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Original Article
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The early identification of lung carcinoma by sputum cytology
Article first published online: 7 DEC 2000
DOI: 10.1002/1097-0142(20001201)89:11+<2461::AID-CNCR23>3.0.CO;2-L
Copyright © 2000 American Cancer Society
Issue
1097-0142/asset/cover.gif?v=1&s=a7299bc18f075294c232ade468773cd0672bd470 "Cancer")
Cancer
Supplement: Prevention and Early Diagnosis of Lung Cancer
Volume 89, Issue Supplement 11, pages 2461–2464, 1 December 2000
Additional Information
How to Cite
Petty, T. L. (2000), The early identification of lung carcinoma by sputum cytology. Cancer, 89: 2461–2464. doi: 10.1002/1097-0142(20001201)89:11+<2461::AID-CNCR23>3.0.CO;2-L
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fax: 303-832-5137
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As a speaker and consultant, Dr. Petty has financial interests in Boehringer-Ingleheim, Glaxo, Pfizer, and Medtrac.
Publication History
- Issue published online: 7 DEC 2000
- Article first published online: 7 DEC 2000
- Manuscript Received: 19 JUN 2000
- Manuscript Accepted: 19 JUN 2000
- Abstract
- Article
- References
- Cited By
Keywords:
- sputum;
- cytology;
- lung carcinoma;
- identification
Abstract
BACKGROUND
Sputum cytology was considered to be ineffective in previous National Cancer Institute trials for early lung carcinoma detection. However, sputum cytology was effective in identifying roentgenographically occult lung carcinoma in a community lung carcinoma identification program, where lung carcinoma was suspected on the basis of symptoms, smoking, or airflow obstruction.
METHODS
The community project and the results of a newer lung carcinoma identification program were reviewed.
RESULTS
Actuarial survival curves from a previously published study where 46 of 51 roentgenographically occult carcinomas could be treated by surgery (n = 27) or curative radiation therapy (n = 19) is presented. Overall survival, taking deaths from all causes at five years, was 54.4%. The serial study of high risk patients with airflow obstruction and more than 30 pack-years of smoking revealed a 1.8% yield of lung carcinoma. This is a higher yield than in mammography (0.3%–0.5%).
CONCLUSION
Sputum cytology can be useful in identifying lung carcinoma in its early and occult stages, particularly in patients at high risk for this disease. Cancer 2000;89:2461–4. © 2000 American Cancer Society.