Published Online: 15 JUL 2008
Copyright © 2002 by Wiley-VCH Verlag GmbH & Co. KGaA
Ullmann's Encyclopedia of Industrial Chemistry
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Hennemann, J., Schatton, W. and Lyssy, R. H. 2008. Parkinsonism Treatment. Ullmann's Encyclopedia of Industrial Chemistry. .
- Published Online: 15 JUL 2008
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Pharmacological treatment of Parkinson's Disease (PD) has made remarkable progress over the past 50 years and can lead to significant improvement in the quality of life of PD patients. However, for some patients pharmacological therapy can be ineffective at alleviating PD symptoms. Furthermore, long-term usage of drugs, especially the gold standard levodopa, can lead to complications. Alternative nondrug therapies have been developed to avoid these difficulties. Transplantation of embryonic tissue did not meet the high expectations resulting from the first open label trials. Different procedures such as implantation of retinal epithelial cells or gene therapy are currently still part of clinical testing. Overall, a balanced application of the available therapies can improve PD symptoms for 15–25 years and guarantee a good to satisfactory quality of life and significantly increase the life expectancy of PD patients.