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Intervention Review

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Drugs for treating urinary schistosomiasis

  1. Anthony Danso-Appiah1,*,
  2. Jürg Utzinger2,
  3. Jianping Liu3,
  4. Piero Olliaro4

Editorial Group: Cochrane Infectious Diseases Group

Published Online: 16 JUL 2008

Assessed as up-to-date: 15 OCT 2007

DOI: 10.1002/14651858.CD000053.pub2


How to Cite

Danso-Appiah A, Utzinger J, Liu J, Olliaro P. Drugs for treating urinary schistosomiasis. Cochrane Database of Systematic Reviews 2008, Issue 3. Art. No.: CD000053. DOI: 10.1002/14651858.CD000053.pub2.

Author Information

  1. 1

    Liverpool School of Tropical Medicine, International Health Group, Liverpool, UK

  2. 2

    Swiss Tropical Institute, Department of Public Health and Epidemiology, Basel, Switzerland

  3. 3

    Beijing University of Chinese Medicine, Centre for Evidence-Based Chinese Medicine , Beijing, China

  4. 4

    World Health Organization, Special Programme for Research and Training in Tropical Diseases (TDR), Geneva, Switzerland

*Anthony Danso-Appiah, International Health Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK. tdappiah@yahoo.co.uk.

Publication History

  1. Publication Status: New search for studies and content updated (conclusions changed)
  2. Published Online: 16 JUL 2008

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This is not the most recent version of the article. View current version (06 AUG 2014)

[Figure 1]
Figure 1. Metrifonate (different regimens) vs praziquantel (30 mg/kg or 40 mg/kg, single dose): Parasitological failure.
[Figure 2]
Figure 2. Metrifonate (10 mg/kg x 1) vs metrifonate (10 mg/kg x 3): Parasitological failure.
[Figure 3]
Figure 3. Praziquantel (2 x 20 mg/kg) vs praziquantel (standard 40 mg/kg): Parasitological failure.
[Figure 4]
Figure 4. Praziquantel (30 mg/kg) vs praziquantel (standard 40 mg/kg): Parasitological failure.
[Figure 5]
Figure 5. Praziquantel (20 mg/kg) vs praziquantel (standard 40 mg/kg): Parasitological failure.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Metrifonate vs placebo, Outcome 1 Parasitological failure.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Metrifonate vs placebo, Outcome 2 Change in mean haemoglobin (g/dL).
[Analysis 2.1]
Analysis 2.1. Comparison 2 Praziquantel vs placebo, Outcome 1 Parasitological failure.
[Analysis 2.2]
Analysis 2.2. Comparison 2 Praziquantel vs placebo, Outcome 2 Change in mean haemoglobin (g/dL).
[Analysis 3.1]
Analysis 3.1. Comparison 3 Artesunate vs placebo, Outcome 1 Parasitological failure at 2 months.
[Analysis 4.1]
Analysis 4.1. Comparison 4 Praziquantel plus artesunate vs placebo, Outcome 1 Parasitological failure at 2 months.
[Analysis 5.1]
Analysis 5.1. Comparison 5 Praziquantel plus albendazole vs placebo, Outcome 1 Parasitological failure at 1 to 4 months.
[Analysis 5.2]
Analysis 5.2. Comparison 5 Praziquantel plus albendazole vs placebo, Outcome 2 Change in mean haemoglobin (g/dL).
[Analysis 6.1]
Analysis 6.1. Comparison 6 Metrifonate (different regimens) vs praziquantel (30 mg/kg or 40 mg/kg, single dose), Outcome 1 Parasitological failure.
[Analysis 6.2]
Analysis 6.2. Comparison 6 Metrifonate (different regimens) vs praziquantel (30 mg/kg or 40 mg/kg, single dose), Outcome 2 Mean haemoglobin (g/dL).
[Analysis 7.1]
Analysis 7.1. Comparison 7 Metrifonate (10 mg/kg every 4 months for 1 year) vs standard praziquantel dose: effect on infection level, Outcome 1 Parasitological failure at 12 months: light infection.
[Analysis 7.2]
Analysis 7.2. Comparison 7 Metrifonate (10 mg/kg every 4 months for 1 year) vs standard praziquantel dose: effect on infection level, Outcome 2 Parasitological failure at 12 months: heavy infection.
[Analysis 8.1]
Analysis 8.1. Comparison 8 Metrifonate (5 mg/kg x 3, given 1 day) vs metrifonate (7.5 mg/kg x 3, fortnightly), Outcome 1 Parasitological failure at 1 month.
[Analysis 9.1]
Analysis 9.1. Comparison 9 Metrifonate (10 mg/kg x 1) plus praziquantel (10 mg/kg) vs praziquantel (40 mg/kg), Outcome 1 Parasitological failure at 3 months.
[Analysis 10.1]
Analysis 10.1. Comparison 10 Metrifonate (10 mg/kg x 1) vs metrifonate (10 mg/kg x 1) plus praziquantel (10 mg/kg x 1), Outcome 1 Parasitological failure at 3 months.
[Analysis 11.1]
Analysis 11.1. Comparison 11 Artesunate plus praziquantel vs praziqunatel alone, Outcome 1 Parasitological failure at 2 months.
[Analysis 12.1]
Analysis 12.1. Comparison 12 Metrifonate: different doses, Outcome 1 10 mg/kg x 2 vs 10 mg/kg x 3.
[Analysis 12.2]
Analysis 12.2. Comparison 12 Metrifonate: different doses, Outcome 2 10 mg/kg x 1 vs 10 mg/kg x 3.
[Analysis 13.1]
Analysis 13.1. Comparison 13 Praziquantel: different doses vs standard 40 mg/kg, Outcome 1 Parasitological failure: 2 x 20 mg/kg.
[Analysis 13.2]
Analysis 13.2. Comparison 13 Praziquantel: different doses vs standard 40 mg/kg, Outcome 2 Parasitological failure: 30 mg/kg.
[Analysis 13.3]
Analysis 13.3. Comparison 13 Praziquantel: different doses vs standard 40 mg/kg, Outcome 3 Parasitolotical failure: 20 mg/kg.
[Analysis 13.4]
Analysis 13.4. Comparison 13 Praziquantel: different doses vs standard 40 mg/kg, Outcome 4 Proportion cleared of haematuria.
[Analysis 13.5]
Analysis 13.5. Comparison 13 Praziquantel: different doses vs standard 40 mg/kg, Outcome 5 Parasitiological failure: 30 mg/kg vs 40 mg/kg at 3 months' follow up.
[Analysis 14.1]
Analysis 14.1. Comparison 14 Praziquantel: different doses vs standard 40 mg/kg, Outcome 1 Parasitological failure rate at 1 to 12 months.