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Epothilones

  1. Bernd Buchmann1,
  2. Ulrich Klar2

Published Online: 15 APR 2007

DOI: 10.1002/14356007.k09_k01.pub2

Ullmann's Encyclopedia of Industrial Chemistry

Ullmann's Encyclopedia of Industrial Chemistry

How to Cite

Buchmann, B. and Klar, U. 2007. Epothilones. Ullmann's Encyclopedia of Industrial Chemistry. .

Author Information

  1. 1

    Medicinal Chemistry, Schering AG, Berlin, Germany

  2. 2

    Medicinal Chemistry, Schering AG, Berlin, Germany

Publication History

  1. Published Online: 15 APR 2007

Chemistry Terms

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Abstract

The article contains sections titled:

1.Introduction and History
2.Physical Properties
3.Syntheses
3.1.Synthesis of Epothilones A and C According to Schinzer
3.2.Synthesis of Epothilones A and C According to Danishefsky
3.3.Synthesis of Epothilones B and D According to Nicolaou
3.4.Synthesis of Epothilone D According to Danishefsky
4.Occurrence and Biosynthesis
5.Pharmacological Effects and Uses

Epothilones represent a novel class of anticancer drugs which inhibit the cell cycle by interfering with microtubules. Their chemical and pharmacological properties as well as several synthetic approaches to some of the natural compounds are described.

First results from clinical trials with natural epothilones as well as novel derivatives are promising indicating that epothilones have the potential to become a cornerstone in future cancer therapy.

Featured Compounds

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  1. 1 - 34
Compound 7
Molecular Weight:129.157
Molecular Formula:C6H11NO2
InChIKey:YBUPWRYTXGAWJX-RXMQYKEDSA-N
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Compound 20
Molecular Weight:734.231
Molecular Formula:C40H71NO5SSi2
InChIKey:HFUCXOYYSSSLMO-AHDACILMSA-N
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Compound 26
Molecular Weight:832.333
Molecular Formula:C48H73NO5SSi2
InChIKey:TUDKIYWPKCYQNY-MQVYJFAOSA-N
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Compound 22
Molecular Weight:178.2277
Molecular Formula:C11H14O2
InChIKey:XYUPRHVYEKOWCD-SNVBAGLBSA-N
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Compound 25
Molecular Weight:377.241
Molecular Formula:C13H16INO2S
InChIKey:MNJCONLUQAFTLK-ZSDISPMSSA-N
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Compound 34
Molecular Weight:693.118
Molecular Formula:C32H44Cl3NO7S
InChIKey:RDEXVVBHAOCQJA-LBAQNINDSA-N
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Compound 24
Molecular Weight:72.1057
Molecular Formula:C4H8O
InChIKey:RBACIKXCRWGCBB-SCSAIBSYSA-N
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Compound 18
Molecular Weight:300.4336
Molecular Formula:C17H32O4
InChIKey:GYXWFCNLWGDNGX-XGUBFFRZSA-N
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Compound 31
Molecular Weight:738.22
Molecular Formula:C39H71NO6SSi2
InChIKey:IDHLZOWJDYQQSB-ULCRRKNHSA-N
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Compound 3
Molecular Weight:Not Available
Molecular Formula:Not Available
InChIKey:Not Available
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Compound 19
Molecular Weight:542.9388
Molecular Formula:C29H58O5Si2
InChIKey:UHWJJPATWQNDHR-AANQFLQQSA-N
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Compound 2
Molecular Weight:188.3394
Molecular Formula:C9H20O2Si
InChIKey:WGWCJTNWUFFGFH-UHFFFAOYSA-N
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Compound 27
Molecular Weight:832.333
Molecular Formula:C48H73NO5SSi2
InChIKey:MSQZHDVNIASDTA-QWWDBQJMSA-N
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Compound 4
Molecular Weight:258.4723
Molecular Formula:C14H30O2Si
InChIKey:NERDIUMEHSWCKX-LBPRGKRZSA-N
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Compound 29
Molecular Weight:258.4723
Molecular Formula:C14H30O2Si
InChIKey:FXWDWLZZYBXICO-LBPRGKRZSA-N
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Compound 30
Molecular Weight:435.738
Molecular Formula:C24H41NO2SSi
InChIKey:DOVRGDVDVWZEME-UKJGBRIBSA-N
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Compound 12
Molecular Weight:230.4191
Molecular Formula:C12H26O2Si
InChIKey:DPQBHNZNJADHJG-UHFFFAOYSA-N
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Compound 33
Molecular Weight:401.71
Molecular Formula:C16H23Cl3O5
InChIKey:JKNFEQHNJFFSEA-TUAOUCFPSA-N
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Compound 16
Molecular Weight:327.557
Molecular Formula:C16H29NO2SSi
InChIKey:WQQIQHITWPPXOO-PABFRNLHSA-N
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Compound 9
Molecular Weight:239.3107
Molecular Formula:C13H21NO3
InChIKey:VGRIIPOCLOCJDH-LLVKDONJSA-N
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Compound 17
Molecular Weight:209.308
Molecular Formula:C11H15NOS
InChIKey:SAMXUQPRBXCGFQ-IOCXFXADSA-N
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Compound 10
Molecular Weight:126.1962
Molecular Formula:C8H14O
InChIKey:OORUMIIDKDTTNO-QMMMGPOBSA-N
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Compound 5
Molecular Weight:186.2481
Molecular Formula:C10H18O3
InChIKey:LJAMNFGOXHYQCW-QMMMGPOBSA-N
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Compound 11
Molecular Weight:145.281
Molecular Formula:C3H5BrMg
InChIKey:LFTYALBVGVNGLI-UHFFFAOYSA-M
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Compound 6
Molecular Weight:214.3013
Molecular Formula:C12H22O3
InChIKey:QGPKAFNRXHKSMT-JTQLQIEISA-N
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Compound 28
Molecular Weight:699.74
Molecular Formula:C34H43INOPSSi
InChIKey:MENRYUVKPSDDOU-NXRLRFFJSA-M
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Compound 1
Molecular Weight:Not Available
Molecular Formula:Not Available
InChIKey:Not Available
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Compound 21
Molecular Weight:706.178
Molecular Formula:C38H67NO5SSi2
InChIKey:ZIYIISFULYVYCJ-POCVSMFNSA-N
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Compound 8
Molecular Weight:146.615
Molecular Formula:C7H11ClO
InChIKey:OSCNKYWIVFHQMF-UHFFFAOYSA-N
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Compound 15
Molecular Weight:249.267
Molecular Formula:C9H16NO3PS
InChIKey:HEMJMIICMXSNBL-UHFFFAOYSA-N
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Compound 32
Molecular Weight:291.408
Molecular Formula:C16H21NO2S
InChIKey:JOXBQLMKHVTSOC-PNEZLPGLSA-N
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Compound 23
Molecular Weight:627.0568
Molecular Formula:C37H62O4Si2
InChIKey:HOHJCNDEQACQMN-WVVLTDOBSA-N
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Compound 14
Molecular Weight:346.6528
Molecular Formula:C17H38O3Si2
InChIKey:URTMHUUKKKWXRK-HNNXBMFYSA-N
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Compound 13
Molecular Weight:230.4191
Molecular Formula:C12H26O2Si
InChIKey:DPQBHNZNJADHJG-NSHDSACASA-N
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