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Cancer

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15 November 2000

Volume 89, Issue 10

Pages 2025–2144

  1. Original Articles

    1. Top of page
    2. Original Articles
    3. Errata
    1. Anatomic Site

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      Sporadic colorectal adenocarcinomas with high-frequency microsatellite instability : Pathobiologic features, hMLH1 and hMSH2 expression, and clinical outcome (pages 2025–2037)

      Roberta Gafà, Iva Maestri, Maurizio Matteuzzi, Alessandra Santini, Stefano Ferretti, Luigi Cavazzini and Giovanni Lanza

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20001115)89:10<2025::AID-CNCR1>3.0.CO;2-S

      High-frequency microsatellite instability occurs in a subset of sporadic large bowel adenocarcinomas that display distinct clinical, pathologic, and biologic features.

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      Host defense and survival in patients with lung carcinoma : Prognostic significance of immunomorphologic changes in regional lymph nodes and lymphocytic infiltration of primary tumor (pages 2038–2045)

      Angelo Di Giorgio, Pietro Mingazzini, Paolo Sammartino, Ambra Canavese, Paolo Arnone and Massimo Scarpini

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20001115)89:10<2038::AID-CNCR2>3.0.CO;2-J

      Immune responses in locoregional lymph nodes and at primary tumor sites are prognostic variables that influence long term survival after curative resection for lung carcinoma and may help in stratifying patients for clinical trials of postoperative adjuvant therapy, including immune treatments.

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      Biopsy confirmed benign breast disease, postmenopausal use of exogenous female hormones, and breast carcinoma risk (pages 2046–2052)

      Celia Byrne, James L. Connolly, Graham A. Colditz and Stuart J. Schnitt

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20001115)89:10<2046::AID-CNCR3>3.0.CO;2-F

      A case–control study, nested within the prospective Nurses' Health Study, indicated that women who had proliferative benign breast disease, with or without atypia, were at moderately to substantially increased risk of developing postmenopausal breast carcinoma compared with women who had nonproliferative benign conditions. In general, postmenopausal use of exogenous female hormones did not increase breast carcinoma risk for women who had proliferative benign breast disease. However, the analysis did not exclude the possibility of an association among particular hormone combinations, dosages, and increased risk.

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      Cadherin expression in glandular tumors of the cervix : Aberrant P-cadherin expression as a possible marker of malignancy (pages 2053–2058)

      Aaron C. Han, Mitchell I. Edelson, Alejandro Peralta Soler, Karen A. Knudsen, Beatriz Lifschitz-Mercer, Bernard Czernobilsky, Norman G. Rosenblum and Hernando Salazar

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20001115)89:10<2053::AID-CNCR4>3.0.CO;2-C

      The authors examined the expression of E-cadherin and P-cadherin in glandular tumors of the cervix and found that P-cadherin is aberrantly expressed in neoplastic glands and may be a marker of malignancy.

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      Expression of c-Ets1 is associated with malignant potential in endometrial carcinoma (pages 2059–2067)

      Noriyuki Takai, Tami Miyazaki, Kayo Fujisawa, Kaei Nasu and Isao Miyakawa

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20001115)89:10<2059::AID-CNCR5>3.0.CO;2-3

      The protooncogene c-ets1 is a transcriptional factor that controls the expression of a number of genes involved in extracellular matrix remodeling. The authors' results show that c-Ets1 expression in endometrial carcinoma is associated with the malignant potential of this tumor.

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      Ovarian carcinoma diagnosis : Results of a national ovarian cancer survey (pages 2068–2075)

      Barbara A. Goff, Lynn Mandel, Howard G. Muntz and Cindy H. Melancon

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20001115)89:10<2068::AID-CNCR6>3.0.CO;2-Z

      Most women with ovarian carcinoma have symptoms before diagnosis and frequently experience delays in diagnosis.

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      Carcinoma of the fallopian tube : Clinicopathologic study of 151 patients treated at the Norwegian Radium Hospital (pages 2076–2084)

      Mark Baekelandt, Anne Jorunn Nesbakken, Gunnar B. Kristensen, Claes G. Tropé and Vera M. Abeler

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20001115)89:10<2076::AID-CNCR7>3.0.CO;2-V

      Whereas there seems to be a high degree of similarity in biologic behavior and prognostic factors among patients with advanced fallopian tube carcinoma and advanced ovarian carcinoma, important differences are found in patients with Stage I disease.

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      Prostatourethral-rectal fistula after prostate brachytherapy : Incidence and risk factors (pages 2085–2091)

      Dan Theodorescu, Jay Y. Gillenwater and Panos G. Koutrouvelis

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20001115)89:10<2085::AID-CNCR8>3.0.CO;2-Q

      In a large series of patients with localized prostate carcinoma who were treated with brachytherapy, the authors document the incidence and risk factors associated with the development of prostatourethral-rectal fistula, the most serious complication associated with this technique. The data suggest that the overall incidence of this complication is very low and that overall radiation dose delivered and biopsy of the anterior rectal wall are significant risk factors. The latter observation has not been documented previously, and recognition may reduce the incidence of iatrogenic fistula formation in the future.

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      Implication of telomerase activity and alternations of telomere length in the histologic characteristics of intracranial meningiomas (pages 2092–2098)

      Han-Jung Chen, Cheng-Loong Liang, Kang Lu, Jui-Wei Lin and Chung-Lung Cho

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20001115)89:10<2092::AID-CNCR9>3.0.CO;2-N

      High detection rate of telomerase activity and elongated telomere length was found in atypical or malignant meningiomas. They are useful predictors for prognosis of patients with meningiomas.

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      A combination therapy of continuous superselective intraarterial carboplatin infusion and radiation therapy for locally advanced head and neck carcinoma : A Phase I study (pages 2099–2105)

      Nobukazu Fuwa, Yoshiyuki Ito, Akira Matsumoto, Minoru Kamata, Takesi Kodaira, Kazuhisa Furutani, Masahiro Sasaoka, Yasuo Kimura and Kozo Morita

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20001115)89:10<2099::AID-CNCR10>3.0.CO;2-4

      Superselective intraarterial carboplatin infusion and radiation therapy have important applications for carcinoma of the tongue and base of the tongue.

    11. General Topic

      Lymphoma, Extranodal
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      Clinicopathologic and genotypic study of extranodal nasal-type natural killer/T-cell lymphoma and natural killer precursor lymphoma among Koreans (pages 2106–2116)

      Y. H. Ko, H. J. Ree, W. S. Kim, W. H. Choi, W. S. Moon and S. W. Kim

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20001115)89:10<2106::AID-CNCR11>3.0.CO;2-G

      Most nasal-type upper aerodigestive natural killer (NK)/T-cell lymphomas among Koreans are genotypically of NK derivation, and few belong to T lineage. However, both tumors appear to share common histologic, immunophenotypic, and clinical features, and presence or absence of Epstein–Barr virus in these lymphomas has no significant influence on the histologic changes.

    12. Pediatric Oncology
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      Successful treatment of metastatic retinoblastoma (pages 2117–2121)

      Ira J. Dunkel, Alexander Aledo, Nancy A. Kernan, Brian Kushner, Lisa Bayer, Smitha V. Gollamudi, Jonathan L. Finlay and David H. Abramson

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20001115)89:10<2117::AID-CNCR12>3.0.CO;2-9

      Four consecutive children with metastatic retinoblastoma achieved long term event free survival with intensive chemotherapy and radiation therapy.

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      Granulocyte-colony stimulating factor and multiple cycles of strongly myelosuppressive alkylator-based combination chemotherapy in children with neuroblastoma (pages 2122–2130)

      Brian H. Kushner, Glenn Heller, Kim Kramer and Nai-Kong V. Cheung

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20001115)89:10<2122::AID-CNCR13>3.0.CO;2-K

      Prophylactic use of granulocyte-colony stimulating factor (G-CSF) with multiple cycles of strongly myelosuppressive alkylator-based combination chemotherapy hastened absolute neutrophil count recovery but did not reduce the incidence of febrile episodes, had little impact on infection rates, did not yield augmented dose intensity, and was associated with prolonged thrombocytopenia in late cycles. The data support more limited use of G-CSF in this clinical setting.

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      Oral trofosfamide and etoposide in pediatric patients with glioblastoma multiforme (pages 2131–2137)

      Johannes E. A. Wolff, Gabriele Mölenkamp, Silke Westphal, Thorsten Pietsch, Astrid Gnekow, Rolf-Dieter Kortmann and Joachim Kuehl

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20001115)89:10<2131::AID-CNCR14>3.0.CO;2-J

      The combination of oral trofosfamide with etoposide was well tolerated but did not increase survival of pediatric patients with glioblastoma multiforme.

    15. T-Cell Lymphoproliferative Disease
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      Lymphomatoid papulosis associated with both severe hypereosinophilic syndrome and CD30 positive large T-cell lymphoma : A case report (pages 2138–2143)

      Brigitte Granel, Jacques Serratrice, Laure Swiader, Nicole Horshowski, Didier Blaise, Norbert Vey, Dominique Metras, Gilbert Habib, Patrick Disdier and Pierre-Jean Weiller

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20001115)89:10<2138::AID-CNCR15>3.0.CO;2-W

      The authors report an unusual case of T-cell lymphoma occurring in a patient with lymphomatoid papulosis and severe hypereosinophilic syndrome.

  2. Errata

    1. Top of page
    2. Original Articles
    3. Errata
    1. You have free access to this content
      Errata (page 2144)

      Article first published online: 13 NOV 2000 | DOI: 10.1002/1097-0142(20001115)89:10<2144::AID-CNCR16>3.0.CO;2-3

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