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Intervention Review

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Anti-D administration in pregnancy for preventing Rhesus alloimmunisation

  1. Caroline A Crowther*,
  2. Philippa Middleton,
  3. Rosemary D McBain

Editorial Group: Cochrane Pregnancy and Childbirth Group

Published Online: 28 FEB 2013

Assessed as up-to-date: 14 NOV 2012

DOI: 10.1002/14651858.CD000020.pub2


How to Cite

Crowther CA, Middleton P, McBain RD. Anti-D administration in pregnancy for preventing Rhesus alloimmunisation. Cochrane Database of Systematic Reviews 2013, Issue 2. Art. No.: CD000020. DOI: 10.1002/14651858.CD000020.pub2.

Author Information

  1. The University of Adelaide, ARCH: Australian Research Centre for Health of Women and Babies, Discipline of Obstetrics and Gynaecology, Adelaide, South Australia, Australia

*Caroline A Crowther, ARCH: Australian Research Centre for Health of Women and Babies, Discipline of Obstetrics and Gynaecology, The University of Adelaide, Women's and Children's Hospital, 72 King William Road, Adelaide, South Australia, 5006, Australia. caroline.crowther@adelaide.edu.au.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 28 FEB 2013

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This is not the most recent version of the article. View current version (03 SEP 2015)

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Huchet 1987 {published data only}
  • Huchet J, Dallemagne S, Huchet C, Brossard Y, Larsen M, Parnet-Mathieu F. The antepartum use of anti-D immunoglobulin in rhesus negative women. Parallel evaluation of fetal blood cells passing through the placenta. The results of a multi-centre study carried out in the region of Paris. European Journal of Obstetrics, Gynecology, and Reproductive Biology 1987;16:101-11.
Lee 1995 {published data only}

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Ismail 2002 {published and unpublished data}
  • Ismail K, Kilby M, Alfirevic Z, Khan K, Whittle M. Prospective randomised trial of alloimmunisation management (PRAM). Journal of Obstetrics and Gynaecology 2002;22(2 Suppl):S33.

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Manjunath 2008 {published data only}
  • Manjunath AP. A clinical trial to study the effect of injection anti D administered during pregnancy for Rh negative mothers. Clinical Trials Registry - India (CTRI) (http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=172) 2008 (accessed 14 March 2012).

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Bishler 2003
Boruchov 2005
  • Boruchov AM, Heller G, Veri MC, Bonvini E, Ravetch JV, Young JW. Activating and inhibitory IgG Fc receptors on human DCs mediate opposing functions. Journal of Clinical Investigation 2005;115:2914-23.
Bowman 1965
Bowman 1996
Chilcott 2002
  • Chilcott J, Lloyd Jones M, Wight J, Forman K, Wray J, Beverley C. A review of the clinical effectiveness and cost effectiveness of routine anti-D prophylaxis for pregnant women who are Rhesus (RhD) negative. London: National Institute of Clinical Excellence, 2002.
Chown 1954
  • Chown B. Anaemia from bleeding of the fetus into the mother’s circulation. Lancet 1954;263(6824):1213.
Contreras 1998
Coopamah 2003
  • Coopamah MD, Freeman J, Semple JW. Anti-D initially stimulates an Fc-dependant leukocyte oxidative burst and subsequently suppresses erythrophagocytosis via interleukin-1 receptor antagonist. Blood 2003;102:2862-7.
Craig 1998
Crowther 1997
  • Crowther C, Middleton P. Anti-D administration after childbirth for preventing Rhesus alloimmunisation. Cochrane Database of Systematic Reviews 1997, Issue 2. [DOI: 10.1002/14651858.CD000021]
Davey 1979
Engelfriet 2003
  • Engelfriet CP, Reesink HW, Judd WJ, Ulander VM, Kuosmanen M, Koskinen S, et al. Current status of immunoprophylaxis with anti-D immunoglobin. Vox Sanguinis 2003;85(4):328-37.
Gravenhorst 1989
  • Gravenhorst JB. Rhesus isoimmunisation. In: Chalmers I, Enkin MW, Keirse MJNC editor(s). Effective Care in Pregnancy and Childbirth. Oxford: Oxford University Press, 1989:565-77.
Gunson 1976
Higgins 2011
  • Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Jones 2004
Kumpel 2001
Kumpel 2002
Liumbruno 2010
  • Liumbruno GM, D’Alessandro A, Rea F, Piccinini V, Catalano L, Calizzani G, et al. The role of antenatal immunoprophylaxis in the prevention of maternal-foetal anti-Rh(D) alloimmunisation. Blood Transfusion 2010;8(1):8-16.
Mackenzie 2006
National Blood 2003
  • National Blood Authority. Guidelines on the prophylactic use of Rh D immunoglobulin (anti-D) in obstetrics. Canberra, ACT: NHMRC, 2003.
NHS 2011
  • NHS National Institute for Health and Clinical Excellece. Routine antenatal anti-D prophylaxis for women who are rhesus D negative: Review of NICE technology appraisal guidance 41. http://www.nice.org.uk/ (accessed 14 November 2012).
RANZCOG 2004
  • Royal Australian and New Zealand College of Obstetricians and Gynaecologists. Guidelines for the use of RhD immunoglobulin (Anti-D) in obstetrics in Australia. www.ranzcog.edu.au/ (accessed 2 November 2012).
RCOG 2011
  • Royal College of Obstetricians and Gynaecologists. The use of anti-D immunoglobulin for rhesus D prophylaxis. Green-top guideline. http://www.rcog.org.uk/ (accessed 14 November 2012).
RevMan 2011
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). 5.1. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2011.
Stern 1961
Turner 2012
  • Turner RM, Lloyd-Jones M, Anumba DO, Smith GC, Spiegelhalter DJ, Squires H, et al. Routine antenatal anti-d prophylaxis in women who are rh(d) negative: meta-analyses adjusted for differences in study design and quality. PLoS ONE 2012;7(2):e30711.
Zipursky 1967

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Crowther 1999
  • Crowther CA, Middleton P. Anti-D administration in pregnancy for preventing Rhesus alloimmunisation. Cochrane Database of Systematic Reviews 1999, Issue 2. [DOI: 10.1002/14651858.CD000020]