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Antiepileptics

  1. Klaus Unverferth1,
  2. Piotr Wlaz2,
  3. Chris Rundfeldt3

Published Online: 15 APR 2008

DOI: 10.1002/14356007.a03_013.pub2

Ullmann's Encyclopedia of Industrial Chemistry

Ullmann's Encyclopedia of Industrial Chemistry

How to Cite

Unverferth, K., Wlaz, P. and Rundfeldt, C. 2008. Antiepileptics. Ullmann's Encyclopedia of Industrial Chemistry. .

Author Information

  1. 1

    elbion GmbH, Radebeul, Germany

  2. 2

    Department of Animal Physiology, Maria Curie-Sklodowska University, Lublin, Poland

  3. 3

    Drug-Consult.Net, Magdeburg, Germany

Publication History

  1. Published Online: 15 APR 2008

Chemistry Terms

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Abstract

Epilepsy is a condition of recurrent, paroxysmal seizures. The treatment of epilepsy is based on pharmacotherapy to suppress the seizure attacks, behavioral therapy to avoid seizure-initiating situations, and on surgical resection of the seizure focus. As yet no ideal and general treatment regime exists for epileptic patients, the therapy rather has to be adopted individually.

With optimal usage of the aforementioned strategies, seizures can be fully controlled in about 70 – 80 % of patients; however, side effects often have to be accepted.

Currently available anticonvulsants can be grouped into first-generation drugs, which were marketed before 1975, and new drugs, i.e., drugs which were marketed 1989 or later. Although since 1989 nine new drugs have been marketed, the progress made especially in treatment-resistant patients can be only considered incremental.

Therefore, the need for new anticonvulsants which are effective in treatment-resistant patients and which are better tolerated still exists.

The article contains sections titled:

1.Introduction
1.1.Classification
1.2.Treatment of Epilepsy
1.3.Discovery Strategies for New Antiepileptic Drugs
2.Antiepileptic Drugs
2.1.Phenytoin
2.2.Carbamazepine and Oxcarbazepine
2.3.Valproic Acid
2.4.Ethosuximide and Trimethadione
2.5.Phenobarbital and Primidone
2.6.Benzodiazepines
2.7.New Drugs
2.8.Other Antiepileptic Drugs

Featured Compounds

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  1. 1 - 24
Compound 9
Molecular Weight:154.1665
Molecular Formula:C7H10N2O2
InChIKey:XHRGUQBJMOCCMF-UHFFFAOYSA-N
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Compound 15
Molecular Weight:211.2576
Molecular Formula:C11H17NO3
InChIKey:RJHVHVWQYPAMDN-UHFFFAOYSA-N
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Compound 12
Molecular Weight:248.281
Molecular Formula:C12H16N4O2
InChIKey:KIQBGZAXWNPFEU-UHFFFAOYSA-N
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Compound 18
Molecular Weight:327.303
Molecular Formula:C14H15BrS2
InChIKey:KRXSGXVUQKRSCK-UHFFFAOYSA-N
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Compound 7
Molecular Weight:129.114
Molecular Formula:C5H7NO3
InChIKey:JYJFNDQBESEHJQ-UHFFFAOYSA-N
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Compound 22
Molecular Weight:232.275
Molecular Formula:C14H16O3
InChIKey:LXFNQCGNCFRKRR-FNORWQNLSA-N
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Compound 5
Molecular Weight:160.1678
Molecular Formula:C7H12O4
InChIKey:FDYJJKHDNNVUDR-UHFFFAOYSA-N
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Compound 1
Molecular Weight:223.2698
Molecular Formula:C15H13NO
InChIKey:ZKHZWXLOSIGIGZ-UHFFFAOYSA-N
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Compound 2
Molecular Weight:266.2946
Molecular Formula:C16H14N2O2
InChIKey:PIZOFBKQWNPKDK-UHFFFAOYSA-N
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Compound 3
Molecular Weight:218.2533
Molecular Formula:C15H10N2
InChIKey:KMJHZCLHURUEKI-UHFFFAOYSA-N
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Compound B
Molecular Weight:299.3658
Molecular Formula:C21H17NO
InChIKey:HPCYLTILMWPHLP-UHFFFAOYSA-N
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Compound 19
Molecular Weight:157.2102
Molecular Formula:C8H15NO2
InChIKey:XIWBSOUNZWSFKU-SSDOTTSWSA-N
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Compound A
Molecular Weight:344.4495
Molecular Formula:C23H24N2O
InChIKey:YTDFCZYTPAVCMF-UHFFFAOYSA-N
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Compound 21
Molecular Weight:214.2582
Molecular Formula:C11H18O4
InChIKey:KHLQZLQKIPCFJF-UHFFFAOYSA-N
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Compound 20
Molecular Weight:102.135
Molecular Formula:C4H10N2O
InChIKey:HNNJFUDLLWOVKZ-VKHMYHEASA-N
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Compound 10
Molecular Weight:209.457
Molecular Formula:C7H3Cl3O
InChIKey:YBONBWJSFMTXLE-UHFFFAOYSA-N
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Compound 14
Molecular Weight:197.231
Molecular Formula:C10H15NO3
InChIKey:ZBAUSHIGYKKATD-UHFFFAOYSA-N
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Compound 8
Molecular Weight:212.2423
Molecular Formula:C11H16O4
InChIKey:UOQTXZICFVMERR-UHFFFAOYSA-N
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Compound 11
Molecular Weight:200.022
Molecular Formula:C8H3Cl2NO
InChIKey:FIBBFBXFASKAON-UHFFFAOYSA-N
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Compound 6
Molecular Weight:132.1577
Molecular Formula:C6H12O3
InChIKey:GFUIDHWFLMPAGY-UHFFFAOYSA-N
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Compound 17
Molecular Weight:260.2836
Molecular Formula:C12H20O6
InChIKey:PSSHGMIAIUYOJF-XBWDGYHZSA-N
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Compound 16
Molecular Weight:243.2994
Molecular Formula:C12H21NO4
InChIKey:XBCUTKBYIBLQDE-UHFFFAOYSA-N
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Compound 13
Molecular Weight:214.2582
Molecular Formula:C11H18O4
InChIKey:VLFQWYHVTAGEQB-UHFFFAOYSA-N
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Compound 4
Molecular Weight:263.2509
Molecular Formula:C15H9N3O2
InChIKey:HENMVDHJHVQKCQ-UHFFFAOYSA-N
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  1. 1 - 24