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Early quality of life in patients with localized prostate carcinoma
An examination of treatment-related, demographic, and psychosocial factors
Article first published online: 27 SEP 2001
Copyright © 2001 American Cancer Society
Volume 92, Issue 6, pages 1451–1459, 15 September 2001
How to Cite
Eton, D. T., Lepore, S. J. and Helgeson, V. S. (2001), Early quality of life in patients with localized prostate carcinoma. Cancer, 92: 1451–1459. doi: 10.1002/1097-0142(20010915)92:6<1451::AID-CNCR1469>3.0.CO;2-R
- Issue published online: 27 SEP 2001
- Article first published online: 27 SEP 2001
- Manuscript Accepted: 12 JUN 2001
- Manuscript Revised: 16 MAY 2001
- Manuscript Received: 13 OCT 2000
- National Institute of Mental Health. Grant Number: T32 MH19953
- National Cancer Institute. Grant Number: RO1 CA68354
- quality of life;
- prostate carcinoma;
- radical prostatectomy;
- social environment;
Men with localized prostate carcinoma are faced with important treatment decisions, and quality of life (QoL) information has become a crucial element of decision making. The first objective of this study was to compare the early, health-related QoL (HRQoL) of men with localized prostate carcinoma who were treated with radical prostatectomy, external beam radiotherapy, or brachytherapy. A second objective was to identify demographic and psychosocial variables that predict HRQoL.
Two-hundred fifty-six men with localized prostate carcinoma were interviewed within 7 weeks of treatment initiation. The interview included measures of prostate-specific HRQoL (the University of California—Los Angeles Prostate Cancer Index), general HRQoL (the SF-36), and psychosocial variables.
After adjusting for covariates, treatment group differences were found for both prostate specific HRQoL and general HRQoL. Men who underwent prostatectomy reported more urinary and sexual problems and more general physical dysfunction compared with men who were treated with either form of radiation therapy. Men who were treated with brachytherapy reported the fewest problems in sexual function and the least general physical dysfunction. Few treatment group differences were found in mental functioning. Both demographic factors and psychosocial factors predicted HRQoL. Older men and African-American men reported more physical problems than younger men and Caucasian men, respectively. A supportive social environment, high self-efficacy, and high self-esteem were predictive of better HRQoL.
Shortly after undergoing treatment for localized prostate carcinoma, men who underwent radical prostatectomy, older men, and African-American men are at heightened risk for experiencing prostate-specific and general deficits in HRQoL. Having psychosocial resources from which to draw may enhance HRQoL. Cancer 2001;92:1451–9. © 2001 American Cancer Society.