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Antibiotics for sore throat

  1. Anneliese Spinks1,*,
  2. Paul P Glasziou2,
  3. Chris B Del Mar2

Editorial Group: Cochrane Acute Respiratory Infections Group

Published Online: 5 NOV 2013

Assessed as up-to-date: 11 JUL 2013

DOI: 10.1002/14651858.CD000023.pub4


How to Cite

Spinks A, Glasziou PP, Del Mar CB. Antibiotics for sore throat. Cochrane Database of Systematic Reviews 2013, Issue 11. Art. No.: CD000023. DOI: 10.1002/14651858.CD000023.pub4.

Author Information

  1. 1

    Griffith University, School of Medicine, Meadowbrook, Queensland, Australia

  2. 2

    Bond University, Centre for Research in Evidence-Based Practice (CREBP), Gold Coast, Queensland, Australia

*Anneliese Spinks, School of Medicine, Griffith University, University Drive, Meadowbrook, Queensland, 4031, Australia. anneliese.spinks@csiro.au. a.spinks@griffith.edu.au.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 5 NOV 2013

SEARCH

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Bennike 1951 {published data only}
Brink 1951 {published data only}
Brumfitt 1957 {published data only}
  • Brumfitt WS, Slater DH. Treatment of acute sore throat with penicillin: a controlled trial among young soldiers. Lancet 1957;272(6958):8-11.
Catanzaro 1954 {published data only}
Chamovitz 1954 {published data only}
Chapple 1956 {published data only}
  • Chapple LM, Paulett JD, Tuckman E, Woodall JT, Tomlinson AJH, McDonald JC. Treatment of acute sore throat in general practice. British Medical Journal 1956;March(4969):705-8.
Dagnelie 1996 {published and unpublished data}
  • Dagnelie CF, van-der-Graaf Y, De Melker RA. Do patients with sore throat benefit from penicillin? A randomised double-blind placebo-controlled clinical trial with penicillin V in general practice. British Journal of General Practice 1996;46(411):589-93.
De Meyere 1992 {published data only}
  • De Meyere M, Mervielde Y, Verschraegen G, Bogaert M. Effect of penicillin on the clinical course of streptococcal pharyngitis in general practice. European Journal of Clinical Pharmacology 1992;43(6):581-5.
Denny 1950 {published data only}
Denny 1953 {published data only}
El-Daher 1991 {published data only}
  • El-Daher NT, Hijazi SS, Rawashdeh NM, Al-Khalil IA, Abu-Ektaish FM, Abdel-Latif DI. Immediate vs. delayed treatment of Group A beta-hemolytic streptococcal pharyngitis with penicillin V. Pediatric Infectious Diseases Journal 1991;10(2):126-30.
Howe 1997 {published and unpublished data}
  • Howe RW, Millar MR, Coast J, Whitfield M, Peters TJ, Brookes S. A randomized controlled trial of antibiotics on symptom resolution in patients presenting to their general practitioner with a sore throat. British Journal of General Practice 1997;47(418):280-4.
Krober 1985 {published data only}
Landsman 1951 {published data only}
Leelarasamee 2000 {published data only}
  • Leelarasamee A, Leowattana W, Tobunluepop P, Chub-upakarn S, Artavetakan W, Jarupoonphol V, et al. Amoxycillin for fever and sore throat due to non-exudative pharyngotonsillitis: beneficial or harmful?. International Journal of Infectious Diseases 2000;4(2):70-4.
Little 1997 {published and unpublished data}
  • Little P, Gould C, Williamson I, Warner G, Gantley M, Kinmonth AL. Reattendance and complications in a randomised trial of prescribing strategies for sore throat: the medicalising effect of prescribing antibiotics. BMJ 1997;315(7104):350-2.
  • Little P, Williamson I, Warner G, Gould C, Gantley M, Kinmonth AL. Open randomised trial of prescribing strategies in managing sore throat. BMJ 1997;314:722-7.
MacDonald 1951 {published data only}
Middleton 1988 {published data only}
Nelson 1984 {published data only}
Petersen 1997 {published data only}
  • Peterson K, Phillips RS, Soukup J, Komaroff AL, Aronson M. The effect of erythromycin on resolution of symptoms among adults with pharyngitis not caused by Group A Streptococcus. Journal of General Internal Medicine 1997;12(2):95-101.
Pichichero 1987 {published data only}
  • Pichichero FA, Talpey WB, Green JL, Francis AB, Roghmann KJ, Hoekelman RA. Adverse and beneficial effects of immediate treatment of group A beta haemolytic streptococcal pharyngitis with penicillin. Pediatric Infectious Disease 1987;6(7):635-43.
Siegel 1961 {published data only}
Taylor 1977 {published data only}
  • Taylor B, Abbott GD, McKerr M, Fergusson DM. Amoxycillin and co-trimoxazole in presumed viral respiratory infections of childhood: placebo controlled trial. British Medical Journal 1977;2(6086):552-4.
Wannamaker 1951 {published data only}
  • Wannamaker LW, Rammelkamp CH, Denny FW, Brink WR, Houser HB, Hahn EO. Prophylaxis of acute rheumatic fever by treatment of the preceding streptococcal infection with various amounts of depot penicillin. American Journal of Medicine 1951;10:673-94.
Whitfield 1981 {published data only}
Zwart 2000 {published and unpublished data}
  • Zwart S, Sachs AP, Rujis GJ, Gubbels JW, Hoes AW, de Melker RA. Penicillin for acute sore throat: randomised double blind trial seven days versus three days treatment or placebo in adults. BMJ 2000;320(7228):150-4.
Zwart 2003 {published data only}

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Barwitz 1999 {published data only}
  • Barwitz HJK. Common cold - trial to rationalize management in general practice by recommendation [Erkaltung: eine Handlungsempfehlung]. Zeitschrift fur Allgemeinmedizin 1999;75:932-8.
Bass 1986 {published data only}
Bishop 1952 {published data only}
  • Bishop JM, Peden AS, Prankerd TAJ, Cawley RH. Acute sore throat. Clinical features, aetiology and treatment. Lancet 1952;1:1183-7.
Catanzaro 1958 {published data only}
  • Catanzaro FJ, Chamovitz R. Prevention of rheumatic fever by treatment of streptococcal infections: factors responsible for failures. New England Journal of Medicine 1958;259:51-7.
Cruickshank 1960 {published data only}
  • Cruickshank R. Sore throat: a controlled therapeutic trial in young adults. Controlled Clinical Trials: paper delivered at the conference convened by the Council for International Organisation of Medical Sciences. Oxford: Blackwell, 1960:38-44.
Dowell 2001 {published data only}
  • Dowell J, Pitkethly M, Bain J, Martin S. A randomised controlled trial of delayed antibiotic prescribing as a strategy for managing uncomplicated respiratory tract infection in primary care. British Journal of General Practice 2001;51:200-5.
Gerber 1985 {published data only}
  • Gerber MA, Spadaccini LJ, Wright LL, Deutsch L, Kaplan EL. Twice-daily penicillin in the treatment of streptococcal pharyngitis. American Journal of Diseases of Children 1985;139:1145-8.
Gerber 1989 {published data only}
Ginsburg 1980 {published data only}
  • Ginsburg CM, McCracken GH, Crow SD, Steinberg JB, Cope F. A controlled comparative study of penicillin V and cefadroxil therapy on Group A streptococcal tonsillopharyngitis. Journal of International Medical Research 1980;8(Suppl 1):82-6.
Guthrie 1988 {published data only}
  • Guthrie RM, Ruoff GE, Rofman BA, Ginsberg D, Karp RR, Brown SM, et al. Aetiology of acute pharyngitis and clinical response to empirical therapy with erythromycin versus amoxicillin. Family Practice 1988;5:29-35.
Haverkorn 1971 {published data only}
  • Haverkorn MV, Goslings WRO. Streptococcal pharyngitis in the general population. A controlled study of streptococcal pharyngitis and its complications in the Netherlands. Journal of Infectious Diseases 1971;124:339-47.
Herz 1988 {published data only}
Howie 1970 {published data only}
  • Howie JGR, Clark GA. Double-blind trial of early demethylchlortetracycline in minor respiratory illness in general practice. Lancet 1970;Nov 28:1099-102.
Jensen 1991 {published data only}
Kapur 2011 {published data only}
  • Kapur A, Hannay D, Baxter G, Mitra A. A randomized prospective study to evaluate the natural history of acute upper respiratory infections in children and provide guidance for health professionals. American Journal of Respiratory and Clinical Care Medicine 2011;183:A4934.
Kolobukhina 2011 {published data only}
  • Kolobukhina LV, Merkulova LN, Schelkanov MY, Isaeva EI, Kruzhkova IS, Malikov VE, et al. The efficacy of Ingavirin in the combined treatment of ARVI complicated by tonsillitis. Vestnik Otorinolaringologii 2011;6:91-5.
Marlow 1989 {published data only}
  • Marlow RA, Torrez AJ, Haxby D. The treatment of non streptococcal pharyngitis with erythromycin: a preliminary study. Family Medicine 1989;21:425-7.
Massell 1951 {published data only}
  • Massell BF, Sturgis GP, Knobloch JD, Streeper RB, Hall TN, Norcross P. Prevention of rheumatic fever by prompt penicillin therapy of hemolytic streptococcic respiratory infections. Journal of the American Medical Association 1951;146(16):1469-74.
McDonald 1985 {published data only}
  • McDonald CJ, Tierny WM, Hui SL, French MLV, Leland DS, Jones RB. A controlled trial of erythromycin in adults with nonstreptococcal pharyngitis. Journal of Infectious Diseases 1985;152:1093-4.
Merenstein 1974 {published data only}
Morris 1956 {published data only}
  • Morris AJ, Chamovitz R, Catanzaro FJ, Rammelkamp CH. Prevention of rheumatic fever by treatment of previous streptococcic infections; effect of sulfadiazine. Journal of the American Medical Association 1956;160(2):114-6.
Nasonova 1999 {published data only}
  • Nasonova VA, Belov BS, Strachunsky LS, Sudilovskaya EI, Bogdanovich TM, Krechikova OI, et al. Antibacterial therapy of Streptococcus tonsillitis (quinsy and pharyngitis). Antibiotiki i Khimioterapiia 1999;44:19-23.
Pandraud 2002 {published data only}
Randolph 1985 {published data only}
Schalen 1985 {published data only}
  • Schalen L, Christenses P, Elisson I, Fex S, Kamme S, Schalen C. Inefficacy of penicillin V in acute laryngitis in adults. Evaluation from results of double-blind study. Annals of Otology Rhinology and Laryngology 1985;94:14-7.
Schalen 1993 {published data only}
Schwartz 1981 {published data only}
Shevrygin 2000 {published data only}
  • Shevrygin BV, Manuilov BM. Therapeutic efficacy of new drug Pharingal at acute inflammatory diseases of pharynx and tonsils in pediatrics [Terapevticheskaia effektivnost' novogo perparata Faringal pri ostrykh vospalitel'nykh zabolevaniiakh glotki i mindalin u detei]. Antibiotiki i Khimioterapiia 2000;45:34-6.
Shvartzman 1993 {published data only}
Stillerman 1986 {published data only}
Stromberg 1988 {published data only}
  • Stromberg A, Schwan A, Cars O. Five versus ten days treatment of group A streptococcal pharyngotonsillitis: a randomised controlled clinical trial with phenoxymethylpenicillin and cefadroxil. Scandinavian Journal of Infectious Disease 1988;20:36-46.
Supajatura 2012 {published data only}
  • Supajatura V, Pongbaibul Y, Tharavichitkul P. Mangosteen spray for efficacious treatment of streptococcal pharyngitis. International Journal of Infectious Diseases 2012;16S:e441.
Todd 1984 {published data only}
  • Todd JK, Todd N, Damato J, Todd WA. Bacteriology and treatment of purulent nasopharyngitis: a double blind, placebo-controlled evaluation. Pediatric Infectious Disease 1984;3:226-31.
Valkenburg 1971 {published data only}
  • Valkenburg HHMJ, Goslings WRO. Streptococcal pharyngitis in the general population. The attack rate if not treated with penicillin. Journal of Infectious Diseases 1971;124:783-6.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
ABS 1985
  • Australian Bureau of Statistics. Australian Health Survey. Canberra: AGPS: (Cat No 4311.0) 1985:11-52.
Del Mar 1992a
  • Del Mar C. Managing sore throat: a literature review. I. Making the diagnosis. Medical Journal of Australia 1992;156:572-5.
Del Mar 1992b
  • Del Mar C. Managing sore throats: a literature review. II. Do antibiotics confer benefit?. Medical Journal of Australia 1992;156:644-9.
Del Mar 1992c
  • Del Mar C. Spontaneously remitting disease, principles of management. Medical Journal of Australia 1992;157:101-7.
Froom 1990
  • Froom J, Culpepper L, Grob P, Bartelds A, Bowers P, Bridges-Webb C, et al. Diagnosis and antibiotic treatment of acute otitis media: report from International Primary Care Network. BMJ 1990;300:582-6.
Goslings 1963
  • Goslings WRO, Valkenberg HA, Bots AW, Lorrier JC. Attack rates of streptococcal pharyngitis, rheumatic fever and glomerulonephritis in the general population. A controlled pilot study of controlled streptococcal pharyngitis in one village. New England Journal of Medicine 1963;268:687-94.
Higgins 2011
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Horder 1954
  • Horder J, Horder E. Illness in general practice. Practitioner 1954;173:177-87.
Howie 1971
  • Howie JGR, Gill G, Durno D. Respiratory illness and antibiotic use in general practice. Journal of the Royal College of General Practitioners 1971;21:657-61.
Howie 1978
Howie 1985
Keith 2010
  • Keith T, Saxena S, Murray J, Sharland M. Risk-benefit analysis of restricting antimicrobial prescribing in children: what do we really know?. Current Opinion in Infectious Disease 2010;23:242-8.
Lefebvre 2011
  • Lefebvre C, Manheimer E, Glanville J. Chapter 6: Searching for studies. In: Higgins JPT, Green S editor(s). Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 [updated March 2011]. The Cochrane Collaboration. Available from www.cochrane-handbook.org. Chichester: Wiley-Blackwell, 2011.
Reveiz 2013
van Driel 2013
Venekamp 2013
  • Venekamp RP, Sanders S, Glasziou PP, Del Mar CB, Rovers MM. Antibiotics for acute otitis media in children. Cochrane Database of Systematic Reviews 2013, Issue 1. [DOI: 10.1002/14651858.CD000219.pub3]
Wessels 2011

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Del Mar 1997
  • Del Mar CB, Glasziou PP, Hayem M. Antibiotics for sore throat. Cochrane Database of Systematic Reviews 1997, Issue 2. [DOI: 10.1002/14651858.CD000023.pub3]
Del Mar 2000
  • Del Mar CB, Glasziou PP, Spinks AB. Antibiotics for sore throat. Cochrane Database of Systematic Reviews 2000, Issue 4. [DOI: 10.1002/14651858.CD000023.pub3]
Del Mar 2004
  • Del Mar CB, Glasziou PP, Spinks AB. Antibiotics for sore throat. Cochrane Database of Systematic Reviews 2004, Issue 2. [DOI: 10.1002/14651858.CD000023.pub3]
Del Mar 2006
  • Del Mar CB, Glasziou PP, Spinks AB. Antibiotics for sore throat. Cochrane Database of Systematic Reviews 2006, Issue 4. [DOI: 10.1002/14651858.CD000023.pub3]
Spinks 2009
  • Spinks AB, Glasziou PP, Del Mar CB. Antibiotics for sore throat. Cochrane Database of Systematic Reviews 2009, Issue 3. [DOI: 10.1002/14651858.CD000023.pub3]
Spinks 2011
  • Spinks AB, Glasziou PP, Del Mar CB. Antibiotics for sore throat. Cochrane Database of Systematic Reviews 2011, Issue 9. [DOI: 10.1002/14651858.CD000023.pub3]