Intervention Review

Calcium channel blockers for potential impaired fetal growth

  1. Lale Say1,*,
  2. A Metin Gülmezoglu2,
  3. G Justus Hofmeyr3

Editorial Group: Cochrane Pregnancy and Childbirth Group

Published Online: 7 OCT 2009

Assessed as up-to-date: 23 JUN 2009

DOI: 10.1002/14651858.CD000049

Database Title

Additional Information

How to Cite

Say L, Gülmezoglu AM, Hofmeyr GJ. Calcium channel blockers for potential impaired fetal growth. Cochrane Database of Systematic Reviews 1996, Issue 1. Art. No.: CD000049. DOI: 10.1002/14651858.CD000049.

Author Information

  1. 1

    World Health Organization, Department of Reproductive Health and Research, Geneva, Switzerland

  2. 2

    World Health Organization, UNDP/UNFPA/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction, Department of Reproductive Health and Research, Geneva, Switzerland

  3. 3

    University of the Witwatersrand, University of Fort Hare, Eastern Cape Department of Health, Department of Obstetrics and Gynaecology, East London Hospital Complex, East London, Eastern Cape, South Africa

*Lale Say, Department of Reproductive Health and Research, World Health Organization, 20 Avenue Appia, Geneva, 1211, Switzerland. sayl@who.int.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 7 OCT 2009

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Abstract

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  2. Abstract
  3. Plain language summary
  4. 摘要

Background

Calcium channel blockers may increase the blood flow to the fetus or may improve fetal-placental cellular energy generation. This could enhance fetal growth.

Objectives

The objectives of this review were to assess the effects of calcium channel blockers on fetal growth and neonatal morbidity and mortality in pregnancies where impaired fetal growth is suspected.

Search methods

We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (June 2009).

Selection criteria

Acceptably controlled trials of calcium channel blockers in women with potential impaired fetal growth.

Data collection and analysis

Eligibility and trial quality were assessed.

Main results

One study of 100 women (all smokers) was included. Mean birthweight was significantly higher in women receiving flunarizine compared to the control group. No other significant differences were found.

Authors' conclusions

There is not enough evidence to evaluate the use of calcium channel blockers for impaired fetal growth. The apparent beneficial effect of calcium channel blockers on birthweight warrants further investigation.

 

Plain language summary

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  2. Abstract
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  4. 摘要

Calcium channel blockers for potential impaired fetal growth

Too little evidence to show whether the unborn baby's growth improves when pregnant women take calcium channel blockers, and more research is needed.

Calcium channel blocker drugs relax muscles and lower blood pressure by reducing the intake of calcium into some cells. It has been thought that these drugs may improve the growth of an unborn baby who is growing more slowly than expected in the womb (impaired fetal growth). The review of trials has found too little evidence from trials on the effects of pregnant women taking calcium channel blockers. Only one trial, involving 100 women, has been included. However, there is some evidence of improved growth in some babies, and more research is needed into the effects of these drugs on both smoking and non-smoking women and their babies.

 

摘要

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  2. Abstract
  3. Plain language summary
  4. 摘要

背景

鈣離子阻斷劑用於疑似生長不佳之胎兒

鈣離子阻斷劑可增加通往胎兒的血流或促進胎兒胎盤細胞能量生成，因而促進胎兒生長。

目標

回顧目標是評估鈣離子阻斷劑用於疑似胎兒發育不佳時，對於胎兒生長和新生兒罹病率與死亡率的效果。

搜尋策略

我們搜尋Cochrane Pregnancy and Childbirth Group's Trials Register (2006年11月)。

選擇標準

接受的是鈣離子阻斷劑用於胎兒可能發育不佳的孕婦之對照試驗。

資料收集與分析

評估適用性與試驗品質。

主要結論

納入1篇研究、100名婦女(都是吸煙者)。接受flunarizine組的平均出生體重顯著高於控制組，沒有發現其他顯著差異。

作者結論

沒有足夠證據評估鈣離子阻斷劑用於胎兒發育不佳的效果，鈣離子阻斷劑對於出生體重的助益還需要後續研究。

翻譯人

此翻譯計畫由臺灣國家衛生研究院(National Health Research Institutes, Taiwan)統籌。

總結

證據太少而無法顯示孕婦服用鈣離子阻斷劑是否改善胎兒的生長，需要更多研究。藉由減少鈣離子進入細胞，鈣離子阻斷劑可鬆弛肌肉且降低血壓。一般認為這類藥物可以改善子宮內生長比預期緩慢(胎兒發育不佳)之胎兒的生長狀況。試驗回顧發現，孕婦使用鈣離子阻斷劑的證據太少，不過，有些證據顯示某些嬰兒成長有改善，需要更多研究探討這些藥物對於抽煙和未抽煙的孕婦與其胎兒的影響。

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