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Extent of excision margin width required in breast conserving surgery for ductal carcinoma in situ
Article first published online: 4 JAN 2001
Copyright © 2001 American Cancer Society
Volume 91, Issue 1, pages 9–16, 1 January 2001
How to Cite
Chan, K. C., Knox, W. F., Sinha, G., Gandhi, A., Barr, L., Baildam, A. D. and Bundred, N. J. (2001), Extent of excision margin width required in breast conserving surgery for ductal carcinoma in situ. Cancer, 91: 9–16. doi: 10.1002/1097-0142(20010101)91:1<9::AID-CNCR2>3.0.CO;2-E
- Issue published online: 4 JAN 2001
- Article first published online: 4 JAN 2001
- Manuscript Revised: 5 SEP 2000
- Manuscript Accepted: 5 SEP 2000
- Manuscript Received: 24 FEB 2000
- Royal College of Surgeons of Edinburgh Jules Thorn Fellowship
- margin clearance;
- breast-conserving surgery (BCS);
- ductal carcinoma in situ (DCIS);
- adjuvant therapy
Breast conserving surgery (BCS) is common practice for unifocal ductal carcinoma in situ (DCIS) less than 4 cm in size, but the extent of tumor free margin width around DCIS necessary to minimize recurrence is unclear.
Clinical and pathologic details were recorded from all patients with pure DCIS < 4 cm in size, treated with BCS between 1978 and 1997. Histologic margins were measured by using an ocular micrometer. Patients with clear margins (> 1 mm) were divided up into 3 groups for analysis based on margin of normal tissue excised: 1.1–5 mm, 5.1–10 mm, and 10.1–40 mm.
There were 66 patients with close margins (≤ 1 mm), of which 25 cases (37.9%) recurred. The recurrence rates for the 3 clear margin groups ranged from 4.5–7.1%. Median followup was 47 months (range 12–197 mos). Risk of recurrence in the group with close margins was greater than the subgroups with clear margins (P < 0.001); no differences in recurrence was seen between the individual subgroups with clear margins. Nuclear Grade 3 was predictive of recurrence (P = 0.03). Following excision alone, the recurrence rate was 18.6%, compared with 11.1% when radiotherapy was given as adjuvant therapy. Women with clear margins following excision had a recurrence rate of only 8.1%.
After BCS for DCIS, close margins were associated with a high risk of local recurrence. Radiotherapy did not compensate for inadequate surgical clearance. Cancer 2001;91:9–16. © 2001 American Cancer Society.