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Epothilones

  1. Bernd Buchmann1,
  2. Ulrich Klar2

Published Online: 15 JUL 2006

DOI: 10.1002/14356007.k09_k01

Ullmann's Encyclopedia of Industrial Chemistry

Ullmann's Encyclopedia of Industrial Chemistry

How to Cite

Buchmann, B. and Klar, U. 2006. Epothilones. Ullmann's Encyclopedia of Industrial Chemistry. .

Author Information

  1. 1

    Medicinal Chemistry, Schering AG, Berlin, Germany

  2. 2

    Medicinal Chemistry, Schering AG, Berlin, Germany

Publication History

  1. Published Online: 15 JUL 2006

This is not the most recent version of the article. View current version (15 APR 2007)

Abstract

The article contains sections titled:

1.Introduction and History
2.Physical Properties
3.Syntheses
3.1.Synthesis of Epothilones A and C According to Schinzer
3.2.Synthesis of Epothilones A and C According to Danishefsky
3.3.Synthesis of Epothilones B and D According to Nicolaou
3.4.Synthesis of Epothilone D According to Danishefsky
4.Occurrence and Biosynthesis
5.Pharmacological Effects and Uses

Epothilones represent a novel class of anticancer drugs which inhibit the cell cycle by interfering with microtubules. Their chemical and pharmacological properties as well as several synthetic approaches to some of the natural compounds are described.

First results from clinical trials with natural epothilones as well as novel derivatives are promising indicating that epothilones have the potential to become a cornerstone in future cancer therapy.