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The Breast Cancer Information Core: Database design, structure, and scope†

  1. Csilla Szabo1,
  2. Anthony Masiello2,
  3. Joseph F. Ryan2,
  4. Lawrence C. Brody2,*

Article first published online: 28 JUL 2000

DOI: 10.1002/1098-1004(200008)16:2<123::AID-HUMU4>3.0.CO;2-Y

Issue

Human Mutation

Human Mutation

Volume 16, Issue 2, pages 123–131, August 2000

Additional Information

How to Cite

Szabo, C., Masiello, A., Ryan, J. F. and Brody, L. C. (2000), The Breast Cancer Information Core: Database design, structure, and scope. Human Mutation, 16: 123–131. doi: 10.1002/1098-1004(200008)16:2<123::AID-HUMU4>3.0.CO;2-Y

Author Information

  1. 1

    Unit of Genetic Epidemiology, International Agency for Research on Cancer, Lyon, France

  2. 2

    Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland

*Genetics and Molecular Biology Branch, National Human Genome Research Institute, 49 Convent Drive, Room 3A14, Bethesda, MD 20892-4442

  1. †

    The BIC database is accessible through the World Wide Web site hosted by the National Human Genome Research Institute, USA: http://www.nhgri.nih.gov/Intramural_research/Lab_transfer/Bic/

Publication History

  1. Issue published online: 28 JUL 2000
  2. Article first published online: 28 JUL 2000
  3. Manuscript Accepted: 21 APR 2000
  4. Manuscript Received: 10 NOV 1999

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Keywords:

  • BRCA1;
  • BRCA2;
  • breast cancer;
  • mutation database;
  • MDI

Abstract

The Breast Cancer Information Core (BIC) is an open access, on-line mutation database for breast cancer susceptibility genes. In addition to creating a catalogue of all mutations and polymorphisms in breast cancer susceptibility genes, a principle aim of the BIC is to facilitate the detection and characterization of these genes by providing technical support in the form of mutation detection protocols, primer sequences, and reagent access. Additional information at the site includes a literature review compiled from published studies, links to other internet-based, breast cancer information and research resources, and an interactive discussion forum which enables investigators to post or respond to questions and/or comments on a bulletin board. Hum Mutat 16:123–131, 2000. Published 2000 Wiley-Liss, Inc.

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