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Amodiaquine for treating malaria

  1. Piero L Olliaro1,*,
  2. Paola Mussano2

Editorial Group: Cochrane Infectious Diseases Group

Published Online: 7 OCT 2009

Assessed as up-to-date: 3 FEB 2003

DOI: 10.1002/14651858.CD000016

Database Title

Additional Information

How to Cite

Olliaro PL, Mussano P. Amodiaquine for treating malaria. Cochrane Database of Systematic Reviews 2003, Issue 2. Art. No.: CD000016. DOI: 10.1002/14651858.CD000016.

Author Information

  1. 1

    World Health Organization, UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR), Geneva, Switzerland

  2. 2

    Genthod, Switzerland

*Piero L Olliaro, UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR), World Health Organization, 1211 Geneva 27, Geneva, Switzerland. olliarop@who.int.

Publication History

  1. Publication Status: Stable (no update expected for reasons given in 'What's new')
  2. Published Online: 7 OCT 2009

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Brazil 1983-84 {published data only}
  • Costas Passo AD, Osanai CH, Reyes S. [Resistênciain vivo do Plasmodium falciparum as 4-aminoquinoleìnas e à associacao sulfadoxina-pirimetamina. II-estudio de Imperatriz, Maranhao, 1983-1984]. Revista Societade Brasileira de Medicina Tropical 1987;20(2):109-13.
Burkina Faso 1998 {published data only}
  • Brasseur P, Guiguemde R, Diallo S, Guiyedi V, Kombila M, Ringwald P, Olliaro P. Amodiaquine remains effective for treating uncomplicated malaria in West and Central Africa. Transactions of the Royal Society of Tropical Medicine and Hygiene 1999;93:645-50.
Cameroon 1998 {published data only}
  • Brasseur P, Guiguemde R, Diallo S, Guiyedi V, Kombila M, Ringwald P, et al. Amodiaquine remains effective for treating uncomplicated malaria in West and Central Africa. Transactions of the Royal Society of Tropical Medicine and Hygiene 1999;93:645-50.
Cameroon-Bangangte92 {unpublished data only}
  • Brasseur P, Agnamey P, Same Ekobo A, Samba G, Favennec L, Kouamouo J. Interest of amodiaquine for the treatment of Plasmodium falciparum malaria in West and Central Africa [Interet de l'amodiaquine pour le traitement du paludisme a Plasmodium falciparum en Afrique de l'ouest et du centre].
Cameroon-Centre 1994 {published data only}
  • Chambon R, Louis FJ, Lescieux A, Ringwald P, Nyolo B, Mooh E, et al. Sensibilité in vivo aux amino-4-quinoléines des isolats de Plasmodium falciparum à Yaounde, département du Mfoundi province du Centre, Cameroun [In vivo sensitivity to 4-aminoquinolines of Plasmodium falciparum isolates in Yaounde, department of Mfoundi, Central province, Cameroon] Document Technique No878/OCEAC/LRP. OCEAC, 21 July 1994.
Cameroon-East 1993 {published data only}
  • Louis FJ, Chambon R, Ringwald P, Mvondo JL, Kote A, Nyolo B, et al. Sensibilité in vivo aux amino-4-quinoléines des isolats de Plasmodium falciparum à Batouri, département de la Kadey, province de l'Est, Cameroun [In vivo sensitivity to 4-aminoquinolines of Plasmodium falciparum isolates in Batouri, department of Kadey, East province, Cameroon] Document Technique No867/OCEAC/BIO. OCEAC, 4 February 1994.
Cameroon-Hevécam88-9 {published data only}
  • Gazin P, Louis JP, Hengy C, Foumane V. Etude de la sensibilité de Plasmodium falciparum à la chloroquine et à l'amodiaquine chez les enfants d'Hevecam-Niété [Study of the sensitivity of Plasmodium falciparum to chloroquine and amodiaquine in children in Hevecam-Niete] OCEAC/SG/SEM/LAB. OCEAC, April 1989.
Cameroon-Hévécam2001 {published data only}
  • Basco L, Same-Ekobo A, Ngane VF, Ndounga M, Metoh T, Ringwald P, et al. Therapeutic efficacy of sulfadoxine/pyrimethamine, amodiaquine and sulfadoxine/pyrimethamine-amodiaquine combinations for the treatment of uncomplicated Plasmodium falciparum malaria in young children in Cameroun.
Cameroon-Kumba1992 {unpublished data only}
  • Brasseur P, Agnamey P, Same Ekobo A, Samba, Favennec L, Kouamouo J. Interest of amodiaquine for the treatment of Plasmodium falciparum malaria in West and Central Africa [Interet de l'amodiaquine pour le traitement du paludisme a Plasmodium falciparum en Afrique de l'ouest et du centre].
Cameroon-South 1988 {published data only}
  • Hengy C, Eberle F, Arrive A, Kouka-Bemba D, Gazin P, Jambou R. Uncomplicated malaria in an area of high-level chloroquine resistance [Acces palustres simples en zone de haut niveau de résistance à la chloroquine]. Bulletin de la Societe de Pathologie Exotique 1990;83:53-60.
Cameroon-South 1994a {published data only}
  • Chambon R, Louis FJ, Lescieux A, Foumane V, Nyolo B, Ringwald P. Surveillance de la résistance aux amino-4-quinoléines: test in vivo en milieu scolaire district de Sangmelima, département du Dja et Lobo province du Sud, Republique du Cameroun [Surveillance of resistance to 4-aminoquinoleines: in vivo test in school-age children in the district of Sangmelima, department of Dja and Lobo, South province, Cameroon] Document Technique No870/OCEAC/DSP. OCEAC, 15 April 1994.
Cameroon-South 1994b {published data only}
  • Le Hesran J-Y, Boudin C, Cot M, Personne P, Chambon R, Foumane V, et al. In vivo resistance of Plasmodium falciparum to chloroquine and amodiaquine in South Cameroon and age-related efficacy of drugs. Annals of Tropical Medicine and Parasitology 1997;91(6):661-4.
Cameroon-Yaounde 92 {unpublished data only}
  • Brasseur P, Agnamey P, Same Ekobo A, Samba G, Favennec L, Kouamouo J. Interest of amodiaquine for the treatment of Plasmodium falciparum malaria in West and Central Africa [Interet de l'amodiaquine pour le traitement du paludisme a Plasmodium falciparum en Afrique de l'ouest et du centre].
Cameroon-Yaounde97-9 {published data only}
  • Ringwald P, Keundijian A, Same Ekobo A, Basco LK. Chemoresistance of Plasmodium falciparum in the urban region of Yaounde, Cameroon. Part 2: Evaluation of efficacy of amodiaquine and the sulfadoxine-pyrimethamine combination in the treatment of uncomplicated P. falciparum malaria in Yaounde, Cameroon [Chimiorésistance de P. falciparum en milieu urbain à Yaoundé, Cameroun. Part 2: Evaluation de l'efficacité de l'amodiaquine et de l'association sulfadoxine/pyriméthamine pour le traitement de l'accès palustre simple à Plasmodium falciparum à Yaoundé, Cameroun]. Tropical Medicine and International Health 2000;5(9):620-7.
    Direct Link:
China 1986 {published data only}
  • Quilin H, Weichuan O, Jiexian Z, Zhu W, Kunyan Z, Jiankang H, et al. Effectiveness of amodiaquine, sulfadoxine-pyrimethamine, and combinations of these drugs for treating chloroquine-resistant falciparum malaria in Hainan Island, China. Bulletin of the World Health Organization 1988;66(3):353-8.
Colombia-Antioquia98 {published data only}
  • Blair S, Lacharme LL, Carmona-Fonseca J, Tobon A. Resistance of Plasmodium falciparum to three antimalarial drugs in Turbo (Antioquia, Colombia), 1998 [Resistencia de Plasmodium falciparum a tres f'àrmacos antimalàricos en Turbo (Antioquia, Colombia), 1998]. Revista Panamericana de Salud Publica - Pan American Journal of Public Health 2001;9(1):23-9.
Congo 1992 {unpublished data only}
  • Brasseur P, Agnamey P, Same Ekobo A, Samba G, Favennec L, Kouamouo J. Interest of amodiaquine for the treatment of Plasmodium falciparum malaria in West and Central Africa [Interet de l'amodiaquine pour le traitement du paludisme a Plasmodium falciparum en Afrique de l'ouest et du centre].
Congo-Brazzaville 86 {published data only}
  • Carme B, Mbitsi A, Moudzeo H, Ndinga M, Eozenou P. Drug resistance of Plasmodium falciparum in Congo. 2. In vivo comparative study of chloroquine and amodiaquine inshool-age children in Brazzaville llois (November 1986) [Chimio-résistance de Plasmodium falciparum au Congo. 2. Etude comparative in vivo de la chloroquine et de l'amodiaquine chez des écoliers brazzavillois (Novembre 1986)]. Bulletin de la Societe de Pathologie Exotique 1987;80:426-33.
Congo-Brazzaville90 {published data only}
  • Carme B, Sathounkasi C, Mbitsi A, Ndounga M, Gay F, Chandenier J, et al. Comparative efficacy of chloroquine and amodiaquine (25 and 35 mg/kg) in P. falciparum-infected school-age children (Brazzaville, March 1990) [Efficacité comparée de la chloroquine et de l'amodiaquine (25 et 35 mg/kg) chez des écoliers porteurs de P. falciparum (Brazzaville, Mars 1990).]. Bulletin de la Societe de Pathologie Exotique 1991;84:77-9.
Congo-P Noire 1986 {published data only}
  • Simon F, Porte J, Verdier F, Guigon D, Drouville C, Le Bras J. Sensitivity of malaria in children of Pointe-Noire, Congo, first semester 1986 [Chimiosensibilité du paludisme dans une population d'enfants de Pointe-Noire, Congo, au premier semestre 1986.]. Bulletin de la Societe de Pathologie Exotique 987;80:417-25.
Cote d'Ivoire 1993 {published data only}
  • Penali LK, Assi-Coulibaly L, Kaptue B, Konan D. Parasitological and clinical response to amodiaquine vs chloroquine in the treatment of uncomplicated Plasmodium falciparum malaria in children in endemic areas [Responses parasitologiques et cliniques de l'amodiaquine vs chloroquine dans le traitment de l'acces palustre simple a Plasmodium falciparum chez l'infant en zone d'endemie]. Bulletin de la Societe de Pathologie Exotique 1994;87:244-7.
Equatorial Guinea 91 {published data only}
  • Roche J, Benito A, Ayecaba S, Amela C, Molina R, Alvar J. Resistance of Plasmodium falciparum to antimalarial drugs in Equatorial Guinea. Annals of Tropical Medicine and Parasitology 1993;87(5):443-9.
Gabon 1997-8 {published data only}
  • Guiyedi V, Koko J, Akotet MB, Manfoumbi MM, Matségui PB, Traoré B, et al. Evaluation of the efficacy and tolerance of amodiaquine versus chloroquine in the treatment of uncomplicated malaria in children in Gabon [Evaluation de l'efficacité et de la tolérance de l'amodiaquine versus chloroquine dans le traitement de l'accès palustre simple chez l'enfant au Gabon]. Bulletin de la Societe de Pathologie Exotique 2001;94(3):253-7.
Gabon-Libreville 98 {published data only}
  • Brasseur P, Guiguemde R, Diallo S, Guiyedi V, Kombila M, Ringwald P, et al. Amodiaquine remains effective for treating uncomplicated malaria in West and Central Africa. Transactions of the Royal Society of Tropical Medicine and Hygiene 1999;93:645-50.
Gambia 1994 {published data only}
  • Muller O, Boele van Hensbroek M, Jaffar S, Drakeley C, Okorie C, Joof D, et al. A randomised trial of chloroquine, amodiaquine, and pyrimethamine-sulfadoxine in Gambian children with uncomplicated malaria. Tropical Medicine and International Health 1996;1(1):124-32.
    Direct Link:
Kenya 1989 {published data only}
  • Nevill CG, Verhoeff FH, Munafu CG, Ten Hove WR, Van der Kaay HJ, Were JBO. A comparison of amodiaquine and chloroquine in the treatment therapy of falciparum malaria in Kenya. East African Medical Journal 1994;71(3):167-70.
  • Nevill CG, Verhoeff FH, Munafu CG, Ten Hove WR, Van Der Kaay HJ, Were JBO. Role of amodiaquine in the treatment of falciparum malaria in East Africa [Place de l'amodiaquine dans le traitement du Paludisme a P. falciparum en Afrique de l'Est.]. Medecine d'Afrique Noire 1992;39(10):4-8.
Kenya-Eldoret 1994 {published data only}
  • Anabwani GM, Esamai FO, Menya DA. A randomised controlled trial to assess the relative efficacy of chloroquine, amodiaquine, halofantrine and Fansidar (R) in the treatment of uncomplicated malaria in children. East African Medical Journal 1996;73(3):155-8.
Kenya-Entosopia 91 {unpublished data only}
  • Nevill C, Munafu CM, Khan B, Muller A, GACHIHI G. Amodiaquine not pyrimethamine/sulfadoxine should replace chloroquine for the primary treatment of non-severe P. falciparum malaria in Kenya. African Medical & Research Foundation. Kenya: Nairobi.
Kenya-Entosopia 94 {unpublished data only}
  • Nevill C.
Kenya-Kibwezi 1997 {published data only}
  • Gorissen E, Ashruf G, Lamboo M, Bennebroek J, Gikunda S, Mbaruku G, et al. In vivo efficacy study of amodiaquine and sulfadoxine/pyrimethamine in Kibwezi, Kenya and Kigoma, Tanzania. Tropical Medicine and International Health 2000;5(6):459-63.
    Direct Link:
Kenya-Kilifi 1993 {unpublished data only}
  • Nevill C.
Kenya-Malindi 1984 {published data only}
  • Watkins WM, Sixsmith DG, Spencer HC, Boriga DA, Kariuki DM, Kipingor T. Effectiveness of amodiaquine as treatment for chloroquine-resistant Plasmodium falciparum infections in Kenya. Lancet 1984;1(8387):357-9.
Kenya-Malla 1994 {unpublished data only}
  • Nevill C.
Kenya-Migori 1990 {unpublished data only}
  • Nevill C, Munafu CM, Khan B, Muller A, CACHATI G. Amodiaquine not pyrimethamine/sulfadoxine should replace chloroquine for the primary treatment of non-severe P. falciparum malaria in Kenya. African Medical & Research Foundation. Kenya: Nairobi.
Kenya-Mombasa 90 {published data only}
  • Hagos B, Khan B, Ofulla AVO, Kariuki D, Martin SK. Response of falciparum malaria to chloroquine and three second line antimalarial drugs in a Kenyan coastal school age population. East African Medical Journal 1993;70(10):620-3.
Kenya-Nangina 1993 {unpublished data only}
  • Nevill C.
Kenya-Ortum 1991 {unpublished data only}
  • Nevill C, Munafu CM, Khan B, Muller A, CACHATI G. Amodiaquine not pyrimethamine/sulfadoxine should replace chloroquine for the primary treatment of non-severe P. falciparum malaria in Kenya. African Medical & Research Foundation. Kenya: Nairobi.
Kenya-Sololo 1993 {unpublished data only}
  • Nevill C.
Kenya-Taveta 1994 {unpublished data only}
  • Nevill C.
Kenya-Turiani 1991 {unpublished data only}
  • Nevill C, Munafu CM, Khan B, Muller A, CACHATI G. Amodiaquine not pyrimethamine/sulfadoxine should replace chloroquine for the primary treatment of non-severe P. falciparum malaria in Kenya. African Medical & Research Foundation. Kenya: Nairobi.
Kenya-Turiani 1992 {unpublished data only}
  • Nevill C, Munafu CM, Khan B, Muller A, CACHATI G. Amodiaquine not pyrimethamine/sulfadoxine should replace chloroquine for the primary treatment of non-severe P. falciparum malaria in Kenya. African Medical & Research Foundation. Kenya: Nairobi.
Kenya-West 1987 {published data only}
  • Keuter M, Sanders J, Ronday M, veltkamp S, Kamsteeg H, Schouten E, et al. Parasitological, clinical and haematological response of children with Plasmodium falciparum to 4-aminoquinolines and to pyrimethamine-sulfadoxine with quinine in western Kenya. Tropical and Geographical Medicine 1992;44:1-8.
Madagascar 1983-4 {published data only}
  • Ramanamirija JA, Deloron P, Biaud JM, Le Bras J, Coulanges P. In vitro and in vivo sensitivity to aux 4-aminoquinolines of Plasmodium falciparum in Madagascar: results of a two-year study [Sensibilité in vitro et in vivo aux amino-4-quinoléines de Plasmodium falciparum à Madagascar: résultats de deux années d'étude]. Bulletin de la Societe de Pathologie Exotique 1985;75:606-14.
Madagascar 1985-6 {published data only}
  • Marchais H, Ramanamirija JA, Le Bras J, Coulange P. In vivo and in vitro sensitivity to 4-aminoquinolines of Plasmodium falciparum in Madagascar: results of a study conducted on the East coast (July 1985-July 1986) [Sensibilité in vivo et in vitro aux amino-4-quinoléines de Plasmodium falciparum à Madagascar: résultats d'une étude effectuée sur la côte Est (Juillet 1985-Juillet 1986)]. Archives de l'Institute Pasteur de Madagascar 1987;53(1):43-62.
Malawi 1985 {published data only}
  • Heymann DL, Khoromana CO, Wirima JJ, Campbell CC. Comparative efficacy of alternative therapies for plasmodium falciparum infections in Malawi. Transactions of the Royal Society of Tropical Medicine and Hygiene 1987;81:722-4.
Mozambique 1986 {published data only}
  • Schapira A, Schwalbach J. Evaluation of four therapeutic regimens for falciparum malaria in Mozambique 1986. Bulletin of the World Health Organization 1988;66(2):219-26.
Nigeria-Ibadan 1984 {published data only}
  • Walker O, Salako LA, Patience O, Obih O, Bademose K, Sodeinde O. The sensitivity of Plasmodium falciparum to chloroquine and amodiaquine in Ibadan, Nigeria. Transactions of the Royal Society of Tropical Medicine and Hygiene 1984;78:782-4.
Nigeria-Ibadan 1990 {published data only}
  • Sowunmi A, Salako LA. Evaluation of the relative efficacy of various antimalarial drugs in Nigerian children under five years of age suffering from acute uncomlicated falciparum malaria. Annals of Tropical Medicine and Parasitology 1992;86(1):1-8.
Nigeria-Ibadan 2000 {published data only}
  • Sowunmi A, Ayede AI, Falade AG, Ndikum VN, Sowunmi CO, Adedeji AS, et al. Randomized comparison of chloroquine and amodiaquine in the treatment of acute, uncomplicated, Plasmodium falciparum malaria in children. Annals of Tropical Medicine and Parasitology 2001;95(6):549-58.
Philippines 1984-5 {published data only}
  • Watt G, Long G, Padre L, Alban P, Sangalang R, Ranoa C, et al. Amodiaquine less effective than chloroquine in the treatment of falciparum malaria in the Philippines. American Journal of Tropical Medicine and Hygiene 1987;36(1):3-8.
Senegal-Dakar 1996-8 {published data only}
  • Brasseur P, Guiguemde R, Diallo S, Guiyedi V, Kombila M, Ringwald P, et al. Amodiaquine remains effective for treating uncomplicated malaria in West and Central Africa. Transactions of the Royal Society of Tropical Medicine and Hygiene 1999;93:645-50.
Senegal-Mlomp 1996-8 {published data only}
  • Brasseur P, Guiguemde R, Diallo S, Guiyedi V, Kombila M, Ringwald P, et al. Amodiaquine remains effective for treating uncomplicated malaria in West and Central Africa. Transactions of the Royal Society of Tropical Medicine and Hygiene 1999;93:645-50.
Sénégal-Diohine 1996 {published data only}
  • Sokhna CS, Trape J-F, Robert V. Gametocytaemia in Senegalese children with uncomplicated falciparum malaria treated with chloroquine, amodiaquine or sulfadoxine+pyrimethamine. Parasite 2001;8:243-50.
Tanzania-Centre 1988 {published data only}
  • Irare SGM, Lemnge MMM, Mhina JIK. Falciparum malaria fully cleared by amodiaquine, pyrimethamine-sulfadoxine and pyrimethamine-sulfalene in areas of chloroquine resistance in Dodoma, Tanzania. Tropical and Geographical Medicine 1991;43:352-6.
Tanzania-Kigoma 1997 {published data only}
  • Gorissen E, Ashruf G, Lamboo M, Bennebroek J, Gikunda S, Mbaruku G, et al. In vivo efficacy study of amodiaquine and sulfadoxine/pyrimethamine in Kibwezi, Kenya and Kigoma. Tropical Medicine and International Health 2000;5(6):459-63.
    Direct Link:
Uganda-Kampala 1999 {published data only}
  • Staedke SG, Kamya MR, Dorsey G, Gasasira A, Ndeezi G, Charlebois ED, et al. Amodiaquine, sulfadoxine/pyrimethamine, and combination therapy for treatment of uncomplicated falciparum malaria in Kampala, Uganda: a randomised trial. Lancet 2001;358:368-74.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Africa 1999 {published data only}
  • Mengesha T, Makonen E. Comparative efficacy and safety of chloroquine and alternative antimalarial drugs: a meta-analysis from six African countries. East African Medical Journal 1999;76(6):314-9.
AfricaMadagascar83-6 {published data only}
  • Le Bras J, Simon F, Ramanamirija JA, Calmel MB, Hatin I, Deloron P, et al. Sensitivity of Plasmodium falciparum to quinolines and therapeutic strategies: comparison of the situation in Africa and Madagascar between 1983 and 1986 [Sensibilite de Plasmodium falciparum aux quinoleines et strategies therapeutiques: comparaison de la situation en Afrique et Madagascar entre 1983 et 1986]. Bulletin de la Societe de Pathologie Exotique 1987;80:477-89.
Benin-Cotonou 1989 {published data only}
  • Raccurt CP, Arouko H, Djossou F, Macaigne F, Massougbodji A, Zohoun T, et al. In vivo amodiaquine sensitivity of Plasmodium falciparum in the town of Cotonou and in the vicinity (Benin) [Sensibilite in vivo du Plasmodium falciparum a l'amodiaquine dans la ville de Cotonou et ses environs (Benin)]. Medicine Tropicale 1990;50(1):21-6.
Cameroon 1987-90 {published data only}
  • Louis FJ, Louis JP, Fadat G, Maubert B, Hengy C, Trebucq A. [Interet de l'amodiaquine dans le traitement des acces palustres simples a Plasmodium falciparum en zone de chloroquino resistance]. Bull liais doc OCEAC 1992;100:14-6.
Cameroon 1990a {published data only}
  • Fadat G, Hengy C, Louis JP, Trebucq A, Louis FJ, Gelas H. [L'amodiaquine, une therapeutique rehabiliter dans le traitement des acces palustres en zone de chimioresistance de Plasmodium falciparum]. Bull liais doc OCEAC 1991;95:41-3.
Cameroon 1990b {published data only}
Cameroon 1993-4 {published data only}
  • Louis FJ, Bickii J, Lescieux A, Chambon R, Louis-Lutinier D, Ringwald P. Increase of the in vivo sensitivity of Plasmodium falciparum to 4-aminoquinolines in Cameroon in 1993-1994. Liverpool: BSP, September 1994.
  • Louis FJ, Foumane V, Bickii J, Lescieux A, Chambon R, Gelas H, et al. [Sensibilite in vivo a l'amodiaquine de Plasmodium falciparum au Cameroun en 1993-1994]. Bull liais doc OCEAC 1994;27(3):119-20.
Cameroon 1996 {published data only}
  • Chambon R, Lemardeley P, Boudin C, Ringwald P, Chandenier J. Surveillance of the in vivo sensitivity of Plasmodium falciparum to antimalarial drugs: preliminary results of the OCEAC malaria network [Surveillance de la sensibilité in vivo de Plasmodium falciparum aux anti-malariques: résultat des premiers tests du réseau paludisme OCEAC]. Medecine Tropicale 1997;57:357-60.
Cameroon 1999 {published data only}
  • Laboratoire de Santé Publique, OCEAC. Studies of therapeutic efficacy of antimalarial drugs of common use in Cameroon [Etudes d'efficacités thérapeutiques des antipaludiques d'utilisation courante au Cameroun]. Bull liais doc OCEAC 1999;32(4):43-4.
Cameroon 2000 {published data only}
  • Soula G, Ndounga M, Foumane V, Ollivier G, Youmba JC, Basco L, et al. Status of resistance of Plasmodium falciparum to chloroquine in Cameroon and alternative treatments [Bilan de la résistance de Plasmodium falciparum à la chloroquine au Cameroun et alternatives thérapeutiques]. Bull liais doc OCEAC 2000;33(4):13-22.
Cameroon-Bafoussam00 {unpublished data only}
  • Foumane V, Youomba JC, Ndounga M, Soula G, Samé-Ekobo A. Evaluation de l'efficacité thérapeutique de la chloroquine et de l'amodiaquine chez les enfoants âgés de 6 mois à 5 ans dans le traitement du paludisme à Plasmodium falciparum non compliqué à Eséka (Cameroun) Document technique No 1 100 OCEAC/LSP/2000. OCEAC, 2000.
Cameroon-Edea 1987 {published data only}
  • Macaigne F, Combe A, Vincendeau P, Eboumbou E, Garnier T, Michel R, et al. In vivo sensitivity of Plasmodium falciparum to amodiaquine in the town of Edea (Cameroon) [Sensibilite in vivo de Plasmodium falciparum l'amodiaquine dans la ville d'Edea (Cameroun)]. Bulletin de la Societe de Pathologie Exotique 1989;82:208-16.
Cameroon-Eséka 1999 {published data only}
  • Soula G, Foumane F, Ollivier G, Ndounga M, Ringwald P, Munga J, et al. Evaluation de l'efficacité thérapeutique de la chloroquine et de l'amodiaquine chez les enfoants âgés de 6 mois à 5 ans dans le traitement du paludisme à Plasmodium falciparum non compliqué à Eséka (Cameroun). Document Technique No 1069 OCEAC/LSP/1999. OCEAC, 1999.
Cameroon-Mengang1999 {published data only}
  • Njokou M, Youbi J, Boudin C. Sensitivity, gametocytogenesis and infectivity to Anopheles gambiae following treatment of Plasmodium falciparum isolates with chloroquine, amodiaquine and sulfadoxine-pyrimethamine [Sensibilité, gametocytogénèse et infectivité pour Anopheles gambiae après traitment des souches de Plasmodium falciparum à la chloroquine, à l'amodiaquine et à la sulfadoxine-pyriméthamine]. Bull liais doc OCEAC 1999;32(2):46-52.
Cameroon-Nlongkak 99 {unpublished data only}
  • Ollivier G, Ndounga M, Obatte Zo'o J, Ringwald P, Foumane F, Samé-Ekobo A. [Evaluation de l'efficacité thérapeutique de l'amodiaquine chez les enfants de 6 mois à 5 ans pour le traitement du paludisme à Plasmodium falciparum non compliqué dans le centre de santé intégré de Nlongkak (CSI catholique)]. OCEAC.
Cameroon-S Est 1993 {unpublished data only}
  • Rouet F, Ringwald P, Foumane V, Nyolo B, Chambon R, Louis FJ. Sensibilite in vivo aux amino-4-quinoleines des souches de Plasmodium falciparum a Limbe. Document Technique No 855/OCEAC/BIO. OCEAC, 30 September 1993.
Cameroon-S West 1989 {published data only}
  • Gazin P, Louis JP, Mulder L, Eberl‚ F, Jambou R, Moyroud, et al. Evaluation of Plasmodium falciparum susceptibility to chloroquine and amodiaquine using a simplified, in vivo, 7-day test in southern Cameroon [Evaluation par test simplifie in vivo de la chimiosensibilite du Plasmodium falciparum la chloroquine et l'amodiaquine dans le sud du Cameroun]. Medecine Tropicale 1990;50(1):27-31.
Cameroon-South 1993 {unpublished data only}
  • Louis FJ, Ringwald P, Rouet F, Foumane V, Nyolo B. Sensibilite in vivo aux amino-4-quinoleines des souches de Plasmodium falciparum dans le canton Bulu du Dja. Document Technique No 849/OCEAC/BIO. OCEAC, 27 July 1993.
Cameroon-Urban 1990 {published data only}
  • Hengy C, Gazin P, Eberle F, Jambou R, Louis JP. Evaluation of the efficacy of amino-4-quinolones in a chemoresistant zone. Proposals for new therapeutic schemes. Medicine Tropicale 1990;50(1):109-11.
Cameroon-Yaounde 96 {published data only}
  • Chambon R, Lemardeley P, Boudin C, Ringwald P, Chandenier J. Surveillance of in vivo susceptibility of Plasmodium falciparum to antimalarious drugs: results of preliminary studies of the OCEAC malaria network [Surveillance de la sensibilité in vivo de Plasmodium falciparum aux anti-malariques: résultats des premiers tests du réseau paludisme OCEAC]. Medicine Tropicale 1997;57:357-60.
Cameroon-Yaounde1988 {published data only}
  • Ghogomu NA, Mfonfu D, Ngnintendem B. [Etude de chloroquinoresistance chez des enfants de 3-10 ans dans les Scoles primaires et maternelles de la ville de Yaounde]. Premieres assises internationales sur le paludisme en Afrique; 1988 mai 31-juin 4; Yaounde, Cameroun: 49-50.
Cameroon-Yaounde87-8 {published data only}
  • Hengy C, Garrigue G, Abissegue B, Ghogomu NA, Gazin P, Gelas H, et al. [Surveillance de la chimiosensibilite de Plasmodium falciparum e Yaounde et ses environs (Cameroun). Etude in vivo, in vitro]. Bulletin de la Societe de Pathologie Exotique 1989;82:217-23.
Congo 1985-9 {published data only}
  • Carme B, Moudzeo H, Mbitsi A, Sathounkazi C, Ndounga M, Brandicourt O, et al. Plasmodium falciparum drug resistance in the Congo. Evaluation of surveys carried out from 1985 to 1989 [La resistance medicamenteuse de Plasmodium falciparum au Congo. Bilan des enquetes realisees de 1985 a 1989]. Bulletin de la Societe de Pathologie Exotique 1990;83(2):228-41.
Congo 1986-90 {published data only}
  • Carme B, Moudzeo H, Mbitsi A, Ndounga M, Samba G. Stabilization of drug resistance (chloroquine and amodiaquine) of Plasmodium falciparum in semiimmune populations in the Congo. Journal of Infectious Diseases 1991;164:437.
Cote d'Ivoire 1990 {unpublished data only}
  • Kone M, Penali LK, Brou-aka N, Cuhon J, Kassi, Abrogoua DD, et al. [Sensibilite in vivo du Plasmodium falciparum a l'amodiaquine dans la ville de Cotonou et ses environs (Benin)].
Cote d'Ivoire 1995 {published data only}
  • Adou-Bryn KD, Kouassi D, Ouhon J, Assoumou A, Kone M. Clinical trial of amodiaquine in the commune of Attécoubé (Abidjan, Côte d'Ivoire) (May-December 1995) [Essai clinique de l'amodiaquine dans la commune d'Attécoubé (Abidjan, Côte d'Ivoire) (mai-décembre 1995)]. Bulletin de la Societe de Pathologie Exotique 2000;93(2):115-8.
Gabon 1995 {published data only}
India 1952 {published data only}
  • Singh I, Kalyanum TS. The superiority of "camoquin" over other antimalarials. British Medical Journal 1952;312-5.
India 1989-90 {published data only}
  • Pandya AP, Barkakaty BN, Narasimham MVVL. Comparative efficacy of chloroquine and amodiaquine in Plasmodium falciparum strain of North-Eastern India. The Journal of Communicable Diseases 1994;26(2):61-7.
India 1989-92 {published data only}
  • Misra SP, Nandi J, Lal S. Chloroquine versus amodiaquine in the treatment of Plasmodium falciparum malaria in northeast India. The Indian Journal of Medical Research 1995;102:119-23.
Kenya 1993 {published data only}
  • van Dillen J, Custers M, Wensink A, Wouters B, van Voorthuizen T, Voorn W, et al. A comparison of amodiaquine and sulfadoxine-pyrimethamineas first-line treatment of falciparum malaria in Kenya. Transactions of the Royal Society of Tropical Medicine and Hygiene 1999;93:185-8.
Kenya 1998 {published data only}
  • Rapuoda JH, Otieno JA, Omar S. Status of anti-malarial drugs sensitivity in Kenya. Malaria and infectious diseases in Africa. Vol. 8, 1998:25-43.
Liberia 2000-01 {published data only}
  • Checchi F, et al. An in vivo study of the efficacy of chloroquine, sulfadoxine/pyrimethamine and amodiaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Harper, maryland County, Liberia. Epicentre-MSF report 2001.
Madagascar 1983a {published data only}
  • Deloron P, Le Bras J. Plasmodium falciparum in Madagascar: in vivo and in vitro sensitivity to seven drugs. Annals of Tropical Medicine and Parasitology 1985;79(4):357-65.
Madagascar 1983b {published data only}
  • Deloron P, Ramanamirija JA, Le Bras J, Coulanges P. 4-Aminoquinoline-sensitivity of Plasmodium falciparum in Madagascar: III. Studies in three regions of the interior [Sensibilite aux amino-4-quinoleines de Plasmodium falciparum a Madagascar: III etudes en trois regions de l'interieur]. Archives de l'Institut Pasteur de Madagascar 1984;51(1):57-68.
Madagascar 1983c {published data only}
  • Delorn P, Le Bras J, Rammanamirija JA. Amodiaquine and chloroquine efficacy against Plasmodium falciparum in Madagascar. Lancet 1984;1:1303-4.
Pakistan 1997 {published data only}
  • Iqbal S, Nishtar T, Hayat Z, Rehman S. Review of 100 cases of falciprum malaria. Journal of the College of Physicians and Surgeons Pakistan 1997;8(3):114-6.
PapuaNewGuinea 1989 {published data only}
  • Schuurkamp GJ, Kereu RK. Resistance of Plasmodium falciparum to chemoterapy with 4-aminoquinolines in the Ok Tedi area of Papua New Guinea. Papua and New Guinea Medical Journal 1989;32(1):33-4.
PapuaNewGuinea 1991 {published data only}
  • Sapak P, Garner P, Baea M, Narara A, Heywood P, Alpers M. Ineffectiveness of amodiaquine against Plasmodium falciparum malaria in symptomatic young children living in an endemic malarious area of Papua New Guinea. Journal of Tropical Pediatrics 1991;37(4):185-90.
RCA 1984-6 {published data only}
  • Desfontaine M. [Chimio-resistance de Plasmodium falciparum aux amino-4-quinoleines en Afrique Centrale: V - Chloroquino-resistance en RCA]. Bulletin de liaison et de documentation - Organisation pour la lutte contre les endemies en Afrique Central. Yaounde: Organisation de Coordiation Pour La Lutte Contre Les Endemies en Afrique Centrale, 1990:28-36.
Rwanda 1986 {published data only}
  • Deloron P, Sexton JD, Bugilimfura L, Sezibera C. Amodiaquine and sulfadoxine-pyrimethamine as treatment for chloroquine-resistant Plasmodium falciparum in Rwanda. American Journal of Tropical Medicine and Hygiene 1988;38(2):244-8.
Sénégal 1997 {published data only}
  • Faye O. The therapeutic efficacy of amodiaquine, sulfadoxine-pyrimethamine combination and quinine in Senegal. Paludisme et maladies infectieuses en Afrique 1999;10:25-7.
Tanzania 1988 {published data only}
  • Mutabingwa TK, Malle LN, De Geus A, Wernsdorfer WH. Malaria in infants whose mothers received chemoprophylaxis: response to amodiaquine therapy. Tropical and Geograhical Medicine 1992;44:293-8.
Uganda 1988 {published data only}
  • Nevill CG, Ochen K, Munafu CG, Bekobita D, Sezi CL. Response of Plasmodium falciparum to chloroquine and Fansidar (R) in vivo and chloroquine and amodiaquine in vitro in Uganda. East African Medical Journal 1995;72(6):349-54.
Uganda-Kampala 94-7 {published data only}
Zanzibar 1989 {unpublished data only}
  • Matteelli A, Haji H, Issa S, Mohamed K, Muchi J. In vivo sensitivity of Plasmodium falciparum to chloroquine, amodiaquine and sulfadoxine/pyrimethamine, Zanzibar, United Republic of Tanzania. WHO/MAL/90.1055. Geneva: World Health Organization, 1989.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Cameroon 1987-92
  • Louis FJ, Ringwald P, Rouet F, Bickii J, Obenson A, Migliani R, et al. Evolution of the susceptibility of Plasmodium falciparum to five antimalarial drugs in Cameroon from 1987 to 1992; Third Conference on International Travel Medicine; 1993 April 26-29; Paris.
CameroonCongo 91-2
  • Brasseur P, Agnamey P, Same Ekobo A, Samba G, Favennec L, Kouamouo J. [Interet de l'amodiaquine pour le traitement du Paludisme ...Plasmodium falciparum en Afrique de l'Ouest et du Centre].
Clarke 1990
Clarke 2003
  • Clarke M, Oxman AD, editors. Optimal search strategy. Cochrane Reviewers' Handbook 4.1.6 [updated January 2003]; Appendix 5c. The Cochrane Library, Issue 1, 2003. Oxford: Update Software. Updated quarterly.
Coopman 1993
Hatton 1986
IASG 2002
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Kenya 1990-1
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Kenya 1994
  • Nevill C. Unpublished.
MacIntosh 2002
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Maggs 1988
  • Maggs JL, Tingle MD, Kitteringham NR, Park BK. Drug-protein conjugates--XIV. Mechanisms of formation of protein-arylating intermediates from amodiaquine, a myelotoxin and hepatotoxin in man. Biochemical Pharmacology 1988;37(2):303-11.
Maputo 1987
  • Vaz Dinis D, Schapira A. [Etude comparative de la sulfadoxine-pyrimethamine et de l'amodiaquine + sulfadoxine-pyrimethamine dans le traitement du paludisme a Plasmodium falciparum chloroquino-resistant a Maputo, Mozambique]. Bulletin de la Societe de Pathologie Exotique 1990;83:521-8.
Neftel 1986
Review Manager 5
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WHO 1990
  • World Health Organization. Practical chemotherapy of malaria. WHO Technical Report Series 1990;805.
WHO 1993
  • World Health Organization. WHO expert committee on malaria. Nineteenth report.. Geneva: World Health Organization, 1993.
WHO 1997
  • World Health Organization. Division of Control of Tropical Diseases. Management of uncomplicated malaria and the use of antimalarial drugs for the protection of travellers: report of an informal consultation, Geneva, 18-21 September 1995 [WHO/MAL/96.1075]. Geneva: World Health Organization, 1997.
WHO 2002
  • World Health Organization. The selection and use of essential medicines: Report of the WHO Expert Committee (including the 12th Model List of Essential Medicines). http://www.who.int/medicines/organization/par/edl/Report2002version14.doc (accessed June 2002). Geneva: World Health Organization, 2002.
Winstanley 1990
  • Winstanley PA, Simooya O, Kofi-Ekue JM, Walker O, Salako LA, Edwards G, Orme ML, Breckenridge AM. The disposition of amodiaquine in Zambians and Nigerians with malaria. British Journal of Clinical Pharmacology 1990;29(6):695-701.
Yaoundé 1990

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Olliaro 1996
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