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Abstract

Twenty females with bulimia nervosa over the age of 18 monitored their eating behavior and purge frequency for 1 week before and after 16 weeks of treatment with imipramine or placebo using a standard diary. There was a significantly greater decrease in purged calories for subjects in the imipramine group once pretreatment group differences were covaried out, confirming the action of imipramine on binge eating. Subjects in both groups consumed approximately 1000 kcal/day excluding purged calories with no significant difference between groups on this measure. Nonpurged caloric intake did not increase over time, indicating continuation of a highly restricted eating pattern following medication treatment. During binges subjects in both groups combined, before and after treatment, consumed an average of 1485 kcal, although there was considerable variability associated with this mean.