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Discovery of a New Bacterial Polyketide Biosynthetic Pathway
Article first published online: 4 JAN 2001
DOI: 10.1002/1439-7633(20010105)2:1<35::AID-CBIC35>3.0.CO;2-1
© 2001 WILEY-VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany
2:1<>1.0.CO;2-R/asset/cover.gif?v=1&s=d635004284977ba098cabfbf42c3d5dc1896c648 "ChemBioChem")
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How to Cite
Moore, B. S. and Hopke, J. N. (2001), Discovery of a New Bacterial Polyketide Biosynthetic Pathway. ChemBioChem, 2: 35–38. doi: 10.1002/1439-7633(20010105)2:1<35::AID-CBIC35>3.0.CO;2-1
Publication History
- Issue published online: 4 JAN 2001
- Article first published online: 4 JAN 2001
- Abstract
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Keywords:
- biosynthesis;
- chalcone synthase;
- natural products;
- polyketides;
- transferases
Biochemically and phylogenetically unrelated to the well-characterized microbial polyketide synthases (PKSs), which are responsible for the biosynthesis of many clinically important natural products, is a new family of PKSs recently discovered in bacteria. These new enzymes, termed type III PKSs, may be the predecessors to the plant PKSs, and their study promises insights into a new condensing reaction towards small aromatic metabolites in bacteria (see scheme).