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Intervention Review

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Drugs for treating urinary schistosomiasis

  1. Anthony Danso-Appiah1,*,
  2. Jürg Utzinger2,
  3. Jianping Liu3,
  4. Piero Olliaro4

Editorial Group: Cochrane Infectious Diseases Group

Published Online: 16 JUL 2008

Assessed as up-to-date: 15 OCT 2007

DOI: 10.1002/14651858.CD000053.pub2


How to Cite

Danso-Appiah A, Utzinger J, Liu J, Olliaro P. Drugs for treating urinary schistosomiasis. Cochrane Database of Systematic Reviews 2008, Issue 3. Art. No.: CD000053. DOI: 10.1002/14651858.CD000053.pub2.

Author Information

  1. 1

    Liverpool School of Tropical Medicine, International Health Group, Liverpool, UK

  2. 2

    Swiss Tropical Institute, Department of Public Health and Epidemiology, Basel, Switzerland

  3. 3

    Beijing University of Chinese Medicine, Centre for Evidence-Based Chinese Medicine , Beijing, China

  4. 4

    World Health Organization, Special Programme for Research and Training in Tropical Diseases (TDR), Geneva, Switzerland

*Anthony Danso-Appiah, International Health Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK. tdappiah@yahoo.co.uk.

Publication History

  1. Publication Status: New search for studies and content updated (conclusions changed)
  2. Published Online: 16 JUL 2008

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This is not the most recent version of the article. View current version (06 AUG 2014)

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Aden Abdi 1989 {published data only}
  • Aden Abdi Y, Gustafsson LL. Field trial of the efficacy of a simplified and standard metrifonate treatments of Schistosoma haematobium. European Journal of Clinical Pharmacology 1989;37(4):371-4.
Beasley 1999 {published data only}
Befidi-Mengue 1992 {published data only}
  • Befidi-Mengue RN, Ratard RC, D'Alessandro A, Rice J, Befidi-Mengue R, Kouemeni LE, et al. The impact of Schistosoma haematobium infection and of praziquantel treatment on the growth of primary school children in Bertoua, Cameroon. Journal of Tropical Medicine and Hygiene 1992;95(6):404-9.
Borrmann 2001 {published data only}
  • Borrmann S, Szlezák N, Faucher JF, Matsiegui PB, Neubauer R, Binder RK, et al. Artesunate and praziquantel for the treatment of Schistosoma haematobium infections: a double-blind, randomized, placebo-controlled study. Journal of Infectious Diseases 2001;184(10):1363-6.
Davis 1981 {published data only}
  • Davis A, Biles JE, Ulrich AM. Initial experiences with praziquantel in the treatment of human infections due to Schistosoma haematobium. Bulletin of the World Health Organization 1979;57(5):773-9.
  • Davis A, Biles JE, Ulrich AM, Dixon H. Tolerance and efficacy of praziquantel in phase II A and II B therapeutic trials in Zambian patients. Arzneimittel-Forschung 1981;31(3a):568-74.
Doehring 1985 {published data only}
  • De Jonge N, Schommer G, Feldmeier H, Krijger GW, Dafalla AA, Bienzle U, et al. Mixed Schistosoma haematobium and S. mansoni infection: effect of different treatments on the serum level of circulating anodic antigen (CAA). Acta Tropica 1991;48(1):25-35.
  • Doehring E, Ehrich JH, Vester U, Feldmeier H, Poggensee U, Brodehl J. Proteinuria, hematuria, and leukocyturia in children with mixed urinary and intestinal schistosomiasis. Kidney International 1985;28(3):520-5.
  • Doehring E, Poggensee U, Feldmeier H. The effect of metrifonate in mixed Schistosoma haematobium and Schistosoma mansoni infections in humans. American Journal of Tropical Medicine and Hygiene 1986;35(2):323-39.
Jewsbury 1977 {published data only}
  • Jewsbury JM, Cooke MJ. Prophylaxis of schistosomiasis - field trial of metrifonate for the prevention of human infection. Annals of Tropical Medicine and Parasitology 1976;70(3):361-3.
  • Jewsbury JM, Cooke MJ, Weber MC. Field trial of metrifonate in the treatment and prevention of schistosomiasis infection in man. Annals of Tropical Medicine and Parasitology 1977;71(1):67-83.
Jinabhai 2001 {published data only}
  • Jinabhai CC, Taylor M, Coutsoudis A, Coovadia HM, Tomkins AM, Sullivan KR. Epidemiology of helminth infections: implications for parasite control programmes, a South African perspective. Public Health Nutrition 2001;4(6):1211-9.
Kardaman 1985 {published data only}
  • Kardaman MW, Fenwick A, el Igail AB, el Tayeb M, Daffalla AA, Dixon HG. Treatment with praziquantel of schoolchildren with concurrent Schistosoma mansoni and S. haematobium infections in Gezira, Sudan. Journal of Tropical Medicine and Hygiene 1985;88(2):105-9.
King 1988 {published data only}
  • King CH, Lombardi G, Lombardi C, Greenblatt R, Hodder S, Kinyanjui H, et al. Chemotherapy based control of schistosomiasis haematobia. I. Metrifonate versus praziquantel in control of intensity and prevalence of infection. American Journal of Tropical Medicine and Hygiene 1988;39(3):295-05.
  • King CH, Lombardi G, Lombardi C, Greenblatt R, Hodder S, Kinyanjui H, et al. Chemotherapy-based control of schistosomiasis haematobia. II. Metrifonate vs. praxiquantel in control of infection-associated morbidity. American Journal of Tropical Medicine and Hygiene 1990;42(6):587-95.
  • King CH, Muchiri E, Ouma JH, Koech D. Chemotherapy-based control of schistosomiasis haematobia. IV. Impact of repeated annual chemotherapy on prevalence and intensity of Schistosoma haematobium infection in an endemic area of Kenya. American Journal of Tropical Medicine and Hygiene 1991;45(4):498-508.
  • King CH, Muchiri EM, Ouma JH. Age-targeted chemotherapy for control of urinary schistosomiasis in endemic populations. Memórias do Instituto Oswaldo Cruz 1992;87 Suppl 4:203-10.
King 1989 {published data only}
  • King CH, Wiper DW 3rd, De Stigter KV, Peters PA, Koech D, Ouma JH, et al. Dose-finding study for praziquantel therapy of Schistosoma haematobium in Coast Province, Kenya. American Journal of Tropical Medicine and Hygiene 1989;40(5):507-13.
King 2002 {published data only}
  • King CH, Muchiri EM, Mungai P, Ouma JH, Kadzo H, Magak P, et al. Randomized comparison of low-dose versus standard-dose praziquantel therapy in treatment of urinary tract morbidity due to Schistosoma haematobium infection. American Journal of Tropical Medicine and Hygiene 2002;66(6):725-30.
McMahon 1979 {published data only}
  • McMahon JE, Kolstrup N. Praziquantel: a new schistosomicide against Schistosoma haematobium. British Medical Journal 1979;2(6202):1396-8.
McMahon 1983 {published data only}
  • McMahon JE. A comparative trial of praziquantel, metrifonate and niridazole against Schistosoma haematobium. Annals of Tropical Medicine and Parasitology 1983;77(2):139-42.
Olds 1999 {published data only}
  • Olds GR, King C, Hewlett J, Olveda R, Wu G, Ouma J, et al. Double-blind placebo-controlled study of concurrent administration of albendazole and praziquantel in schoolchildren with schistosomiasis and geohelminths. Journal of Infectious Diseases 1999;179(4):996-1003.
Omer 1981 {published data only}
Oyediran 1981 {published data only}
  • Oyediran AB, Kofie BA, Bammeke AO, Bamgboye EA. Clinical experience with praziquantel in the treatment of Nigerian patients infected with S. haematobium. Arzneimittel-Forschung 1981;31(3a):581-4.
Pugh 1983 {published data only}
  • Pugh RN, Teesdale CH. Long-term efficacy of single-dose oral treatment in schistosomiasis haematobium. Transaction of Royal Society of Tropical Medicine and Hygiene 1984;78(1):55-9.
  • Pugh RN, Teesdale CH. Single dose oral treatment in urinary schistosomiasis: a double blind trial. British Medical Journal 1983;286(6363):429-32.
Rey 1983 {published data only}
  • Rey JL, Sellin B, Gazere O, Ott D, Reges M, Garrouty P. Comparison study of praziquantel efficiency (30 mg/kg and 40 mg/kg) in a single dose and oltipraz (35 mg/kg) in two doses on schistosoma haematobium in Niger [Comparaison au Niger de l'efficacité sur schistosoma haematobium du praziquantel (30 mg/kg et 40 mg/kg) en une prise et de l'oltipraz (35mg/kg) en deux prises]. Médecine et Maladies Infectieuses 1983;13(6):328-31.
Rey 1984b {published data only}
  • Rey JL, Nouhou H, Sellin B. Comparison of 3 metrifonate dosages in mass chemotherapy of Schistosoma haematobium [Comparaison de trois posologies de metrifonate en chimiotherapie de mass contre Schistosoma haematobium]. Médecine Tropicale 1984;44(1):57-60.
Stephenson 1985 {published data only}
  • Stephenson LS, Latham MC, Kinoti SN, Oduori ML. Regression of splenomegaly and hepatomegaly in children treated for Schistosoma haematobium infection. American Journal Tropical Medicine and Hygiene 1985;34(1):119-23.
  • Stephenson LS, Latham MC, Kurz KM, Kinoti SN, Oduori ML, Crompton DW. Relationships of Schistosoma haematobium, hookworm and malarial infections and metrifonate treatment to growth of Kenyan school children. American Journal of Tropical Medicine and Hygiene 1985;34(6):1109-18.
  • Stephenson LS, Latham MC, Kurz KM, Kinoti SN, Oduori ML, Crompton DW. Relationships of Schistosoma hematobium, hookworm and malarial infections and metrifonate treatment to hemoglobin level in Kenyan school children. American Journal of Tropical Medicine and Hygiene 1985;34(3):519-28.
Stephenson 1989 {published data only}
  • Latham MC, Stephenson LS, Kurz KM, Kinoti SN. Metrifonate or praziquantel treatment improves physical fitness and appetite of Kenyan schoolboys with Schistosoma haematobium and hookworm infections. American Journal of Tropical Medicine and Hygiene 1990;43(2):170-9.
  • Stephenson LS, Kinoti SN, Latham MC, Kurz KM, Kyobe J. Single dose metrifonate or praziquantel treatment in Kenyan children. I. Effects on Schistosoma haematobium, hookworm, hemoglobin levels, splenomegaly and hepatomegaly. American Journal of Tropical Medicine and Hygiene 1989;41(4):436-44.
  • Stephenson LS, Latham MC, Kurz KM, Kinoti SN. Single dose metrifonate or praziquantel treatment in Kenyan children. II. Effects on growth in relation to Schistosoma haematobium and hookworm egg counts. American Journal of Tropical Medicine and Hygiene 1989;41(4):445-53.
Taylor 1988 {published data only}
  • Taylor P, Murare HM, Manomano K. Efficacy of low doses of praziquantel for Schistosoma mansoni and S. haematobium. Journal of Tropical Medicine and Hygiene 1988;91(1):13-7.
Wilkins 1987a {published data only}
  • Wilkins HA, Moore PJ. Comparative trials of regimes for the treatment of urinary schistosomiasis in The Gambia. Journal of Tropical Medicine and Hygiene 1987;90(2):83-92.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Aden-Abdi 1987 {published data only}
  • Aden-Abdi Y, Gustafsson LL, Elmi SA. A simplified dosage schedule of metrifonate in the treatment of Schistosoma haematobium infection in Somalia. European Journal of Clinical Pharmacology 1987;32(5):437-41.
Boulanger 2007 {published data only}
  • Boulanger D, Dieng Y, Cisse B, Remoue F, Capuano F, Dieme JL, et al. Antischistosomal efficacy of artesunate combination therapies administered as curative treatments for malaria attacks. Transaction of The Royal Society of Tropical Medicine and Hygiene 2007;101(2):113-6.
De Clercq 2002 {published data only}
  • De Clercq D, Vercruysse J, Kongs A, Verlé P, Dompnier JP, Faye PC. Efficacy of artesunate and praziquantel in Schistosoma haematobium infected schoolchildren. Acta Tropica 2002;82(1):61-6.
Druilhe 1981 {published data only}
  • Druilhe P, Bourdillon F, Froment A, Kyelem JM. Control of urinary schistosomiasis by 3 annual courses of metrifonate [Essai de controle de la bilharoziose urinarire par 3 cures annuelles de metrifonate]. Annales de la Societe Belge de Medecine Tropicale 1981;61(1):99-109.
Inyang-Etoh 2004 {published data only}
  • Inyang-Etoh PC, Ejezie GC, Useh MF, Inyang-Etoh EC. Efficacy of artesunate in the treatment of urinary schistosomiasis, in an endemic community in Nigeria. Annals of Tropical Medicine and Parasitology 2004;98(5):491-9.
Kardaman 1983 {published data only}
  • Kardaman MW, Amin MA, Fenwick A, Cheesmond AK, Dixon HG. A field trial using praziquantel (BiltricideR) to treat Schistosoma mansoni and Schistosoma haematobium infection in Gezira, Sudan. Annals of Tropical Medicine and Parasitology 1983;77(3):297-304.
N'Goran 2003a {published data only}
  • N'Goran EK, Gnaka HN, Tanner M, Utzinger J. Efficacy and side-effects of two praziquantel treatments against Schistosoma haematobium infection, among schoolchildren from Côte d'Ivoire. Annals of Tropical Medicine and Parasitology 2003;97(1):37-51.
N'Goran 2003b {published data only}
  • N'Goran EK, Utzinger J, Gnaka HN, Yapi A, N'Guessan NA, Kigbafori SD, et al. Randomized, double-blind, placebo-controlled trial of oral artemether for the prevention of patent Schistosoma haematobium infections. American Journal of Tropical Medicine and Hygiene 2003;68(1):24-32.
Rey 1984 {published data only}
  • Rey JL, Sellin E, Sellin B, Simonkovich E, Mouchet F. Efficacite comparee de l'oltipraz (1 dose, 30 mg/kg) et de l'association niridazole (25 mg/kg) - metrifonate (10 mg/kg) contre S haematobium [Comparative efficacy of oltipraz (1 dose, 30 mg/kg) and the combination of niridazole (25 mg/kg) and metrifonate (10 mg/kg) against S. haematobium]. Médecine Tropicale 1984;44(2):155-8.
Saif M 1981 {published data only}
  • Saif M, Abdel-Meguid M. Observations on tolerance and efficacy of praziquantel in Egyptian patients infected simultaneously with S. haematobium and S. mansoni. Arzneimittelforschung 1981;31(3a):604.
Schutte 1983 {published data only}
  • Schutte CH, Osman Y, Van Deventer JM, Mosese G. Effectiveness of praziquantel against the South African strains of Schistosoma haematobium and S. mansoni. South African Medical Journal (Suid-Afrikaanse Tydskrif Vir Geneeskunde) 1983; 64(1):7-10 1983;64(1):7-10.
Snyman 1997 {published data only}
  • Snyman JR, de Sommers K, Steinmann MA, Lizamore D. Effects of calcitriol on eosinophil activity and antibody responses in patients with schistosomiasis. European Journal of Clinical Pharmacology 1997;52(4):277-80.
Taylor 2001 {published data only}
  • Taylor M, Jinabhai CC, Couper I, Kleinschmidt I, Jogessar VB. The effect of different anthelmintic treatment regimens combined with iron supplementation on the nutritional status of schoolchildren in KwaZulu-Natal, South Africa: a randomized controlled trial. Transactions of the Royal Society of Tropical Medicine and Hygiene 2001;95(2):211-6.
Tchuem Tchuente 2004 {published data only}
  • Tchuenté LA, Shaw DJ, Polla L, Cioli D, Vercruysse J. Efficacy of praziquantel against Schistosoma haematobium infection in children. American Journal of Tropical Medicine and Hygiene 2004;71(6):778-82.
Utzinger 2001a {published data only}
Utzinger 2003 {published data only}
  • Utzinger J, Keiser J, Shuhua X, Tanner M, Singer BH. Combination chemotherapy of schistosomiasis in laboratory studies and clinical trials. Antimicrobial Agents and Chemotherapy 2003;47(5):1487-95.
Wilkins 1987b {published data only}
  • Wilkins HA, Moore PJ. Comparative trials of regimes for the treatment of urinary schistosomiasis in The Gambia. Journal of Tropical Medicine and Hygiene 1987;90(2):83-92.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Ansell 1997
  • Ansell J, Guyatt H, Hall A, Kihamia C, Kivugo J, Ntimbwa P, et al. The reliability of self-reported blood in urine and schistosomiasis as an indicator of Schistosoma haematobium infection in school children: a study in Muheza district, Tanzania. Tropical Medicine and International Health 1997;2(12):1180-9.
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References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Squires 1997
  • Squires N. Interventions for treating schistosomiasis haematobium. Cochrane Database of Systematic Reviews 1997, Issue 3. [DOI: 10.1002/14651858.CD000053]