You have free access to this content

Cancer

Cover image for Cancer

1 September 2001

Volume 92, Issue 5

Pages 1059–1348

  1. Original Articles

    1. Top of page
    2. Original Articles
    3. COMMUNICATION
    1. Disease Site

      Blood/Bone Marrow
      You have free access to this content
      Therapeutic options for acute myelogenous leukemia (pages 1059–1073)

      Elihu H. Estey

      Version of Record online: 18 SEP 2001 | DOI: 10.1002/1097-0142(20010901)92:5<1059::AID-CNCR1421>3.0.CO;2-K

      • original image
      • original image

      Various prognostic factors have been described in newly diagnosed acute myelogenous leukemia. These were reviewed and determined to be useful in planning treatment. Investigational regimens should be offered to most patients.

    2. You have free access to this content
      Hematologic recovery after central lymphatic irradiation for patients with stage I–III follicular lymphoma (pages 1074–1079)

      Chul S. Ha, Susan L. Tucker, Angel I. Blanco, Richard B. Wilder, Peter McLaughlin, Fernando Cabanillas and James D. Cox

      Version of Record online: 18 SEP 2001 | DOI: 10.1002/1097-0142(20010901)92:5<1074::AID-CNCR1422>3.0.CO;2-U

      • original image
      • original image
      • original image

      Approximately 80% of the bone marrow is radiated as a consequence of central lymphatic irradiation (CLI) for the treatment of patients with Stage I–III, low-grade follicular lymphoma. However, there is a slow but persistent recovery in the peripheral blood counts over years after a rapid phase of recovery within a few months after completion of CLI.

    3. Breast Disease
      You have free access to this content
      Is sentinel lymph node biopsy reliable and indicated after preoperative chemotherapy in patients with breast carcinoma? (pages 1080–1084)

      Anton Haid, Christoph Tausch, Alois Lang, Jörg Lutz, Heinz Fritzsche, William Peschina, Gerhard Breitfellner, Wolfgang Sega, Martin Aufschnaiter, Heinz Sturn and Gerhard Zimmermann

      Version of Record online: 18 SEP 2001 | DOI: 10.1002/1097-0142(20010901)92:5<1080::AID-CNCR1423>3.0.CO;2-1

      For staging patients with either operable breast carcinoma or more advanced disease, axillary status after preoperative chemotherapy was studied to determine whether sentinel lymph node status accurately represents axillary status. The results show that axillary dissection may be avoided in certain patients and that sentinel lymph node biopsy seems to be a reliable method for accurate staging of the axilla in patients with more advanced disease.

    4. You have free access to this content
      Significant correlation of monocyte chemoattractant protein-1 expression with neovascularization and progression of breast carcinoma (pages 1085–1091)

      Hisashi Saji, Morio Koike, Takao Yamori, Shigehira Saji, Motoharu Seiki, Kouji Matsushima and Masakazu Toi

      Version of Record online: 18 SEP 2001 | DOI: 10.1002/1097-0142(20010901)92:5<1085::AID-CNCR1424>3.0.CO;2-K

      • original image

      To determine the clinical significance of the role of monocyte chemoattractant protein-1 (MCP-1) in inducing the chemotactic migration of monocytes, MCP-1 expression was analyzed in breast carcinoma tissues. The results suggest that MCP-1 may be important in the recruitment of macrophages, in angiogenic factor expression, and in the activation of matrix metalloproteinases in patients with breast carcinoma.

    5. You have free access to this content
      Breast conservation therapy as a treatment option for the elderly : The M. D. Anderson experience (pages 1092–1100)

      Georges Vlastos, Nadeem Q. Mirza, Funda Meric, Kelly K. Hunt, Henry M. Kuerer, Frederick C. Ames, Merrick I. Ross, Thomas A. Buchholz, Gabriel N. Hortobagyi and S. Eva Singletary

      Version of Record online: 18 SEP 2001 | DOI: 10.1002/1097-0142(20010901)92:5<1092::AID-CNCR1425>3.0.CO;2-P

      • original image
      • original image
      • original image

      Breast conservation therapy provides excellent local control and disease free survival in elderly patients with breast carcinoma. This treatment option is appropriate for patients without severe comorbidities.

    6. Endocrine Disorders
      You have free access to this content
      Treatment with cisplatin and etoposide in patients with neuroendocrine tumors (pages 1101–1107)

      Marie-Louise H. Fjällskog, Dan. P. K. Granberg, Staffan L. V. Welin, Christopher Eriksson, Kjell E. Öberg, Eva T. Janson and Barbro K. Eriksson

      Version of Record online: 18 SEP 2001 | DOI: 10.1002/1097-0142(20010901)92:5<1101::AID-CNCR1426>3.0.CO;2-V

      • original image

      The combination of cisplatin and etoposide can produce significant responses in patients with heavily pretreated and poorly differentiated/rapidly progressing neuroendocrine tumors. The toxicity is considerable, and nephrotoxicity is the dose limiting factor.

    7. You have free access to this content
      Adjuvant chemotherapy for large cell carcinoma with neuroendocrine features (pages 1108–1112)

      Akira Iyoda, Kenzo Hiroshima, Tetsuya Toyozaki, Yukiko Haga, Masayuki Baba, Takehiko Fujisawa and Hidemi Ohwada

      Version of Record online: 18 SEP 2001 | DOI: 10.1002/1097-0142(20010901)92:5<1108::AID-CNCR1427>3.0.CO;2-7

      • original image
      • original image
      • original image

      The authors studied the effect of adjuvant chemotherapy for large cell carcinoma with neuroendocrine features. They found that adjuvant chemotherapy based on cisplatin, carboplatin, or cyclophosphamide might be able to prolong overall survival for patients with large cell carcinoma with neuroendocrine features in early stage.

    8. You have free access to this content
      Adrenocortical carcinoma : Clinical outcome at the end of the 20th century (pages 1113–1121)

      Rena Vassilopoulou-Sellin and Pamela N. Schultz

      Version of Record online: 18 SEP 2001 | DOI: 10.1002/1097-0142(20010901)92:5<1113::AID-CNCR1428>3.0.CO;2-I

      • original image
      • original image
      • original image
      • original image

      Adrenocortical carcinoma is a rare and lethal endocrine neoplasm. No significant improvements have emerged in treating the disease, but survival is now longer than in earlier decades.

    9. Gastrointestinal Tract
      You have free access to this content
      BCL2 expression correlates with metastatic potential in pancreatic cancer cell lines (pages 1122–1129)

      Richard J. Bold, Subbu Virudachalam and David J. McConkey

      Version of Record online: 18 SEP 2001 | DOI: 10.1002/1097-0142(20010901)92:5<1122::AID-CNCR1429>3.0.CO;2-H

      • original image
      • original image
      • original image
      • original image
      • original image

      Overexpression of the BCL2 protein has been correlated with tumor aggressiveness and resistance to cytotoxic therapy in pancreatic carcinoma. We report that overexpression of BCL2 also correlates with increased metastatic potential in pancreatic carcinoma.

    10. Genitourinary Disease
      You have free access to this content
      Prostate carcinoma risk and allelic variants of genes involved in androgen biosynthesis and metabolism pathways (pages 1130–1137)

      Alain G. Latil, Rahmène Azzouzi, Géraldine S. Cancel, Emmanuelle C. Guillaume, Béatrix Cochan-Priollet, Philippe L. Berthon and Olivier Cussenot

      Version of Record online: 18 SEP 2001 | DOI: 10.1002/1097-0142(20010901)92:5<1130::AID-CNCR1430>3.0.CO;2-B

      • original image

      CYP19 (aromatase), one of the genes involved in androgen pathways, was found to be an outstanding new indicator of prostate carcinoma risk among gene candidates for prostate carcinoma susceptibility.

    11. Gynecologic Oncology
      You have free access to this content
      Differential expression of angiopoietin-1 and angiopoietin-2 in colon carcinoma : A possible mechanism for the initiation of angiogenesis (pages 1138–1143)

      Syed A. Ahmad, Wenbiao Liu, Young D. Jung, Fan Fan, Niels Reinmuth, Corazon D. Bucana and Lee M. Ellis

      Version of Record online: 18 SEP 2001 | DOI: 10.1002/1097-0142(20010901)92:5<1138::AID-CNCR1431>3.0.CO;2-L

      • original image
      • original image

      Angiopoietin-1 and angiopoietin-2 (Ang-1 and Ang-2) are important mediators of endothelial cell survival. The current studies demonstrate that the endothelial cell-destabilizing factor Ang-2 is expressed in the epithelium of patients with colon carcinoma, whereas Ang-1 is not. In colon carcinoma, there is an imbalance in which the expression of Ang-2 exceeds the expression of Ang-1. This imbalance favoring Ang-2 activity may induce blood vessel destabilization and initiate angiogenesis in colon carcinoma.

    12. You have free access to this content
      GLUT-1 expression in ovarian carcinoma : Association with survival and response to chemotherapy (pages 1144–1150)

      Guilherme Cantuaria, Anna Fagotti, Gabriella Ferrandina, Albino Magalhaes, Merhad Nadji, Roberto Angioli, Manuel Penalver, Salvatore Mancuso and Giovanni Scambia

      Version of Record online: 18 SEP 2001 | DOI: 10.1002/1097-0142(20010901)92:5<1144::AID-CNCR1432>3.0.CO;2-T

      • original image

      GLUT-1 status may provide clinically useful prognostic information in patients with ovarian carcinoma. It is associated with response to chemotherapy and disease free survival.

    13. You have free access to this content
      Risk factors of endometrial polyps resected from postmenopausal patients with breast carcinoma treated with tamoxifen (pages 1151–1155)

      Ilan Cohen, Ron Azaria, Joel Bernheim, Jeremiah Shapira and Yoram Beyth

      Version of Record online: 18 SEP 2001 | DOI: 10.1002/1097-0142(20010901)92:5<1151::AID-CNCR1433>3.0.CO;2-Y

      Various factors, such as older age at menopause, longer duration of breast disease, heavier weight, and thicker endometrium, may contribute to the prediction of increased risk of development of endometrial polyps in postmenopausal patients with breast carcinoma treated with tamoxifen.

    14. You have free access to this content
      A Phase I–II study of 96-hour infusional topotecan and paclitaxel for patients with recurrent müllerian tumors (pages 1156–1167)

      Richard T. Penson, Jeffrey G. Supko, Michael V. Seiden, Arlan F. Fuller, Ross S. Berkowitz, Annekathryn Goodman, Susana M. Campos, Kimberley M. MacNeill, Sarah Cook and Ursula A. Matulonis

      Version of Record online: 18 SEP 2001 | DOI: 10.1002/1097-0142(20010901)92:5<1156::AID-CNCR1434>3.0.CO;2-G

      • original image

      The results of this Phase I–II study indicate that the combination of a 96-hour infusion of topotecan and paclitaxel shows activity in patients with tumors of Müllerian origin.

    15. You have free access to this content
      Inhibition of the UCI-107 human ovarian carcinoma cell line by a targeted cytotoxic analog of somatostatin, AN-238 (pages 1168–1176)

      Artur Plonowski, Andrew V. Schally, Miklos Koppan, Attila Nagy, Jose M. Arencibia, Balazs Csernus and Gabor Halmos

      Version of Record online: 18 SEP 2001 | DOI: 10.1002/1097-0142(20010901)92:5<1168::AID-CNCR1435>3.0.CO;2-6

      • original image
      • original image
      • original image
      • original image

      The effectiveness and toxicity of the targeted, cytotoxic analog of somatostatin, AN-238, was evaluated in a UCI-107 model of human ovarian carcinoma cells. The study demonstrates that AN-238 inhibits the growth of ovarian carcinoma cells that express somatostatin receptors, whereas its cytotoxic radical, 2-pyrrolinodoxorubicin (AN-201), is ineffective and toxic.

    16. You have free access to this content
      Possible associations among expression of p14ARF, p16INK4a, p21WAF1/CIP1, p27KIP1, and p53 accumulation and the balance of apoptosis and cell proliferation in ovarian carcinomas (pages 1177–1189)

      Makoto Saegusa, Daisuke Machida B. and Isao Okayasu

      Version of Record online: 18 SEP 2001 | DOI: 10.1002/1097-0142(20010901)92:5<1177::AID-CNCR1436>3.0.CO;2-5

      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image

      Several cyclin-dependent kinase inhibitors are expressed differently among histologic subtypes of ovarian carcinomas, associated with differences in tissue kinetics and the balance of apoptosis and cell proliferation.

    17. You have free access to this content
      The polymorphic CAG repeat in the androgen receptor gene in Jewish Israeli women with endometrial carcinoma (pages 1190–1194)

      Michal Yaron, Tally Levy, Angela Chetrit, Hanoch Levavi, Gad Sabah, David Schneider, Reuvit Halperin, Zion Ben-Rafael and Eitan Friedman

      Version of Record online: 18 SEP 2001 | DOI: 10.1002/1097-0142(20010901)92:5<1190::AID-CNCR1437>3.0.CO;2-L

      • original image
      • original image

      A polymorphic CAG repeat within exon 1 of the androgen receptor (AR) gene encodes for a polyglutamine tract whose length is inversely correlated with the transcriptional activity of the AR. In the current study, the germline AR-CAG repeat length was found to be significantly longer in Jewish patients with endometrial carcinoma compared with healthy controls. This finding increases the possibility that the AR is involved in the predisposition to this neoplasm.

    18. Head and Neck Disease
      You have free access to this content
      Upper respiratory tract carcinoma with chromosomal translocation 15;19 : Evidence for a distinct disease entity of young patients with a rapidly fatal course (pages 1195–1203)

      Sara O. Vargas, Christopher A. French, Peter N. Faul, Jonathan A. Fletcher, Ian J. Davis, Paola Dal Cin and Antonio R. Perez-Atayde

      Version of Record online: 18 SEP 2001 | DOI: 10.1002/1097-0142(20010901)92:5<1195::AID-CNCR1438>3.0.CO;2-3

      • original image
      • original image
      • original image
      • original image

      The authors present clinical and pathologic findings in two young female patients with carcinoma of the upper respiratory tract showing evidence of the chromosomal translocation 15;19. In conjunction with four previously reported studies of four separate patients, the authors' findings show that t(15;19) is part of a distinct clinicopathologic entity characterized by young age, midline carcinoma of the head, neck, or upper thorax, and a rapidly fatal course.

    19. Lung Disease
      You have free access to this content
      A randomized, prospective trial of central venous ports connected to standard open-ended or Groshong catheters in adult oncology patients (pages 1204–1212)

      Roberto Biffi, Filippo De Braud, Franco Orsi, Simonetta Pozzi, Patrizia Arnaldi, Aron Goldhirsch, Nicole Rotmensz, Chris Robertson, Massimo Bellomi and Bruno Andreoni

      Version of Record online: 18 SEP 2001 | DOI: 10.1002/1097-0142(20010901)92:5<1204::AID-CNCR1439>3.0.CO;2-9

      • original image

      The use of a Groshong™ catheter connected to a subcutaneous port for long-term delivery of chemotherapy was not superior to a traditional, open-ended catheter in terms of early and late complications of the implant and its use.

    20. You have free access to this content
      Dose-escalating conformal thoracic radiation therapy with induction and concurrent carboplatin/paclitaxel in unresectable stage IIIA/B nonsmall cell lung carcinoma : A modified phase I/II trial (pages 1213–1223)

      Mark A. Socinski, Julian G. Rosenman, Jan Halle, Michael J. Schell, Yuhua Lin, Suzanne Russo, M. Patricia Rivera, Jay Clark, Steven Limentani, Robert Fraser, William Mitchell and Frank C. Detterbeck

      Version of Record online: 18 SEP 2001 | DOI: 10.1002/1097-0142(20010901)92:5<1213::AID-CNCR1440>3.0.CO;2-0

      • original image
      • original image

      Incorporation of three-dimensional conformal treatment planning in the combined modality approach to unresectable Stage IIIA/B nonsmall cell lung carcinoma using sequential and concurrent carboplatin/paclitaxel is feasible and allows dose escalation of the thoracic radiation therapy dose to 74 gray. The toxicity profile of this approach is acceptable and the survival results are encouraging.

    21. You have free access to this content
      Hyaluronan content in pleural fluid as a prognostic factor in patients with malignant pleural mesothelioma (pages 1224–1230)

      Anders Thylén, Anders Hjerpe and Gunnar Martensson

      Version of Record online: 18 SEP 2001 | DOI: 10.1002/1097-0142(20010901)92:5<1224::AID-CNCR1441>3.0.CO;2-U

      • original image

      Survival is longer in patients with the epithelial and mixed histologic subtype of mesothelioma and an elevated content of hyaluronan in pleural fluid.

    22. You have free access to this content
      Variant expression of CD44 in preneoplastic lesions of the lung (pages 1231–1236)

      Anja Wimmel, Evguenia Kogan, Annette Ramaswamy and Marcus Schuermann

      Version of Record online: 18 SEP 2001 | DOI: 10.1002/1097-0142(20010901)92:5<1231::AID-CNCR1442>3.0.CO;2-Z

      • original image
      • original image

      The current study focuses on the expression of CD44 standard (CD44s) and its isoform CD44v6 in preneoplastic lesions of the lung. The pattern of CD44s and CD44v6 expression found anticipates the pattern of fully developed tumors, a pattern that is determined by the histopathologic background of the tumors. Based on this observation, the authors conclude that deregulation of the expression of the two isoforms occurs at an early point in lung carcinoma differentiation and may serve as a marker for screening in patients with this type of malignancy.

    23. Skin and Soft Tissue
      You have free access to this content
      Expression of apoptosis-related proteins, p53, and DNA fragmentation in sarcomas of the pulmonary artery (pages 1237–1244)

      Andreas Gaumann, Dominique S. Tews, Eckhard Mayer, Manfred Dahm, Peter K. Petrow, Mike Otto, C. James Kirkpatrick and Jörg Kriegsmann

      Version of Record online: 18 SEP 2001 | DOI: 10.1002/1097-0142(20010901)92:5<1237::AID-CNCR1443>3.0.CO;2-E

      • original image
      • original image

      Independent of p53, Bax was found to mediate apoptosis in pulmonary sarcomas. Host defense against the sarcoma was found to respond to mediation by perforin-expressing lymphocytes but was not mediated through the Fas/Fas-L pathway.

    24. Discipline

      Translational Research
      You have free access to this content
      p27kip1 immunoreactivity correlates with long-term survival in pleural malignant mesothelioma (pages 1245–1250)

      Massimo Bongiovanni, Paola Cassoni, Paolo De Giuli, Laura Viberti, Susanna Cappia, Cristiana Ivaldi, Luigi Chiusa and Gianni Bussolati

      Version of Record online: 18 SEP 2001 | DOI: 10.1002/1097-0142(20010901)92:5<1245::AID-CNCR1444>3.0.CO;2-G

      • original image
      • original image
      • original image
      • original image

      Survival in patients with pleural malignant mesothelioma can be predicted by immunohistochemical analysis of cell cycle–associated markers. The combined expression of high p27kip1 and low Ki-67 values identifies with 100% specificity and sensitivity long versus short survivors.

    25. You have free access to this content
      Detection of tumor cells in the portal and peripheral blood of patients with colorectal carcinoma using competitive reverse transcriptase-polymerase chain reaction (pages 1251–1258)

      Sotaro Sadahiro, Toshiyuki Suzuki, Nobuhiro Tokunaga, Satoshi Yurimoto, Seiei Yasuda, Tomoo Tajima, Hiroyasu Makuuchi, Chieko Murayama and Koichiro Matsuda

      Version of Record online: 18 SEP 2001 | DOI: 10.1002/1097-0142(20010901)92:5<1251::AID-CNCR1445>3.0.CO;2-O

      • original image

      Colorectal carcinoma cells can be detected in patients with early-stage disease. The majority of the tumor cells from the primary site are not arrested by the liver, but enter into the systemic circulation.

    26. Medical Oncology
      You have free access to this content
      Low-dose chemotherapy with methotrexate and vinblastine for patients with advanced aggressive fibromatosis (pages 1259–1264)

      Alberto Azzarelli, Alessandro Gronchi, Rossella Bertulli, John D. Tesoro Tess, Dario Baratti, Elisabetta Pennacchioli, Paltia Dileo, Alessandro Rasponi, Andrea Ferrari, Silvana Pilotti and Paolo G. Casali

      Version of Record online: 18 SEP 2001 | DOI: 10.1002/1097-0142(20010901)92:5<1259::AID-CNCR1446>3.0.CO;2-Y

      • original image
      • original image

      In a series of 30 patients with aggressive fibromatosis, the use of low-dose chemotherapy with methotrexate and vinblastine was confirmed as an option for the treatment of patients with inoperable disease, with a progression free interval in excess of 65% at 10 years.

    27. You have free access to this content
      A Phase I trial of h-ras antisense oligonucleotide ISIS 2503 administered as a continuous intravenous infusion in patients with advanced carcinoma (pages 1265–1271)

      C. Casey Cunningham, Jon T. Holmlund, Richard S. Geary, T. Jesse Kwoh, Andrew Dorr, Joseph F. Johnston, Brett Monia and John Nemunaitis

      Version of Record online: 18 SEP 2001 | DOI: 10.1002/1097-0142(20010901)92:5<1265::AID-CNCR1447>3.0.CO;2-5

      This report describes a Phase I trial of ISIS 2503, an antisense oligonucleotide against H-ras mRNA, given to patients with refractory solid tumors in escalating doses up to 10 mg/kg/day by continuous intravenous infusion for 14 days per cycle. Toxicity was acceptable and some patients had stabilization of disease, suggesting at least some growth-inhibitory effect.

    28. Radiation Oncology
      You have free access to this content
      The use of trimodality therapy for the treatment of operable esophageal carcinoma in the veteran population : Patient survival and outcome analysis (pages 1272–1280)

      Kevin G. Billingsley, Charles Maynard, David L. Schwartz and Jason A. Dominitz

      Version of Record online: 18 SEP 2001 | DOI: 10.1002/1097-0142(20010901)92:5<1272::AID-CNCR1448>3.0.CO;2-A

      • original image

      In this study examining patterns of care from the Veterans Affairs health care system, a subset of patients with operable esophageal carcinoma was chosen for induction chemoradiotherapy followed by surgery (trimodality therapy). In this retrospective review, patients selected for trimodality therapy had a survival equivalent to patients treated with surgery alone. The major predictors of survival were patient age, location of disease, and extent of disease.

    29. You have free access to this content
      Defining the optimal radiation dose with three-dimensional conformal radiation therapy for patients with nonmetastatic prostate carcinoma by using recursive partitioning techniques (pages 1281–1287)

      Eric M. Horwitz, Alexandra L. Hanlon, Wayne H. Pinover, Penny R. Anderson and Gerald E. Hanks

      Version of Record online: 18 SEP 2001 | DOI: 10.1002/1097-0142(20010901)92:5<1281::AID-CNCR1449>3.0.CO;2-9

      • original image
      • original image

      Using recursive partitioning techniques, the authors showed that radiation dose continues to be an important predictor of biochemical no evidence of disease control rates and that a radiation dose response exists for patients with clinically localized prostate carcinoma treated with three-dimensional conformal radiation therapy.

    30. Integrated Medicine
      You have free access to this content
      Impact of surgery and chemotherapy on the quality of life of younger women with breast carcinoma : A prospective study (pages 1288–1298)

      Neeraj K. Arora, David H. Gustafson, Robert P. Hawkins, Fiona McTavish, David F. Cella, Suzanne Pingree, John H. Mendenhall and David M. Mahvi

      Version of Record online: 18 SEP 2001 | DOI: 10.1002/1097-0142(20010901)92:5<1288::AID-CNCR1450>3.0.CO;2-E

      Although younger women with breast carcinoma reported improvement on several quality-of-life dimensions within the first year of diagnosis, they did experience a range of adjustment problems that varied with their treatment modalities. Social functioning, however, declined over time, independent of the type of treatment received.

    31. Epidemiology
      You have free access to this content
      The influence of urbanization, age, ethnicity, and income on the early diagnosis of breast carcinoma : Opportunity for screening improvement (pages 1299–1304)

      Herman R. Menck and Paul K. Mills

      Version of Record online: 18 SEP 2001 | DOI: 10.1002/1097-0142(20010901)92:5<1299::AID-CNCR1451>3.0.CO;2-7

      • original image

      Nonurban residence, elderly status, and ethnicity were associated with more advanced stage of disease at the time of initial diagnosis in patients with breast carcinoma. This suggests that these population groups should be targeted for more intensive mammographic screening.

    32. You have free access to this content
      Making effective use of tumor registries for cancer survivorship research (pages 1305–1314)

      Amber T. Pakilit, Barbara A. Kahn, Laura Petersen, Laura S. Abraham, Gail A. Greendale and Patricia A. Ganz

      Version of Record online: 18 SEP 2001 | DOI: 10.1002/1097-0142(20010901)92:5<1305::AID-CNCR1452>3.0.CO;2-M

      • original image

      This report describes how hospital cancer registries can be used to identify and recruit cancer survivors for the study of late effects after treatment. In this study, registries from a comprehensive cancer center and a community hospital were used for the efficient recruitment of a sample of breast cancer survivors 5–10 years after diagnosis for participation in a study of the late reproductive health effects of their treatment.

    33. You have free access to this content
      Lifestyle high-risk behaviors and demographics may predict the level of participation in sun-protection behaviors and skin cancer primary prevention in the united states : Results of the 1998 national health interview survey (pages 1315–1324)

      Beth R. Santmyire, Steven R. Feldman and Alan B. Fleischer Jr.

      Version of Record online: 18 SEP 2001 | DOI: 10.1002/1097-0142(20010901)92:5<1315::AID-CNCR1453>3.0.CO;2-I

      • original image
      • original image
      • original image
      • original image
      • original image

      Data on reported sun-protection behaviors and skin cancer examinations were obtained from surveys that were completed by adults in the 1998 National Health Interview Survey. The likelihood of participation in sun-protective behaviors and skin cancer prevention was affected by a number of demographic characteristics and high-risk behaviors, including currently smoking cigarettes and wearing seatbelts.

    34. You have free access to this content
      Chronic lymphocytic leukemia incidence is substantially higher than estimated from tumor registry data (pages 1325–1330)

      Clive S. Zent, Mouhammed J. Kyasa, Richard Evans and Steven A. Schichman

      Version of Record online: 18 SEP 2001 | DOI: 10.1002/1097-0142(20010901)92:5<1325::AID-CNCR1454>3.0.CO;2-E

      • original image

      Standard tumor registries are not designed to record diagnoses of chronic lymphocytic leukemia (CLL) made by flow cytometric analysis of peripheral blood cells. In the current study, the authors demonstrate that with the increased use of peripheral blood immunophenotype as the sole method of diagnosing CLL, the percentage of patients with a new diagnosis of CLL recorded by a standard tumor registry over a period of 10 years decreased from 100% to 34.5%. These data suggest that the true incidence of CLL may be higher than estimated based on tumor registry data.

    35. Pathology

      Pathology
      You have free access to this content
      Epidermal growth factor receptor immunohistochemical reactivity in patients with American Joint Committee on Cancer Stage IV colon adenocarcinoma : Implications for a standardized scoring system (pages 1331–1346)

      Neal S. Goldstein and Maryiam Armin

      Version of Record online: 18 SEP 2001 | DOI: 10.1002/1097-0142(20010901)92:5<1331::AID-CNCR1455>3.0.CO;2-M

      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image

      Epidermal growth factor receptor (EGFR) is present in the majority of colon adenocarcinomas. The results of the current study demonstrate that EGFR reactivity increases with increasing depth of invasion. EGFR expression in metastases appear to correlate best with EGFR in the deepest regions of tumor invasion.

  2. COMMUNICATION

    1. Top of page
    2. Original Articles
    3. COMMUNICATION
    1. You have free access to this content
      Pilot study of vitaxin—an angiogenesis inhibitor—in patients with advanced leiomyosarcomas (pages 1347–1348)

      Shreyaskumar R. Patel, Jan Jenkins R.N., Nicholas Papadopolous, M. Andrew Burgess, Carl Plager, Jordan Gutterman and Robert S. Benjamin

      Version of Record online: 18 SEP 2001 | DOI: 10.1002/1097-0142(20010901)92:5<1347::AID-CNCR1456>3.0.CO;2-0

SEARCH

SEARCH BY CITATION