Celia Byrne, James L. Connolly, Graham A. Colditz and Stuart J. Schnitt
Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20001115)89:10<2046::AID-CNCR3>3.0.CO;2-F
A case–control study, nested within the prospective Nurses' Health Study, indicated that women who had proliferative benign breast disease, with or without atypia, were at moderately to substantially increased risk of developing postmenopausal breast carcinoma compared with women who had nonproliferative benign conditions. In general, postmenopausal use of exogenous female hormones did not increase breast carcinoma risk for women who had proliferative benign breast disease. However, the analysis did not exclude the possibility of an association among particular hormone combinations, dosages, and increased risk.