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Keywords:

  • cell cycle control;
  • cyclin dependent kinases;
  • mitosis;
  • Nobel lecture
Thumbnail image of graphical abstract

Wee mutants in fission yeast (see picture) are just one part in the story of how the mechanism that controls cell division in most living organisms was determined. A wide range of techniques were used to provide evidence for the universality of cell cycle controls regulating the onset of mitosis in eukaryotes. This review focusses on cyclin dependent kinases, the major regulators of the eukaryotic cell cycle.