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Implementing a unified approach to family-based tests of association

  1. Nan M. Laird1,*,
  2. Steve Horvath1,2,
  3. Xin Xu3

Article first published online: 25 OCT 2000

DOI: 10.1002/1098-2272(2000)19:1+<::AID-GEPI6>3.0.CO;2-M

Issue

Genetic Epidemiology

Genetic Epidemiology

Supplement: National Institutes of Health Statistical Genetics Initiative Symposium (Issue edited by: Steven O. Moldin)

Volume 19, Issue Supplement 1, pages S36–S42, 2000

Additional Information

How to Cite

Laird, N. M., Horvath, S. and Xu, X. (2000), Implementing a unified approach to family-based tests of association. Genet. Epidemiol., 19: S36–S42. doi: 10.1002/1098-2272(2000)19:1+<::AID-GEPI6>3.0.CO;2-M

Author Information

  1. 1

    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts

  2. 2

    Institute for Medical Biometry, Informatics, and Epidemiology, University of Bonn, Bonn, Germany

  3. 3

    Program in Population Genetics, Harvard School of Public Health, Boston, Massachusetts

*Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115

Publication History

  1. Issue published online: 25 OCT 2000
  2. Article first published online: 25 OCT 2000

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Keywords:

  • tests of association;
  • family based controls;
  • transmission disequilibrium tests

Abstract

We describe a broad class of family-based association tests that are adjusted for admixture; use either dichotomous or measured phenotypes; accommodate phenotype-unknown subjects; use nuclear families, sibships or a combination of the two, permit multiple nuclear families from a single pedigree; incorporate di- or multi-allelic marker data; allow additive, dominant or recessive models; and permit adjustment for covariates and gene-by-environment interactions. The test statistic is the covariance between a user-specified function of the genotype and a user-specified function of the trait. The distribution of the statistic is computed using the appropriate conditional distribution of offspring genotypes that adjusts for admixture. Genet. Epidemiol. 19(Suppl 1):S36–S42, 2000. © 2000 Wiley-Liss, Inc.

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