Reduction in fat intake is not associated with weight loss in most women after breast cancer diagnosis
Evidence from a randomized controlled trial †
Version of Record online: 4 JAN 2001
Copyright © 2001 American Cancer Society
Volume 91, Issue 1, pages 25–34, 1 January 2001
How to Cite
Rock, C. L., Thomson, C., Caan, B. J., Flatt, S. W., Newman, V., Ritenbaugh, C., Marshall, J. R., Hollenbach, K. A., Stefanick, M. L. and Pierce, J. P. (2001), Reduction in fat intake is not associated with weight loss in most women after breast cancer diagnosis. Cancer, 91: 25–34. doi: 10.1002/1097-0142(20010101)91:1<25::AID-CNCR4>3.0.CO;2-G
Other authors and researchers for the Women”s Healthy Eating and Living (WHEL) Study Group: WHEL Study Coordinating Center: University of California at San Diego, Cancer Prevention and Control Program, La Jolla, CA: John P. Pierce, Ph.D. (Principal Investigator); Cheryl L. Rock, Ph.D., R.D.; Vicky E. Jones, M.D.; Susan Faerber, B.A.; Vicky Newman, M.S., R.D.; Shirley W. Flatt, M.S.; Sheila Kealey, M.P.H.; Elizabeth Gilpin, M.S., Linda Wasserman, M.D., Ph.D. WHEL Study Clinical Sites: Kaiser Permanente Northern California, Oakland, CA: Bette J. Caan, Dr.P.H.; Lou Ferenbacher, M.D.; Northern California Cancer Center, Union City, CA: Marcia L. Stefanick, Ph.D.; Robert Carlson, M.D.; University of Arizona, Tucson & Phoenix, AZ: James R. Marshall, Ph.D.; Cynthia Thomson, Ph.D., R.D.; James Warnecke, M.D.; University of California at Davis, Davis, CA: Mary N. Haan, Dr.P.H.; Sidney Scudder, M.D.; University of California at San Diego, Cancer Center, La Jolla, CA: Vicky E. Jones, M.D.; Kathryn A. Hollenbach, Ph.D.; University of Texas M. D. Anderson Cancer Center, Houston, TX: Lovell A. Jones, Ph.D.; Richard Theriault, D.O.; Center for Health Research Portland, Portland, OR: Cheryl Ritenbaugh, Ph.D., Mark Rarick, M.D.
- Issue online: 4 JAN 2001
- Version of Record online: 4 JAN 2001
- Manuscript Revised: 28 AUG 2000
- Manuscript Accepted: 28 AUG 2000
- Manuscript Received: 6 APR 2000
- Walton Family Foundation
- NCI. Grant Number: CA69375
- General Clinical Research Center
- NIH. Grant Numbers: M01-RR00070, M01-RR00827
- weight loss;
- breast cancer;
- dietary fat;
- dietary fiber
A reduction in dietary fat intake has been suggested as a method to promote weight loss in women at risk for breast cancer recurrence.
Weight change in response to diet intervention was examined in 1010 women who had completed treatment for Stage I, Stage II, or Stage IIIA (American Joint Committee on Cancer staging system) primary operable breast cancer during their first year of participation in a randomized, controlled, diet intervention trial to reduce risk of recurrence. Diet intervention was performed by telephone counseling and promoted a low fat diet that also was high in fiber, vegetables, and fruit. The comparison group was provided with general dietary guidelines to reduce disease risk. Multiple linear regression models were used to examine the relations among demographic and personal characteristics, changes in diet composition and exercise level, and change in body weight or body mass index.
The average weight change in the 1-year period was 0.04 kg for the intervention group and 0.46 kg for the comparison group. For the total group, body weight was stable (± 5% baseline weight) for 743 women (74%), whereas 114 (11%) lost weight, and 153 (15%) gained weight. These distributions were similar in the two study groups inclusive of all study participants and for only those women with a baseline body mass index of ≥ 25 kg/m2. Initial body mass index and changes in fiber and vegetable intakes, but not change in percent of energy obtained from fat, were associated independently with change in weight or body mass index.
For most women at risk for breast cancer recurrence, diet intervention to promote a reduction in fat intake was not associated with significant weight loss. Testing the effect of a substantial change in diet composition on risk for breast cancer recurrence is unlikely to be confounded by weight loss in subjects who were the recipients of intensive intervention efforts. Cancer 2001;91:25–34. © 2001 American Cancer Society.