Implementing a unified approach to family-based tests of association
Article first published online: 25 OCT 2000
Copyright © 2000 Wiley-Liss, Inc.
Supplement: National Institutes of Health Statistical Genetics Initiative Symposium (Issue edited by: Steven O. Moldin)
Volume 19, Issue Supplement 1, pages S36–S42, 2000
How to Cite
Laird, N. M., Horvath, S. and Xu, X. (2000), Implementing a unified approach to family-based tests of association. Genet. Epidemiol., 19: S36–S42. doi: 10.1002/1098-2272(2000)19:1+<::AID-GEPI6>3.0.CO;2-M
- Issue published online: 25 OCT 2000
- Article first published online: 25 OCT 2000
- tests of association;
- family based controls;
- transmission disequilibrium tests
We describe a broad class of family-based association tests that are adjusted for admixture; use either dichotomous or measured phenotypes; accommodate phenotype-unknown subjects; use nuclear families, sibships or a combination of the two, permit multiple nuclear families from a single pedigree; incorporate di- or multi-allelic marker data; allow additive, dominant or recessive models; and permit adjustment for covariates and gene-by-environment interactions. The test statistic is the covariance between a user-specified function of the genotype and a user-specified function of the trait. The distribution of the statistic is computed using the appropriate conditional distribution of offspring genotypes that adjusts for admixture. Genet. Epidemiol. 19(Suppl 1):S36–S42, 2000. © 2000 Wiley-Liss, Inc.