Standard Article

Prostaglandins

  1. Bernd Buchmann,
  2. Hartmut Rehwinkel

Published Online: 15 JUL 2007

DOI: 10.1002/14356007.a22_261.pub2

Ullmann's Encyclopedia of Industrial Chemistry

Ullmann's Encyclopedia of Industrial Chemistry

How to Cite

Buchmann, B. and Rehwinkel, H. 2007. Prostaglandins. Ullmann's Encyclopedia of Industrial Chemistry. .

Author Information

  1. Medicinal Chemistry, Bayer Schering Pharma AG, Berlin, Federal Republic of Germany

Publication History

  1. Published Online: 15 JUL 2007

Abstract

The article contains sections titled:

1.History
2.Structure, Nomenclature, and Physical Properties
3.Occurrence and Biosynthesis
4.Pharmacological Effects and Uses
5.Syntheses

Prostaglandins are formed from arachidonic acid. Those and all other derivatives of arachidonic acid, e.g., prostacyclins, thromboxanes, leukotrienes, and lipoxines are called eicosanoids. Most eicosanoids are chemically and metabolically unstable. Therefore, many pharmaceutical companies have tried to improve the stability by modifying the original structures. Several of these analogues have already reached the market in different therapeutic indications or show promising results in clinical trials. This article describes the chemical and pharmacological properties of the natural derivatives and their analogues as well as the synthetic access to some of the natural compounds.

Featured Compounds

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  1. 1 - 41
Compound 28
Molecular Weight:413.346
Molecular Formula:C20H29BrO4
InChIKey:KZVGMNCYRIMKMD-RTYORKEASA-N
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Compound 12
Molecular Weight:130.1418
Molecular Formula:C6H10O3
InChIKey:XYIBRDXRRQCHLP-UHFFFAOYSA-N
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Compound 29
Molecular Weight:318.4812
Molecular Formula:C15H30O5Si
InChIKey:PADRRUBRYKBOAV-GADZMNMWSA-N
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Compound 10
Molecular Weight:436.5815
Molecular Formula:C25H40O6
InChIKey:URJZFTOBSFDMMQ-AVPAPQIJSA-N
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Compound 22
Molecular Weight:494.4041
Molecular Formula:C21H35IO5
InChIKey:HEYIFYKGKHAVCV-DSYOVVJXSA-N
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Compound 8
Molecular Weight:370.4388
Molecular Formula:C22H26O5
InChIKey:OCWSJGXEQPXXSZ-QSQWMDCWSA-N
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Compound 35
Molecular Weight:264.2738
Molecular Formula:C14H16O5
InChIKey:KTLZBZAZFHLSIC-LBPRGKRZSA-N
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Compound 5
Molecular Weight:262.301
Molecular Formula:C15H18O4
InChIKey:VYDFIBNRVCCZAQ-MGPQQGTHSA-N
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Compound 15
Molecular Weight:322.396
Molecular Formula:C18H26O5
InChIKey:VDKRCABVOSBFSK-UKVHHCBFSA-N
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Compound 38
Molecular Weight:232.2304
Molecular Formula:C10H16O6
InChIKey:LBZQAFIJMYVWQZ-JGVFFNPUSA-N
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Compound 13
Molecular Weight:252.2631
Molecular Formula:C13H16O5
InChIKey:PAYHREWLKQHVQN-RQOWECAXSA-N
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Compound 27
Molecular Weight:431.361
Molecular Formula:C20H31BrO5
InChIKey:NVJAKINBIQOYJM-XJCNADTHSA-N
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Compound 30
Molecular Weight:540.828
Molecular Formula:C28H48O6SSi
InChIKey:QHQRTEDRHRSRIC-XWENLFJESA-N
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Compound 1
Molecular Weight:186.2497
Molecular Formula:C13H14O
InChIKey:DHVIVNRYFOAZFF-UHFFFAOYSA-N
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Compound 3
Molecular Weight:228.2863
Molecular Formula:C15H16O2
InChIKey:LSDGHFTXHLNHLS-UHFFFAOYSA-N
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Compound 17
Molecular Weight:366.4917
Molecular Formula:C21H34O5
InChIKey:WGCXTGBZBFBQPP-MQHLXXQOSA-N
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Compound 18
Molecular Weight:212.3608
Molecular Formula:C11H20O2Si
InChIKey:DAPZSGCXUJECAI-JTQLQIEISA-N
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Compound 6
Molecular Weight:492.3036
Molecular Formula:C22H21IO5
InChIKey:XIUGQSLLWFYSCH-SYGLAOGMSA-N
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Compound 23
Molecular Weight:124.1836
Molecular Formula:C7H12N2
InChIKey:Not Available
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Compound 36
Molecular Weight:454.5983
Molecular Formula:C28H38O5
InChIKey:KWWZXJNZRNLLEN-WUHQPNEGSA-N
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Compound 19
Molecular Weight:248.406
Molecular Formula:C14H29LiOSi
InChIKey:MBAZVNLUSWEGPC-BTQNPOSSSA-N
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Compound 7
Molecular Weight:276.2845
Molecular Formula:C15H16O5
InChIKey:OBRRYUZUDKVCOO-FVCCEPFGSA-N
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Compound 21
Molecular Weight:595.0134
Molecular Formula:C33H62O5Si2
InChIKey:CTJFMXDAAHQBTC-OWCGQNQPSA-N
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Compound 24
Molecular Weight:366.4917
Molecular Formula:C21H34O5
InChIKey:HEPKWABQTOCTFQ-DWLLSEBSSA-N
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Compound 34
Molecular Weight:549.521
Molecular Formula:C32H38BrOP
InChIKey:MRSJVZGTYOAYRC-DDRKWAPWSA-M
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Compound 4
Molecular Weight:244.2857
Molecular Formula:C15H16O3
InChIKey:YAJYWKFJTIRZIJ-UHFFFAOYSA-N
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Compound 41
Molecular Weight:506.7467
Molecular Formula:C28H46O6Si
InChIKey:VSHDNFQXXKLTPP-ZSJYLIDRSA-N
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Compound 33
Molecular Weight:206.3239
Molecular Formula:C14H22O
InChIKey:QNZVGJXBBXAWFN-XUSFDEEQSA-N
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Compound 20
Molecular Weight:268.0921
Molecular Formula:C8H13IO2
InChIKey:VJSYRMFXFUQTOH-HYXAFXHYSA-N
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Compound 9
Molecular Weight:372.4547
Molecular Formula:C22H28O5
InChIKey:FKTNHWPVYLAIRZ-YKUHUVJDSA-N
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Compound 31
Molecular Weight:240.2955
Molecular Formula:C13H20O4
InChIKey:NBQZCXGVVVEGQS-QIQIAXPXSA-N
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Compound 39
Molecular Weight:282.2891
Molecular Formula:C14H18O6
InChIKey:XFBUNTPBWDDFSP-PWMUQRGZSA-N
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Compound 26
Molecular Weight:164.032
Molecular Formula:C6H7Cl2N
InChIKey:KBHRQIXRVHFRPF-UHFFFAOYSA-M
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Compound 11
Molecular Weight:522.7138
Molecular Formula:C30H50O7
InChIKey:DHDSQOQCUGLPLH-DCASUPPBSA-N
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Compound 2
Molecular Weight:311.203
Molecular Formula:C16H16Cl2O2
InChIKey:LFHMAAFJVDIFDG-UHFFFAOYSA-N
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Compound 37
Molecular Weight:174.1944
Molecular Formula:C8H14O4
InChIKey:HFPIQGCIXRKIGK-GFCOJPQKSA-N
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Compound 40
Molecular Weight:516.7691
Molecular Formula:C33H45OPSi
InChIKey:IGTMJDDWHBHDFE-JRWLLCEYSA-N
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Compound 14
Molecular Weight:254.279
Molecular Formula:C13H18O5
InChIKey:FIGCUCSFUFOVOJ-UKNTZDJGSA-N
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Compound 25
Molecular Weight:173.62
Molecular Formula:C6H4ClNOS
InChIKey:KAFAIALSGSIJFN-UHFFFAOYSA-N
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Compound 16
Molecular Weight:469.107
Molecular Formula:C24H46CuLiO4
InChIKey:HOPWMKQEYPKLOA-OLDKPCAWSA-N
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Compound 32
Molecular Weight:302.3493
Molecular Formula:C21H19P
InChIKey:KTXDDSBSRMDZLM-UHFFFAOYSA-N
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