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Antibiotics for sore throat

  1. Anneliese Spinks1,*,
  2. Paul P Glasziou2,
  3. Chris B Del Mar2

Editorial Group: Cochrane Acute Respiratory Infections Group

Published Online: 5 NOV 2013

Assessed as up-to-date: 11 JUL 2013

DOI: 10.1002/14651858.CD000023.pub4


How to Cite

Spinks A, Glasziou PP, Del Mar CB. Antibiotics for sore throat. Cochrane Database of Systematic Reviews 2013, Issue 11. Art. No.: CD000023. DOI: 10.1002/14651858.CD000023.pub4.

Author Information

  1. 1

    Griffith University, School of Medicine, Meadowbrook, Queensland, Australia

  2. 2

    Bond University, Centre for Research in Evidence-Based Practice (CREBP), Gold Coast, Queensland, Australia

*Anneliese Spinks, School of Medicine, Griffith University, University Drive, Meadowbrook, Queensland, 4031, Australia. anneliese.spinks@csiro.au. a.spinks@griffith.edu.au.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 5 NOV 2013

SEARCH

[Figure 1]
Figure 1. 'Risk of bias' graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
[Figure 2]
Figure 2. 'Risk of bias' summary: review authors' judgements about each risk of bias item for each included study.
[Figure 3]
Figure 3. Summary of findings.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Antibiotics versus placebo for the treatment of sore throats: symptom of sore throat, Outcome 1 Symptom of sore throat on day 3.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Antibiotics versus placebo for the treatment of sore throats: symptom of sore throat, Outcome 2 Symptom of sore throat on day 3: blind versus unblinded studies.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Antibiotics versus placebo for the treatment of sore throats: symptom of sore throat, Outcome 3 Symptom of sore throat on day 3: antipyretics versus no antipyretics.
[Analysis 1.4]
Analysis 1.4. Comparison 1 Antibiotics versus placebo for the treatment of sore throats: symptom of sore throat, Outcome 4 Symptom of sore throat on day 3: GABHS-positive throat swab, negative swab, untested/inseparable.
[Analysis 1.5]
Analysis 1.5. Comparison 1 Antibiotics versus placebo for the treatment of sore throats: symptom of sore throat, Outcome 5 Symptom of sore throat at one week (6 to 8 days).
[Analysis 1.6]
Analysis 1.6. Comparison 1 Antibiotics versus placebo for the treatment of sore throats: symptom of sore throat, Outcome 6 Symptom of sore throat at one week (6 to 8 days): blind versus unblinded studies.
[Analysis 1.7]
Analysis 1.7. Comparison 1 Antibiotics versus placebo for the treatment of sore throats: symptom of sore throat, Outcome 7 Symptom of sore throat at one week (6 to 8 days): GABHS-positive throat swab, GABHS-negative swab.
[Analysis 2.1]
Analysis 2.1. Comparison 2 Antibiotics versus control for the treatment of sore throat: symptom of fever, Outcome 1 Symptom of fever on day 3.
[Analysis 2.2]
Analysis 2.2. Comparison 2 Antibiotics versus control for the treatment of sore throat: symptom of fever, Outcome 2 Symptom of fever on day 3: blinded versus unblinded studies.
[Analysis 2.3]
Analysis 2.3. Comparison 2 Antibiotics versus control for the treatment of sore throat: symptom of fever, Outcome 3 Symptom of fever on day 3: children compared with adults.
[Analysis 2.4]
Analysis 2.4. Comparison 2 Antibiotics versus control for the treatment of sore throat: symptom of fever, Outcome 4 Symptom of fever at 1 week (6 to 8 days).
[Analysis 3.1]
Analysis 3.1. Comparison 3 Antibiotics versus control for the treatment of sore throat: symptom of headache, Outcome 1 Symptom of headache on day 3.
[Analysis 3.2]
Analysis 3.2. Comparison 3 Antibiotics versus control for the treatment of sore throat: symptom of headache, Outcome 2 Symptom of headache on day 3: blinded versus unblinded studies.
[Analysis 4.1]
Analysis 4.1. Comparison 4 Antibiotics versus placebo for the treatment of sore throat: incidence of complications, Outcome 1 Incidence of acute rheumatic fever within 2 months. Rheumatic fever defined by clinical diagnosis.
[Analysis 4.2]
Analysis 4.2. Comparison 4 Antibiotics versus placebo for the treatment of sore throat: incidence of complications, Outcome 2 Incidence of acute rheumatic fever within 2 months. Penicillin versus placebo.
[Analysis 4.3]
Analysis 4.3. Comparison 4 Antibiotics versus placebo for the treatment of sore throat: incidence of complications, Outcome 3 Incidence of acute rheumatic fever within 2 months: early (pre-1975) versus late studies (post-1975).
[Analysis 4.4]
Analysis 4.4. Comparison 4 Antibiotics versus placebo for the treatment of sore throat: incidence of complications, Outcome 4 Incidence of otitis media within 14 days. Otitis media defined by clinical diagnosis.
[Analysis 4.5]
Analysis 4.5. Comparison 4 Antibiotics versus placebo for the treatment of sore throat: incidence of complications, Outcome 5 Incidence of otitis media within 14 days: early (pre-1975) versus late studies (post-1975).
[Analysis 4.6]
Analysis 4.6. Comparison 4 Antibiotics versus placebo for the treatment of sore throat: incidence of complications, Outcome 6 Incidence of sinusitis within 14 days. Sinusitis defined by clinical diagnosis.
[Analysis 4.7]
Analysis 4.7. Comparison 4 Antibiotics versus placebo for the treatment of sore throat: incidence of complications, Outcome 7 Incidence of quinsy within 2 months. Quinsy defined by clinical diagnosis.
[Analysis 4.8]
Analysis 4.8. Comparison 4 Antibiotics versus placebo for the treatment of sore throat: incidence of complications, Outcome 8 Incidence of acute glomerulonephritis within 1 month. Acute glomerulonephritis defined by clinical diagnosis.