlate significantly with increasing clinical stage and patient age : An Eppendorf pO2 study (pages 2018–2024)

      B. Movsas, J. D. Chapman, R. E. Greenberg, A. L. Hanlon, E. M. Horwitz, W. H. Pinover, C. Stobbe and G. E. Hanks

      Version of Record online: 30 OCT 2000 | DOI: 10.1002/1097-0142(20001101)89:9<2018::AID-CNCR19>3.0.CO;2-Y

      This study, employing the Eppendorf pO2 microelectrode, suggests that hypoxia exists in the tumors of patients with prostate carcinoma. Among the brachytherapy (spinal anesthesia) patients, increasing levels of hypoxia (within prostatic tissue) correlated significantly with increasing clicical stage and patient age.

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