Behavioral phenotype of individuals with Down syndrome
Article first published online: 12 JUN 2000
Copyright © 2000 Wiley-Liss, Inc.
Mental Retardation and Developmental Disabilities Research Reviews
Special Issue: Specific Behavioral/Cognitive Phenotypes of Genetic Disorders
Volume 6, Issue 2, pages 84–95, 2000
How to Cite
Chapman, R. S. and Hesketh, L. J. (2000), Behavioral phenotype of individuals with Down syndrome. Ment. Retard. Dev. Disabil. Res. Rev., 6: 84–95. doi: 10.1002/1098-2779(2000)6:2<84::AID-MRDD2>3.0.CO;2-P
- Issue published online: 12 JUN 2000
- Article first published online: 12 JUN 2000
- National Institutes of Health and National Down Syndrome Society. Grant Number: R01HD23353.
- Down syndrome;
- social skills;
- behavioral development
Evidence is reviewed for a developmentally-emerging behavioral phenotype in individuals with Down syndrome that includes significant delay in nonverbal cognitive development accompanied by additional, specific deficits in speech, language production, and auditory short-term memory in infancy and childhood, but fewer adaptive behavior problems than individuals with other cognitive disabilities. Evidence of dementia emerges for up to half the individuals studied after age 50. Research issues affecting control group selection in establishing phenotypic characteristics are discussed, as well as the possible genetic mechanisms underlying variation in general cognitive delay, specific language impairment, and adult dementia. MRDD Research Reviews 2000;6:84-95. Wiley-Liss, Inc.