• Anichini, A., Mortarini, R., Macalli, C., Sqarcina, P., Fleischhauer, K., Mascheroni, L. and Parmiani, G., Cytotoxic T cells directed to tumor antigens not expressed on normal melanocytes dominate HLA-A2.1-restricted immune repertoire to melanoma. J. Immunol., 156, 208-217 (1996).
  • Di Fabio et al., Quantification of human influenza virus-specific cytotoxic T lymphocytes: correlation of cytotoxicity and increased number of IFNγ producing CD8+ T cells. Int. Immunol., 6, 11-19 (1994).
  • Faure, F., Even, J. and Kourisly, P., Tumor-specific immune response: current in vitro analyses may not reflect the in vivo immune status. Crit. Rev. Immunol., 18(1-2), 77-86 1998).
  • Hamann, D., Baars, P., Rep, M., Hooibrink, B., Kerkhof-Garde, S., Klein, M. and Van Lier, R., Phenotypical and functional separation of memory and effector human CD8+ T cells. J. Exp. Med., 186, 1407-1418 (1997).
  • Herr, W., Schneider, J., Lohse, A. W., Meyer zum Bueschenfelde, K.-H. and Woelfel, T., Detection and quantification of blood-derived CD8+T lymphocytes secreting TNFa in response to HLA-A2.1-binding melanoma and viral peptide antigens. J. Immunol. Method. 191, 131-143 (1996).
  • Hom, S., Schwarztentrubber, D., Rosenberg, S. and Topalian, S., Specific release of cytokines by lymphocytes infiltrating human melanomas in response to shared antigens. J. Immunother. 13, 18-30 (1993).
  • Marincola, F., The multiple ways to tumor tolerance. J. Immunother. 20(3), 178-179 1997).
  • Mazzocchi, A., Storkus, W., Traversari, C., Tarsini, P., Maeurer, M., Rivoltini, L., Vegetti, C., Belli, F., Anichini, A., Parmiani, G. and Castelli, C., Multiple melanoma-associated epitopes recognized by HLA-A3-restricted CTLs and shared by melanomas but not melanocytes. J. Immunol., 157(7), 3030-3038 1996).
  • Miyahira, et al., Quantification of antigen specific CD8+ T cells using an ELISPOT assay. J. Immunol. Methods, 181, 45-54 (1995).
  • Lee, P., Yee, C., Savage, P., Fong, L., Brockstedt, D., Weber, J., Johnson, D., Swetter, S., Thompson, J., Greenberg, P., Roederer, M. and Davis, M., Characterisation of circulating T cells specific for tumor-associated antigens in melanoma patients. Nature (Med.), 5(6), 677-685 1999).
  • Robbins, P. and Kawakami, Y., Human tumor antigens recognized by T cells. Curr. Opin. Immunol., 8, 628-636 (1996).
  • Scheibenbogen, C., Lee, K. H., Mayer, S., Stefanovic, S., Moebius, U., Herr, W., Rammensee, H. G. and Keilkolz, U., A sensitive Elispot assay for detection of CD8+ lymphocytes specific for HLA class I-binding peptide epitopes derived from influenza proteins in the blood of healthy donors and melanoma patients. Clin. Cancer Res. 3, 221-226 (1997).
  • Slingluff, C., Graham, D., Skipper, J., Kittlesen, D., Deacon, D., Colella, T., Harthun, N., Huczko, E., Darrow, T., Innes, D., Golden, W. and Engelhard, V., Immunologic escape variant melanomas with normal MHC expression and antigen processing lack multiple melanocytic differentiation antigens. J. Immunother., 19, 460 (1996).