The early identification of lung carcinoma by sputum cytology
Article first published online: 7 DEC 2000
Copyright © 2000 American Cancer Society
Supplement: Prevention and Early Diagnosis of Lung Cancer
Volume 89, Issue Supplement 11, pages 2461–2464, 1 December 2000
How to Cite
Petty, T. L. (2000), The early identification of lung carcinoma by sputum cytology. Cancer, 89: 2461–2464. doi: 10.1002/1097-0142(20001201)89:11+<2461::AID-CNCR23>3.0.CO;2-L
As a speaker and consultant, Dr. Petty has financial interests in Boehringer-Ingleheim, Glaxo, Pfizer, and Medtrac.
- Issue published online: 7 DEC 2000
- Article first published online: 7 DEC 2000
- Manuscript Received: 19 JUN 2000
- Manuscript Accepted: 19 JUN 2000
- lung carcinoma;
Sputum cytology was considered to be ineffective in previous National Cancer Institute trials for early lung carcinoma detection. However, sputum cytology was effective in identifying roentgenographically occult lung carcinoma in a community lung carcinoma identification program, where lung carcinoma was suspected on the basis of symptoms, smoking, or airflow obstruction.
The community project and the results of a newer lung carcinoma identification program were reviewed.
Actuarial survival curves from a previously published study where 46 of 51 roentgenographically occult carcinomas could be treated by surgery (n = 27) or curative radiation therapy (n = 19) is presented. Overall survival, taking deaths from all causes at five years, was 54.4%. The serial study of high risk patients with airflow obstruction and more than 30 pack-years of smoking revealed a 1.8% yield of lung carcinoma. This is a higher yield than in mammography (0.3%–0.5%).
Sputum cytology can be useful in identifying lung carcinoma in its early and occult stages, particularly in patients at high risk for this disease. Cancer 2000;89:2461–4. © 2000 American Cancer Society.