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Anemia as an independent prognostic factor for survival in patients with cancer
A systematic, quantitative review
Article first published online: 13 JUN 2001
DOI: 10.1002/1097-0142(20010615)91:12<2214::AID-CNCR1251>3.0.CO;2-P
Copyright © 2001 American Cancer Society
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How to Cite
Caro, J. J., Salas, M., Ward, A. and Goss, G. (2001), Anemia as an independent prognostic factor for survival in patients with cancer. Cancer, 91: 2214–2221. doi: 10.1002/1097-0142(20010615)91:12<2214::AID-CNCR1251>3.0.CO;2-P
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Publication History
- Issue published online: 13 JUN 2001
- Article first published online: 13 JUN 2001
- Manuscript Accepted: 12 MAR 2001
- Manuscript Revised: 1 MAR 2001
- Manuscript Received: 10 JUL 2000
Funded by
- Janssen Ortho, Inc.
REFERENCES
- 1, , , , , . The relationship of pretreatment serum hemoglobin level to the survival of epithelial ovarian carcinoma patients. Cancer 1998; 83: 726–31.
- 2, . Erythropoietin therapy in cancer patients. Cas Leuk Ces 1995; 20: 647–50.
- 3
- 4, . Anemia in cancer patients. Semin Oncol 1998; 25(Suppl 7): 2–6.
- 5. Erythropoietin for anaemia in cancer patients. Eur J Cancer 1993; 29A(Suppl 2): S2–8.
- 6, , , , , . Impact of therapy with epoetin alpha on clinical outcomes in patients with nonmyeloid malignancies during cancer chemotherapy in community oncology practice. J Clin Oncol 1997; 15(3): 1218–34.
- 7, , , , . Quality-of-life benefit in chemotherapy patients treated with epoetin alpha is independent of disease response or tumor type: results from a prospective community oncology study. J Clin Oncol 1998; 16: 3412–25.
- 8, , , , . Once-weekly dosing of epoetin alpha is similar to three times weekly dosing in increasing hemoglobin and quality of life. Proc Am Soc Clin Oncol 1999; 18: 574A.
- 9. The causes and prognostic significance of low hemoglobin levels in tumor patients. Strahlenther Onkol 1998; 174(Suppl IV): 17–9.
- 10, . Anemia of cancer patients: patient selection and patient stratification for epoetin treatment. Semin Oncol 1998; 25(Suppl 7): 35–8.
- 11
- 12, , . Point estimation of overall effect and interval estimation of effect. In: KleinbaumDG, KupperLL, MorgensternH, editors. Epidemiologic research. Principles and quantitative methods, 1st edition. New York: Van Nostrand Reinhold, 1982: 340–76.
- 13, , . Cumulative meta-analysis of clinical trials builds evidence for exemplary medical care. J Clin Epidemiol 1995; 48: 45–57.
- 14, , , et al. Cumulative meta-analysis of therapeutic trials for myocardial infarction. N Engl J Med 1992; 327: 248–54.
- 15
- 16
- 17
- 18
- 19
- 20, , , , , , et al. The importance of maintaining high hemoglobin levels during radiation treatment of carcinoma of the cervix. Cancer 1999; 86: 1528–36.
- 21, , . Prognostic factors in inoperable adenocarcinoma of the lung. Cancer Res 1989; 49: 5748–54.
- 22, , , , . Prognostic factors for survival in inoperable non-small-cell lung cancer. A multivariate regression analysis of 456 patients with radiation therapy. Oncology 1997;20: 126–31.
- 23, , , , , , et al. Laboratory parameters as an alternative to performance status in prognostic stratification of patients with small cell lung cancer. Cancer Treat Rep 1981; 65: 187–95.
- 24, , . Survival and prognostic factors in lung cancer patients treated in Phase I trials: Japanese experience. Int J Oncol 1999; 15: 737–41.
- 25, . Prognostic factors in resected Stages I and II adenocarcinoma of the lung. A multivariate regression analysis of 137 consecutive patients. J Thorac Cardiovasc Surg 1990;99(2): 218-26.
- 26, . Prognostic factors in small cell lung cancer: multivariate model based on 778 patients treated with chemotherapy with or without irradiation. Cancer Res 1986; 46(8): 4189–94.
- 27, , , , , , et al. Prognostic factors of small-cell lung cancer in Okayama Lung Cancer Study Group trials. Acta Med Okayama 1998; 52(2): 105–11.
- 28, , , , , . Prognostic significance of laboratory parameters measured at prognosis in small cell carcinoma of the lung. Cancer Res 1985; 45: 2878–82.
- 29, , , , , , et al. A prognostic factor risk index in advanced non small cell lung cancer treated with cisplatin containing combination chemotherapy. Cancer Chemother Pharmacol 1992; 30: 1–6.
- 30, , , , , , et al. Prognostic factors in patients with resected stage non-small cell lung cancer. Cancer 1984; 54: 1802–13.
- 31, , , . Survival determinants in extensive-stage non-small cell lung cancer: the Southwest Oncology Group experience. J Clin Oncol 1991; 9: 1618–26.
- 32, , , , , , et al. Chemotherapy-induced anemia in patients with primary lung cancer. Ann Oncol 1992; 3(10): 819–24.
- 33, , . The impact of blood hemoglobin content on the outcome of radiotherapy. Strahlenther Onkol 1998; 174(Suppl IV): 31–4.
- 34, , , , , . A multivariate analysis of the prognosis of oral squamous cell carcinoma. Cancer 1991; 68: 1994–8.
- 35, , , , , , et al. Anemia is associated with decreased survival and increased locoregional failure in patients with locally advanced head and neck carcinoma: a secondary analysis of RTOG 85-27. Int J Radiat Oncol Biol Phys 1998; 42: 1069–75.
- 36, , , , , , et al. Anemia is associated with lower local-regional control and survival after radiation therapy for head and neck cancer: a prospective study. Radiology 1996; 201: 553–8.
- 37, , , , , . The role of hemoglobin concentration in the outcome of misonidazole-sensitized radiotherapy of head and neck cancers: based on RTOG trial 79-15. Int J Radiat Oncol Biol Phys 1989; 17(6): 1177–81.
- 38, , , , , , et al. Significance of pretreatment hemoglobin level in patients with T1 glottic cancer. Radiat Oncol Invest 1999; 7: 42–8.
- 39, , , . Primary radiotherapy of larynx and pharynx carcinoma- an analysis of some factors influencing local control and survival. Int J Radiat Oncol Biol Phys 1986; 12(4): 515–21.
- 40, , , , , , et al. Pretreatment hemoglobin level influences local control and survival of T1–T2 squamous cell carcinomas of the glottic larynx. J Clin Oncol 1995, 13(8): 2077–83.
- 41, , , , , , et al. Influence of the hypoxic subvolume on the survival of patients with head and neck cancer. Int J Radiat Oncol Biol Phys 1999; 44(4); 749–54.
- 42
- 43, , , . Prognostic factors in multiple myeloma in a population-based trial. Eur J Haematol 1990; 45: 198–202.
- 44
- 45, , , , , , et al. Prognostic factors in multiple myeloma in a population-based trial. Cancer 1975; 36: 1192–201.
- 46, , . Prognostic factors in multiple myeloma. Acta Haematol 1978; 60: 257–68.
- 47, , . Plasmacytic myeloma. Am J Med 1967; 42: 937–48.
- 48, , , . The influence of initial hemoglobin and blood pressure levels on results of radiation therapy for carcinoma of the prostate. Int J Radiat Oncol Biol Phys 1988; 16: 1173–8.
- 49, , , , . Effects of continued androgen-deprivation therapy and other prognostic factors on response and survival in Phase II chemotherapy trials for hormone-refractory prostate cancer: a Southwest Oncology Group report. J Clin Oncol 1994; 12(9): 1868–75.
- 50, , , , , and Members of the Dutch Southeastern Urological Cooperative Group. Analysis of prognostic factors in disseminated prostatic cancer. An update. Dutch Southeastern Urological Cooperative Group. Cancer 1990; 65(12): 2758–61.
- 51, , , , and Investigators of the National Prostatic Cancer Project. Prognostic factors in patients with advanced prostate cancer. Cancer Res 1985; 45: 5173–9.
- 52, , , . Change in serum prostate-specific antigen as a marker of response to cytotoxic therapy for hormone-refractory prostate cancer. J Clin Oncol 1998; 16: 1835–43.
- 53, , , , . Evaluation of prostate-specific antigen as a surrogate marker for response of hormone-refractory prostate cancer to suramin therapy. J Clin Oncol 1995; 13: 2944–53.
- 54, , . Association of hemoglobin levels before and during radiotherapy with prognosis in uterine cervix cancer. Radiology 1973; 106: 649–52.
- 55, , , . The effect of anemia on the radiotherapy results of the uterine cervix cancer. Neoplasma 1975; 22: 655–60.
- 56
- 57, . Factors affecting survival in over 500 patients with Stage II carcinoma of the cervix. Radiology 1977; 123: 181–3.
- 58French Cooperative Group on Chronic Lymphocytic Leukaemia. Natural history of Stage A chronic lymphocytic leukaemia untreated patients. Br J Haematol 1990; 76: 45–57.Direct Link:
- 59, . A multivariate analysis of prognostic factors in chronic myeloid leukemia. Blood 1982; 60: 1298–304.
- 60, , , , , , et al. Chronic myelogenous leukemia. Blood 1985; 66: 1326–35.
- 61, , , , . Acute lymphoblastic leukemia end results analysis of treatment and prognostic factors in Indian patients. Am J Hematol 1983; 15: 35–43.
- 62, , , , , , et al. Frequency and significance of anemia in non-Hodgkin's lymphoma patients. Ann Oncol 1998; 9: 1109–15.
- 63, , . Factors predicting long-term survival in diffuse mixed, histiocytic, or undifferentiated lymphoma. Blood 1981; 58: 45–51.
- 64, , , , , , et al. Prognostic factors among 185 adults with newly diagnosed advanced Hodgkin's disease with alternating potentially non-cross resistant chemotherapy and intermediate dose radiation therapy. J Clin Oncol 1990; 8: 1173–86.
- 65, , , , , , et al. Prognostic factors for survival in metastatic renal cell carcinoma: retrospective analysis from 109 consecutive patients. Eur Urol 1997; 31(3): 286–91.
- 66, . Prognostic factors for overall survival in patients with advanced ovarian carcinoma. Ann Oncol 1991; 2(4): 281–7.
- 67, , , . Determinants of prognosis in advanced colorectal cancer. Eur J Cancer 1991; 27(9): 1119–23.
- 68, , , , . Prognostic factors of advanced colorectal cancer patients. Eur J Cancer Clin Oncol 1986; 22: 1231–7.
- 69, , , . Factors affecting morbidity, mortality and survival after pancreaticoduodenectomy for carcinoma of the ampulla of Vater. Hepatogastroenterology 1999; 46: 1973–9.
- 70, , , , , . Factors predictive of survival among 337 patients with mesothelioma treated between 1984 and 1994 by the Cancer and Leukemia Group B. Chest 1998; 113(3): 723–31.
- 71, , , , , , et al. Long-term survival in metastatic transitional-cell carcinoma and prognostic factors predicting outcome of therapy. J Clin Oncol 1999; 17(10): 3173–81.
- 72, , . Implications of the anaemia of chronic disorders in patients anticipating radiotherapy. Am J Med Sci 1994; 308(1): 9–15.

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