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Short Communication
A Mechanism of Benzoic Acid Biosynthesis in Plants and Bacteria that Mirrors Fatty Acid β-Oxidation
Article first published online: 28 SEP 2001
DOI: 10.1002/1439-7633(20011001)2:10<784::AID-CBIC784>3.0.CO;2-K
© 2001 WILEY-VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany
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Additional Information
How to Cite
Hertweck, C., Jarvis, A. P., Xiang, L., Moore, B. S. and Oldham, N. J. (2001), A Mechanism of Benzoic Acid Biosynthesis in Plants and Bacteria that Mirrors Fatty Acid β-Oxidation. ChemBioChem, 2: 784–786. doi: 10.1002/1439-7633(20011001)2:10<784::AID-CBIC784>3.0.CO;2-K
Publication History
- Issue published online: 28 SEP 2001
- Article first published online: 28 SEP 2001
- Manuscript Revised: 23 MAY 2001
- Manuscript Received: 3 APR 2001
- Abstract
- Article
- References
- Cited By
Keywords:
- biosynthesis;
- enoyl-CoA hydratase;
- isotopic labeling;
- polyketides;
- salicylic acid
Graphical Abstract
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Despite the simple structure and widespread occurrence of benzoic acid, its biosynthesis has resisted complete elucidation. However, recent studies reveal that the conversion of cinnamoyl-CoA into benzoyl-CoA (see scheme; R=Ph) can proceed by a route that resembles fatty acid β-oxidation. Feeding studies and sequence analyses show that both pathways not only proceed with the same stereochemistry, but are also mechanistically related.